Kyle
@rohdelab.bsky.social
Professor, Burnett School of Biomed Sci., College of Medicine, University of Central Florida.
Nerdy interests: TB, NTMs, Abx and AMR, gene regulation.
Less Nerdy interests: volleyball, cycling, reading.
Nerdy interests: TB, NTMs, Abx and AMR, gene regulation.
Less Nerdy interests: volleyball, cycling, reading.
Reposted by Kyle
Today @who.int released their 2025 #tuberculosis report, and figures remain unacceptable: 1.2 million children and young adolescents fell ill in 2024, and a staggering 43% were never diagnosed and thus missed lifesaving treatment. Act now to close the deadly gap!
msfaccess.org/msf-responds...
msfaccess.org/msf-responds...
November 12, 2025 at 3:22 PM
Today @who.int released their 2025 #tuberculosis report, and figures remain unacceptable: 1.2 million children and young adolescents fell ill in 2024, and a staggering 43% were never diagnosed and thus missed lifesaving treatment. Act now to close the deadly gap!
msfaccess.org/msf-responds...
msfaccess.org/msf-responds...
Reposted by Kyle
This paper does a great job with a "It's a Wonderful Life" scenario about NIH, supposing the consequences of the bottom 40% of the funding NIH grants never existed.
www.science.org/doi/10.1126/...
tl:dr The world would lose a lot, but directly and indirectly
www.science.org/doi/10.1126/...
tl:dr The world would lose a lot, but directly and indirectly
What if NIH had been 40% smaller?
Replaying history with less NIH funding shows widespread impacts on drug-linked research
www.science.org
September 26, 2025 at 11:01 AM
This paper does a great job with a "It's a Wonderful Life" scenario about NIH, supposing the consequences of the bottom 40% of the funding NIH grants never existed.
www.science.org/doi/10.1126/...
tl:dr The world would lose a lot, but directly and indirectly
www.science.org/doi/10.1126/...
tl:dr The world would lose a lot, but directly and indirectly
Reposted by Kyle
US lab data show sharp increase in superbug incidence
In 29 states, reporting of carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) clinical cultures rose by 69% from 2019 through 2023.
www.cidrap.umn.edu/a...
In 29 states, reporting of carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) clinical cultures rose by 69% from 2019 through 2023.
www.cidrap.umn.edu/a...
September 23, 2025 at 3:22 PM
US lab data show sharp increase in superbug incidence
In 29 states, reporting of carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) clinical cultures rose by 69% from 2019 through 2023.
www.cidrap.umn.edu/a...
In 29 states, reporting of carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) clinical cultures rose by 69% from 2019 through 2023.
www.cidrap.umn.edu/a...
Reposted by Kyle
Now online! Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Systematic antigen selection is an enduring challenge in tuberculosis (TB) vaccine development. An antigen screen ranks protective CD4 T cell antigens and yields a novel trivalent mRNA vaccine that protects against TB challenges in mice.
dlvr.it
September 15, 2025 at 6:52 PM
Now online! Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Reposted by Kyle
New research estimates that as many as 2.2 million more people could die of tuberculosis if U.S. cuts to foreign aid become permanent.
TB is the No. 1 killer among infectious diseases. A new study says its toll could mount
New research estimates that as many as 2.2 million more people could die of tuberculosis if U.S. cuts to foreign aid become permanent.
n.pr
September 13, 2025 at 11:19 AM
New research estimates that as many as 2.2 million more people could die of tuberculosis if U.S. cuts to foreign aid become permanent.
Reposted by Kyle
Wow!
Covid vaccine development and delivery cost $79.4 billion, but the health and economic benefits of vaccination were valued between $4.83 trillion–$37.8 trillion.
A return on investment of $59.8–$475 per dollar invested!!
This is why vaccine equity matters!
www.medrxiv.org/content/10.1...
Covid vaccine development and delivery cost $79.4 billion, but the health and economic benefits of vaccination were valued between $4.83 trillion–$37.8 trillion.
A return on investment of $59.8–$475 per dollar invested!!
This is why vaccine equity matters!
www.medrxiv.org/content/10.1...
The global return-on-investment of COVID-19 vaccines in the first year of the vaccination programme
COVID-19 vaccines played a critical role in reducing global health burden during the COVID-19 pandemic, but their rapid development required extraordinary effort. This study aims to evaluate their glo...
www.medrxiv.org
September 7, 2025 at 8:58 PM
Wow!
Covid vaccine development and delivery cost $79.4 billion, but the health and economic benefits of vaccination were valued between $4.83 trillion–$37.8 trillion.
A return on investment of $59.8–$475 per dollar invested!!
This is why vaccine equity matters!
www.medrxiv.org/content/10.1...
Covid vaccine development and delivery cost $79.4 billion, but the health and economic benefits of vaccination were valued between $4.83 trillion–$37.8 trillion.
A return on investment of $59.8–$475 per dollar invested!!
This is why vaccine equity matters!
www.medrxiv.org/content/10.1...
Reposted by Kyle
Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...
August 18, 2025 at 2:31 PM
Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...
Reposted by Kyle
Sterilizing activity of spectinamide MBX-4888A when replacing linezolid in the Nix-TB regimen in the relapsing BALB/c mouse model of tuberculosis https://www.biorxiv.org/content/10.1101/2025.08.04.668403v1
August 6, 2025 at 6:16 PM
Sterilizing activity of spectinamide MBX-4888A when replacing linezolid in the Nix-TB regimen in the relapsing BALB/c mouse model of tuberculosis https://www.biorxiv.org/content/10.1101/2025.08.04.668403v1
Reposted by Kyle
14 GOP senators are urging the Trump admin to release stalled NIH funds, warning that delays could shut down life-saving research, cost jobs, and erode public trust in science.
On the line? Real people, real cures, real consequences.
zurl.co/TlewL
On the line? Real people, real cures, real consequences.
zurl.co/TlewL
14 Republican senators urge White House to release delayed NIH funds
Sen. Katie Britt (R-Ala.) is leading the letter making the ask of OMB director Russ Vought.
zurl.co
July 28, 2025 at 10:21 PM
14 GOP senators are urging the Trump admin to release stalled NIH funds, warning that delays could shut down life-saving research, cost jobs, and erode public trust in science.
On the line? Real people, real cures, real consequences.
zurl.co/TlewL
On the line? Real people, real cures, real consequences.
zurl.co/TlewL
Reposted by Kyle
Group criticizes NIH over suspended funding for TB research
The Treatment Action Group says the 22 TB projects whose funding was suspended by NIH don't involve "gain-of-function" research.
www.cidrap.umn.edu/t...
The Treatment Action Group says the 22 TB projects whose funding was suspended by NIH don't involve "gain-of-function" research.
www.cidrap.umn.edu/t...
July 25, 2025 at 7:47 PM
Group criticizes NIH over suspended funding for TB research
The Treatment Action Group says the 22 TB projects whose funding was suspended by NIH don't involve "gain-of-function" research.
www.cidrap.umn.edu/t...
The Treatment Action Group says the 22 TB projects whose funding was suspended by NIH don't involve "gain-of-function" research.
www.cidrap.umn.edu/t...
Reposted by Kyle
We sure are getting back to those good old glory days … of needing tuberculosis clinics
DeKalb County, which has the highest rate of tuberculosis cases in Georgia, is opening a new clinic to help test for the bacterial infection and treat it. Here's why cases are so high.
DeKalb County has the highest rate of TB in the state. A new clinic aims to help.
DeKalb County, which has the highest rate of tuberculosis cases in Georgia, is opening a new clinic to help test for the bacterial infection and treat it. Here's why cases are so high.
bit.ly
July 19, 2025 at 1:01 AM
We sure are getting back to those good old glory days … of needing tuberculosis clinics
Reposted by Kyle
For the Mtb-focused colleagues, if you haven't seen this issue of ACS Infectious Diseases yet, you can find it here. Lots of good stuff in there.
pubs.acs.org/page/aidcbc/...
pubs.acs.org/page/aidcbc/...
Combating Tuberculosis: Obstacles, Innovations, and the Road Ahead
Tuberculosis (TB) remains one of the world’s leading infectious diseases. Every year on March 24th, World Tuberculosis Day is observed, which in 1882 is when Robert Koch announced the discovery of Mycobacterium tuberculosis (Mtb) as the causative agent of TB. This Special Issue features 30 original research articles, perspectives, and reviews from researchers representing 11 countries across all six major continents. ACS Infectious Diseases hopes this special issue encourages our readers to explore the wide range of research showcasing advances in drug discovery and a greater understanding of TB biology.
pubs.acs.org
July 15, 2025 at 2:08 PM
For the Mtb-focused colleagues, if you haven't seen this issue of ACS Infectious Diseases yet, you can find it here. Lots of good stuff in there.
pubs.acs.org/page/aidcbc/...
pubs.acs.org/page/aidcbc/...
