Rodrigo Romero Rangel
@rodrigoromero.bsky.social
Postdoc in Sawyers lab @MSKCC | PhD Jacks lab @MIT Biology | GEMMs 🐭, organoids, lineage plasticity, & wannabe cancer immunologist | 🐶x2 dad | 🇨🇴🇻🇪
Reposted by Rodrigo Romero Rangel
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature
Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...
www.nature.com
December 18, 2024 at 4:54 PM
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Reposted by Rodrigo Romero Rangel
Really interesting paper on how aging limits lung cancer progression by the Tammela lab www.nature.com/articles/s41...
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature
Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.
www.nature.com
December 6, 2024 at 1:28 PM
Really interesting paper on how aging limits lung cancer progression by the Tammela lab www.nature.com/articles/s41...
Reposted by Rodrigo Romero Rangel
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...
November 27, 2024 at 10:17 PM
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...
Reposted by Rodrigo Romero Rangel
I’m excited to share new work out of the lab in Nature Metabolism today on the impact of tumor-relevant glucose concentrations on the response to pyrimidine synthesis inhibitors. t.co/9hOGW4x97T. PDF: rdcu.be/d1vkV
https://www.nature.com/articles/s42255-024-01166-w
t.co
November 26, 2024 at 7:58 PM
I’m excited to share new work out of the lab in Nature Metabolism today on the impact of tumor-relevant glucose concentrations on the response to pyrimidine synthesis inhibitors. t.co/9hOGW4x97T. PDF: rdcu.be/d1vkV
Reposted by Rodrigo Romero Rangel
Very excited to share our latest publication on the role of NOTCH1 in sexual dimorphism in liver cancer and published in
Cancer Discovery! Super proud of Katie Lindblad for leading this study as part of her outstanding PhD work.
Cancer Discovery! Super proud of Katie Lindblad for leading this study as part of her outstanding PhD work.
NOTCH1 Drives Sexually Dimorphic Immune Responses in Hepatocellular Carcinoma - by Katherine Lindblad1, @amaialujambio.bsky.social and colleagues doi.org/10.1158/2159...
November 21, 2024 at 5:42 PM
Very excited to share our latest publication on the role of NOTCH1 in sexual dimorphism in liver cancer and published in
Cancer Discovery! Super proud of Katie Lindblad for leading this study as part of her outstanding PhD work.
Cancer Discovery! Super proud of Katie Lindblad for leading this study as part of her outstanding PhD work.
Reposted by Rodrigo Romero Rangel
In collaboration with Reuben Saunders, @jswlab.bsky.social, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
www.biorxiv.org/content/10.1...
Check it out!
www.biorxiv.org/content/10.1...
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...
www.biorxiv.org
November 21, 2024 at 6:24 PM
In collaboration with Reuben Saunders, @jswlab.bsky.social, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
www.biorxiv.org/content/10.1...
Check it out!
www.biorxiv.org/content/10.1...
Reposted by Rodrigo Romero Rangel
The Vaishnavi Lab is hiring a new RAII! Interested in learning more about mouse models of lung cancer? jobs.mdanderson.org/search/jobde... Please RT!
#lcsm #AcademicChatter
#lcsm #AcademicChatter
Research Assistant II - Genetics at MD Anderson
MD Anderson is Hiring! Search available jobs or submit your resume now by visiting this link. Please share with anyone you feel would be a great fit.
jobs.mdanderson.org
November 21, 2024 at 8:00 PM
The Vaishnavi Lab is hiring a new RAII! Interested in learning more about mouse models of lung cancer? jobs.mdanderson.org/search/jobde... Please RT!
#lcsm #AcademicChatter
#lcsm #AcademicChatter
Reposted by Rodrigo Romero Rangel
new out in Nature www.nature.com/articles/s41...
Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma - Nature
The prodrug gliocidin effectively kills glioblastoma cells by targeting de novo purine synthesis, improving survival in mouse models.
www.nature.com
November 20, 2024 at 5:06 PM
new out in Nature www.nature.com/articles/s41...
Reposted by Rodrigo Romero Rangel
Dear new #science #STEM community-
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:
November 16, 2024 at 1:01 PM
Dear new #science #STEM community-
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because: