Gregory Riely
@rielymd.bsky.social
Medical Oncologist in NYC. Ning Zhao and Ge Li Endowed Chair. Lung and thymic cancer. COI: https://coi.asco.org/share/EXW-L4KS/Gregory%20Riely
Reposted by Gregory Riely
More mechanisms of resistance to anti-HER2 ADCs, this time with a focus on loss of target interaction!
In this manuscript, online today in Cancer Discovery, we investigate target-mediated resistance to ADCs, and propose ways to overcome it.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding
Abstract. T-DXd is clinically beneficial in HER2 positive and HER2 low metastatic breast cancer. However, therapeutic resistance emerges over time in most patients, with poorly defined resistance mech...
aacrjournals.org
November 10, 2025 at 7:10 PM
More mechanisms of resistance to anti-HER2 ADCs, this time with a focus on loss of target interaction!
Reposted by Gregory Riely
ADC resistance is likely heterogeneous, and the phenomena above may explain only a portion of cases. But these early clues can inform prospective trail efforts, as well as ADC sequencing strategies. There is much more to come!
November 10, 2025 at 4:55 PM
ADC resistance is likely heterogeneous, and the phenomena above may explain only a portion of cases. But these early clues can inform prospective trail efforts, as well as ADC sequencing strategies. There is much more to come!
Reposted by Gregory Riely
In this manuscript, online today in Cancer Discovery, we investigate target-mediated resistance to ADCs, and propose ways to overcome it.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding
Abstract. T-DXd is clinically beneficial in HER2 positive and HER2 low metastatic breast cancer. However, therapeutic resistance emerges over time in most patients, with poorly defined resistance mech...
aacrjournals.org
November 10, 2025 at 4:55 PM
In this manuscript, online today in Cancer Discovery, we investigate target-mediated resistance to ADCs, and propose ways to overcome it.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Reposted by Gregory Riely
Now online in Cancer Discovery @aacrjournals.bsky.social: Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding - by Wanyi Chen, @joshdragomd.bsky.social, @saratchandarlapaty.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social
November 10, 2025 at 6:15 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding - by Wanyi Chen, @joshdragomd.bsky.social, @saratchandarlapaty.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social
Reposted by Gregory Riely
A little more about trustworthy data visualization and the work of the philosopher Katherine Hawley.
kieranhealy.org/blog/archive...
kieranhealy.org/blog/archive...
Trustworthy Data Visualization
This past September I gave the closing keynote at posit::conf; it’s now on YouTube to watch. Keen-eyed observers will note from the title that it’s about trustworthy data visualization. But it’s also ...
kieranhealy.org
November 10, 2025 at 2:01 PM
A little more about trustworthy data visualization and the work of the philosopher Katherine Hawley.
kieranhealy.org/blog/archive...
kieranhealy.org/blog/archive...
Reposted by Gregory Riely
Interesting article out this week from Dr. Bishal Gyawali, arguing that we should use more superiority designs for treatment de-escalation studies in cancer.
"The burden of proof in medicine lies on more treatment."
academic.oup.com/jnci/advance...
"The burden of proof in medicine lies on more treatment."
academic.oup.com/jnci/advance...
November 7, 2025 at 10:31 PM
Interesting article out this week from Dr. Bishal Gyawali, arguing that we should use more superiority designs for treatment de-escalation studies in cancer.
"The burden of proof in medicine lies on more treatment."
academic.oup.com/jnci/advance...
"The burden of proof in medicine lies on more treatment."
academic.oup.com/jnci/advance...
This Congress will be in session tomorrow. Join us live or online! Great speakers with a multidisciplinary agenda. web.cvent.com/event/35cf07...
November 7, 2025 at 12:35 AM
This Congress will be in session tomorrow. Join us live or online! Great speakers with a multidisciplinary agenda. web.cvent.com/event/35cf07...