Reposted by Kyle
Our work estimating the potential impacts of reductions in international donor funding for #TB is now out in @lancetgh.bsky.social:
bit.ly/3TDl28T
@raclark18.bsky.social @cfmcquaid.bsky.social @alexandra-richards.bsky.social @top-j.bsky.social @reinhouben.bsky.social @richardwhite321.bsky.social
bit.ly/3TDl28T
@raclark18.bsky.social @cfmcquaid.bsky.social @alexandra-richards.bsky.social @top-j.bsky.social @reinhouben.bsky.social @richardwhite321.bsky.social
July 14, 2025 at 8:46 AM
Our work estimating the potential impacts of reductions in international donor funding for #TB is now out in @lancetgh.bsky.social:
bit.ly/3TDl28T
@raclark18.bsky.social @cfmcquaid.bsky.social @alexandra-richards.bsky.social @top-j.bsky.social @reinhouben.bsky.social @richardwhite321.bsky.social
bit.ly/3TDl28T
@raclark18.bsky.social @cfmcquaid.bsky.social @alexandra-richards.bsky.social @top-j.bsky.social @reinhouben.bsky.social @richardwhite321.bsky.social
Reposted by Kyle
The White House Vision for Dismantling Science in One Simple Plot
joshuasweitz.substack.com/p/the-white-... by @joshuasweitz.bsky.social
joshuasweitz.substack.com/p/the-white-... by @joshuasweitz.bsky.social
The White House Vision for Dismantling Science in One Simple Plot
Proposed NIH, NSF, and NASA budgets would be catastrophic for innovation and discovery. But they aren’t reality yet. The time to speak up is now.
joshuasweitz.substack.com
July 11, 2025 at 3:09 PM
The White House Vision for Dismantling Science in One Simple Plot
joshuasweitz.substack.com/p/the-white-... by @joshuasweitz.bsky.social
joshuasweitz.substack.com/p/the-white-... by @joshuasweitz.bsky.social
Reposted by Kyle
In 2 trials, less toxic TB antibiotics show promise
The results of two phase 2b trials suggest sutezolid and delpazolid could provide safer alternatives to linezolid in shorter drug regimens for drug-resistant TB.
www.cidrap.umn.edu/t...
The results of two phase 2b trials suggest sutezolid and delpazolid could provide safer alternatives to linezolid in shorter drug regimens for drug-resistant TB.
www.cidrap.umn.edu/t...
July 10, 2025 at 7:45 PM
In 2 trials, less toxic TB antibiotics show promise
The results of two phase 2b trials suggest sutezolid and delpazolid could provide safer alternatives to linezolid in shorter drug regimens for drug-resistant TB.
www.cidrap.umn.edu/t...
The results of two phase 2b trials suggest sutezolid and delpazolid could provide safer alternatives to linezolid in shorter drug regimens for drug-resistant TB.
www.cidrap.umn.edu/t...
Reposted by Kyle
BREAKING: Scientists are staging a “science fair” in the lobby of a Congressional building to tell elected officials about the critical knowledge the US will lose because their research grants have been canceled.
July 8, 2025 at 3:31 PM
BREAKING: Scientists are staging a “science fair” in the lobby of a Congressional building to tell elected officials about the critical knowledge the US will lose because their research grants have been canceled.
Reposted by Kyle
Letter urges HHS to convene meeting of advisory group on antimicrobial resistance
The letter from the American Society for Microbiology calls for the President's Advisory Council on Combating Antibiotic Resistant Bacteria to meet 'as soon as possible.'
www.cidrap.umn.edu/a...
The letter from the American Society for Microbiology calls for the President's Advisory Council on Combating Antibiotic Resistant Bacteria to meet 'as soon as possible.'
www.cidrap.umn.edu/a...
Letter urges HHS to convene meeting of advisory group on antimicrobial resistance
The letter from the American Society for Microbiology and 40 other groups calls for the President's Advisory Council on Combating Antibiotic Resistant Bacteria to meet 'as soon as possible.'
www.cidrap.umn.edu
June 23, 2025 at 8:49 PM
Letter urges HHS to convene meeting of advisory group on antimicrobial resistance
The letter from the American Society for Microbiology calls for the President's Advisory Council on Combating Antibiotic Resistant Bacteria to meet 'as soon as possible.'
www.cidrap.umn.edu/a...
The letter from the American Society for Microbiology calls for the President's Advisory Council on Combating Antibiotic Resistant Bacteria to meet 'as soon as possible.'
www.cidrap.umn.edu/a...
