Robel Alemu
@robel-alemu.bsky.social
Postdoctoral Scholar @UCLA & Affiliate Fellow @broadinstitute of @MIT and @Harvard. Alumni @TuftsUniversity. GWAS of complex traits. Unraveling GxE effects.
Pinned
Robel Alemu
@robel-alemu.bsky.social
· Sep 18
Excited to share our preprint on PGI portability across ancestries—now on bioRxiv. With co-authors @aysuo.bsky.social, @paturley.bsky.social, @alextisyoung.bsky.social, and @Dan_J_Benjamin. Preprint: doi.org/10.1101/2025... Thread below for details.
Excited to share our preprint on PGI portability across ancestries—now on bioRxiv. With co-authors @aysuo.bsky.social, @paturley.bsky.social, @alextisyoung.bsky.social, and @Dan_J_Benjamin. Preprint: doi.org/10.1101/2025... Thread below for details.
September 18, 2025 at 3:07 PM
Excited to share our preprint on PGI portability across ancestries—now on bioRxiv. With co-authors @aysuo.bsky.social, @paturley.bsky.social, @alextisyoung.bsky.social, and @Dan_J_Benjamin. Preprint: doi.org/10.1101/2025... Thread below for details.
Reposted by Robel Alemu
Brilliant paper by Visscher et al.
Populations differ in traits/disease burden. Are these differences due to genetics?
Comparing single variants or polygenic scores between populations is biased due to environmental confounders correlated with the variants.
1/3
www.medrxiv.org/content/10.1...
Populations differ in traits/disease burden. Are these differences due to genetics?
Comparing single variants or polygenic scores between populations is biased due to environmental confounders correlated with the variants.
1/3
www.medrxiv.org/content/10.1...
Direct effect of genetic ancestry on complex traits in a Mexican population
Human populations differ in disease prevalences and in average values of phenotypes, but the extent to which differences are caused by genetic or environmental factors is unknown for most complex trai...
www.medrxiv.org
September 11, 2025 at 5:57 AM
Brilliant paper by Visscher et al.
Populations differ in traits/disease burden. Are these differences due to genetics?
Comparing single variants or polygenic scores between populations is biased due to environmental confounders correlated with the variants.
1/3
www.medrxiv.org/content/10.1...
Populations differ in traits/disease burden. Are these differences due to genetics?
Comparing single variants or polygenic scores between populations is biased due to environmental confounders correlated with the variants.
1/3
www.medrxiv.org/content/10.1...
Reposted by Robel Alemu
ICYMI: New online! Harnessing functional annotation to improve the accuracy and transferability of polygenic scores
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores
Nature Reviews Genetics, Published online: 05 September 2025; doi:10.1038/s41576-025-00893-4The accuracy of polygenic scores (PGS) remains limited and poorly transferable across ancestries. In this Comment, Zeng and Visscher discuss how integrating functional annotations with whole-genome sequencing data can improve PGS by prioritizing likely causal variants shared across populations and by assigning greater weight to variants in biologically relevant regions.
www.nature.com
September 12, 2025 at 11:22 AM
ICYMI: New online! Harnessing functional annotation to improve the accuracy and transferability of polygenic scores
Reposted by Robel Alemu
Eight academic health policy researchers present their global health projects—from Ethiopia to China to Argentina and beyond—during our annual #RosenkranzGlobal health symposium. See the slideshow.
healthpolicy.fsi.stanford.edu/content/2025...
healthpolicy.fsi.stanford.edu/content/2025...
June 9, 2025 at 8:34 PM
Eight academic health policy researchers present their global health projects—from Ethiopia to China to Argentina and beyond—during our annual #RosenkranzGlobal health symposium. See the slideshow.
healthpolicy.fsi.stanford.edu/content/2025...
healthpolicy.fsi.stanford.edu/content/2025...
Reposted by Robel Alemu
Robel Alemu, a postdoc research scientist at UCLA and
the @broadinstitute.org, shows abrupt and prolonged loss of iodized salt in Ethiopian children harms later-life academic achievement, earnings & survival. @robel-alemu.bsky.social Learn More: bit.ly/3H0V5go
the @broadinstitute.org, shows abrupt and prolonged loss of iodized salt in Ethiopian children harms later-life academic achievement, earnings & survival. @robel-alemu.bsky.social Learn More: bit.ly/3H0V5go
May 21, 2025 at 10:35 PM
Robel Alemu, a postdoc research scientist at UCLA and
the @broadinstitute.org, shows abrupt and prolonged loss of iodized salt in Ethiopian children harms later-life academic achievement, earnings & survival. @robel-alemu.bsky.social Learn More: bit.ly/3H0V5go
the @broadinstitute.org, shows abrupt and prolonged loss of iodized salt in Ethiopian children harms later-life academic achievement, earnings & survival. @robel-alemu.bsky.social Learn More: bit.ly/3H0V5go
Reposted by Robel Alemu
PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social
An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1
May 20, 2025 at 10:18 AM
PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social
In our lastest review article, we explore the evolving landscape of multi-omics research in NCDs.
A huge thank you to collaborators Nigussie T. Sharew, Yodit Y. Arsano, Muktar Ahmed, Fasil Tekola-Ayele, Tesfaye B. Mersha, and Azmeraw T. Amare
📖 Read the full article here: doi.org/10.1186/s402...
A huge thank you to collaborators Nigussie T. Sharew, Yodit Y. Arsano, Muktar Ahmed, Fasil Tekola-Ayele, Tesfaye B. Mersha, and Azmeraw T. Amare
📖 Read the full article here: doi.org/10.1186/s402...
Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues - Human Genomics
Non-communicable diseases (NCDs) such as cardiovascular diseases, chronic respiratory diseases, cancers, diabetes, and mental health disorders pose a significant global health challenge, accounting fo...
doi.org
February 4, 2025 at 4:30 PM
In our lastest review article, we explore the evolving landscape of multi-omics research in NCDs.
A huge thank you to collaborators Nigussie T. Sharew, Yodit Y. Arsano, Muktar Ahmed, Fasil Tekola-Ayele, Tesfaye B. Mersha, and Azmeraw T. Amare
📖 Read the full article here: doi.org/10.1186/s402...
A huge thank you to collaborators Nigussie T. Sharew, Yodit Y. Arsano, Muktar Ahmed, Fasil Tekola-Ayele, Tesfaye B. Mersha, and Azmeraw T. Amare
📖 Read the full article here: doi.org/10.1186/s402...