Reposted by Gregory Riely
I cancelled a full day of clinic 4 months ago for my study section meeting that was supposed to happen this week. Clearing our schedules to reschedule these cancelled grant review panels is not so easy…
November 3, 2025 at 3:47 PM
I cancelled a full day of clinic 4 months ago for my study section meeting that was supposed to happen this week. Clearing our schedules to reschedule these cancelled grant review panels is not so easy…
Reposted by Gregory Riely
Well reported story on the PBS News Hour about science cuts and the ongoing and potential brain drain.
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
Top researchers consider leaving U.S. amid funding cuts: 'The science world is ending'
YouTube video by PBS NewsHour
www.youtube.com
October 30, 2025 at 11:36 AM
Well reported story on the PBS News Hour about science cuts and the ongoing and potential brain drain.
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
Reposted by Gregory Riely
Clinic
Me: Ok, middle school already!
Kiddo, 12: Yep.
Me: You must be in 6 or 7th gra...Oh no.
12: SIX SEVEN SIX SEVEN SIX SEVEN-HahahahHA!
Me: The weird thing is, I know what that is, but I still don't understand it
12: Exactly! It's not for grownups
Me: Oh, well I'm fine with THAT.
#Pediatrics.
Me: Ok, middle school already!
Kiddo, 12: Yep.
Me: You must be in 6 or 7th gra...Oh no.
12: SIX SEVEN SIX SEVEN SIX SEVEN-HahahahHA!
Me: The weird thing is, I know what that is, but I still don't understand it
12: Exactly! It's not for grownups
Me: Oh, well I'm fine with THAT.
#Pediatrics.
October 30, 2025 at 11:55 AM
Clinic
Me: Ok, middle school already!
Kiddo, 12: Yep.
Me: You must be in 6 or 7th gra...Oh no.
12: SIX SEVEN SIX SEVEN SIX SEVEN-HahahahHA!
Me: The weird thing is, I know what that is, but I still don't understand it
12: Exactly! It's not for grownups
Me: Oh, well I'm fine with THAT.
#Pediatrics.
Me: Ok, middle school already!
Kiddo, 12: Yep.
Me: You must be in 6 or 7th gra...Oh no.
12: SIX SEVEN SIX SEVEN SIX SEVEN-HahahahHA!
Me: The weird thing is, I know what that is, but I still don't understand it
12: Exactly! It's not for grownups
Me: Oh, well I'm fine with THAT.
#Pediatrics.
Reposted by Gregory Riely
I have a number of colleagues who think that LLMs will be very useful as individualized tutors.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
October 30, 2025 at 10:37 AM
I have a number of colleagues who think that LLMs will be very useful as individualized tutors.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
Reposted by Gregory Riely
My quote of the day
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
October 30, 2025 at 11:10 AM
My quote of the day
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
Reposted by Gregory Riely
October 30, 2025 at 11:33 AM
Reposted by Gregory Riely
Seasonal diagnosis dept.
Potential presentation of #Halloween sugar rush.
Potential presentation of #Halloween sugar rush.
October 30, 2025 at 11:36 AM
Seasonal diagnosis dept.
Potential presentation of #Halloween sugar rush.
Potential presentation of #Halloween sugar rush.
Reposted by Gregory Riely
Medicaid cuts. Shutdowns...
US #healthcare has its work cut out for it—to cut costs. However, as we care for our patients, we need not be pennywise and poundfoolish. #medsky #graphicmedicine
US #healthcare has its work cut out for it—to cut costs. However, as we care for our patients, we need not be pennywise and poundfoolish. #medsky #graphicmedicine
October 30, 2025 at 11:39 AM
Medicaid cuts. Shutdowns...
US #healthcare has its work cut out for it—to cut costs. However, as we care for our patients, we need not be pennywise and poundfoolish. #medsky #graphicmedicine
US #healthcare has its work cut out for it—to cut costs. However, as we care for our patients, we need not be pennywise and poundfoolish. #medsky #graphicmedicine
Reposted by Gregory Riely
The worst thing about all the automated accounts flooding social media is that there is no point in trolling them.