Reposted by Kyle
“universities contributed patents underpinning 50% of FDA-approved drugs…
NIH-funded basic science has contributed to the development of more than 90% of new medicines, vaccines, and devices…
75% of scientists in America were considering leaving the country.”
www.statnews.com/2025/06/06/u...
NIH-funded basic science has contributed to the development of more than 90% of new medicines, vaccines, and devices…
75% of scientists in America were considering leaving the country.”
www.statnews.com/2025/06/06/u...
We set out to quantify U.S. academic contributions to medicines. The results stunned even us
From 2020 to 2024, universities contributed patents underpinning 50% of FDA-approved drugs. 87% of those academic breakthroughs came from American institutions.
www.statnews.com
June 7, 2025 at 5:21 PM
“universities contributed patents underpinning 50% of FDA-approved drugs…
NIH-funded basic science has contributed to the development of more than 90% of new medicines, vaccines, and devices…
75% of scientists in America were considering leaving the country.”
www.statnews.com/2025/06/06/u...
NIH-funded basic science has contributed to the development of more than 90% of new medicines, vaccines, and devices…
75% of scientists in America were considering leaving the country.”
www.statnews.com/2025/06/06/u...
Reposted by Kyle
“M. tuberculosis has evolved into an astonishingly adept human pathogen. And one of its greatest skills is its ability to fly through the air”
@carlzimmer.com on why TB has killed millions over the ages
www.newscientist.com/article/2481...
@carlzimmer.com on why TB has killed millions over the ages
www.newscientist.com/article/2481...
TB's extraordinary evolution reveals why the ancient disease lives on
Once thought to have originated in cows and spread through dust, the surprising evolutionary story of tuberculosis reveals why it's so hard to stamp out this ancient disease, writes Carl Zimmer
www.newscientist.com
June 4, 2025 at 8:57 PM
“M. tuberculosis has evolved into an astonishingly adept human pathogen. And one of its greatest skills is its ability to fly through the air”
@carlzimmer.com on why TB has killed millions over the ages
www.newscientist.com/article/2481...
@carlzimmer.com on why TB has killed millions over the ages
www.newscientist.com/article/2481...
Reposted by Kyle
Please consider passing around this very informative interview to everyone you know (especially non-scientists). I believe it does an excellent job explaining why taxpayers benefit from the federal government’s support of scientific research.
www.pbs.org/video/breakt...
www.pbs.org/video/breakt...
Amanpour and Company | Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Season 2025
David Liu joins the show.
www.pbs.org
May 25, 2025 at 1:48 PM
Please consider passing around this very informative interview to everyone you know (especially non-scientists). I believe it does an excellent job explaining why taxpayers benefit from the federal government’s support of scientific research.
www.pbs.org/video/breakt...
www.pbs.org/video/breakt...
Reposted by Kyle
The Blue Journal thanks Rachel Thomson, MBBS, Grad Dip (Clin Epi), PhD, FRACP, ATSF, for her contribution to the May issue
@atscommunity.bsky.social
Infection by Clonally Related Mycobacterium abscessus Isolates: The Role of Drinking Water
www.atsjournals.org/doi/10.1164/...
@atscommunity.bsky.social
Infection by Clonally Related Mycobacterium abscessus Isolates: The Role of Drinking Water
www.atsjournals.org/doi/10.1164/...
May 5, 2025 at 9:09 PM
The Blue Journal thanks Rachel Thomson, MBBS, Grad Dip (Clin Epi), PhD, FRACP, ATSF, for her contribution to the May issue
@atscommunity.bsky.social
Infection by Clonally Related Mycobacterium abscessus Isolates: The Role of Drinking Water
www.atsjournals.org/doi/10.1164/...
@atscommunity.bsky.social
Infection by Clonally Related Mycobacterium abscessus Isolates: The Role of Drinking Water
www.atsjournals.org/doi/10.1164/...
Reposted by Kyle
Deaths from heart disease down 75%, that’s NIH.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
April 28, 2025 at 5:20 PM
Deaths from heart disease down 75%, that’s NIH.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Reposted by Kyle
#Tuberculosis is the world's deadliest infectious disease, but it has a cure! However, because of cost, treatment length, and availability of testing, not everyone can complete treatment. www.who.int/news-roo...
April 29, 2025 at 12:07 AM
#Tuberculosis is the world's deadliest infectious disease, but it has a cure! However, because of cost, treatment length, and availability of testing, not everyone can complete treatment. www.who.int/news-roo...