October 30, 2025 at 9:54 AM
The worst thing about all the automated accounts flooding social media is that there is no point in trolling them.
Reposted by Gregory Riely
Excited to announce a new publication from our @mskcancercenter.bsky.social Histiocytosis group identifying a predictor for impaired response to MEK inhibition in histiocytosis patients and potential for ERK inhibition. Out today in @Cancer_Cell.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition
Histiocytic neoplasms are clonal disorders of the monocyte/macrophage lineage defined by mutations activating mitogen-activated protein kinase (MAPK) …
www.sciencedirect.com
October 23, 2025 at 3:26 PM
Excited to announce a new publication from our @mskcancercenter.bsky.social Histiocytosis group identifying a predictor for impaired response to MEK inhibition in histiocytosis patients and potential for ERK inhibition. Out today in @Cancer_Cell.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Gregory Riely
Here, Dr. Pedram Razavi explains MSK's efforts to prevent drug resistance from developing in #breastcancer patients. A new study seeks to anticipate the malignant cells' next move, like playing poker with cancer and being able to see most of its cards.
Learn more: bit.ly/47cxyDZ
Learn more: bit.ly/47cxyDZ
October 28, 2025 at 4:32 PM
Here, Dr. Pedram Razavi explains MSK's efforts to prevent drug resistance from developing in #breastcancer patients. A new study seeks to anticipate the malignant cells' next move, like playing poker with cancer and being able to see most of its cards.
Learn more: bit.ly/47cxyDZ
Learn more: bit.ly/47cxyDZ
Important translational and clinical work here using CD40 agonistic antibody in metastatic cancer @anatosaurus.bsky.social Cancer Cell www.cell.com/cancer-cell/... @mskcancercenter.bsky.social @mskdeptofmed.bsky.social
Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer
Osorio et al. report a first-in-human study of intratumoral 2141-V11, an Fc-engineered
CD40 agonistic antibody, showing it is safe and induces systemic and durable antitumor
immunity in patients with ...
www.cell.com
October 29, 2025 at 3:36 PM
Important translational and clinical work here using CD40 agonistic antibody in metastatic cancer @anatosaurus.bsky.social Cancer Cell www.cell.com/cancer-cell/... @mskcancercenter.bsky.social @mskdeptofmed.bsky.social
"...we have established a position as the world’s leader in biotechnology, but we’re quickly relinquishing that, with reduced government funding in research, threats of tariffs on pharmaceutical products, drug pricing policies that are pushing investors away, and a loss of talent..." @statnews.com
U.S. biomedical innovation must not go the way of semiconductors and shipbuilding
The U.S. has ceded its leadership in critical industries before. It must not do so with China and biotech now, writes the president and CEO of Biocom California.
www.statnews.com
October 29, 2025 at 3:33 PM
"...we have established a position as the world’s leader in biotechnology, but we’re quickly relinquishing that, with reduced government funding in research, threats of tariffs on pharmaceutical products, drug pricing policies that are pushing investors away, and a loss of talent..." @statnews.com
Scientists had to change more than 700 grant titles to receive NIH funding. Health disparities researchers fear what’s next www.statnews.com/2025/10/29/n... via @statnews.com
Scientists had to change more than 700 grant titles to receive NIH funding. Health disparities researchers fear what’s next
The titles of more than 700 multi-year NIH grants have been changed this year, according to an analysis by Jeremy Berg, a former agency official
www.statnews.com
October 29, 2025 at 3:29 PM
Scientists had to change more than 700 grant titles to receive NIH funding. Health disparities researchers fear what’s next www.statnews.com/2025/10/29/n... via @statnews.com
Reposted by Gregory Riely
This incident is spreading through Chicago running circles. A 67 year old man, driving back from a long run with his friends, is pulled from the car and thrown to the ground by ICE (or BP?) agents because he did... something.
www.youtube.com/watch?v=OWAw...
www.youtube.com/watch?v=OWAw...
67-year old American citizen left with broken ribs by ICE #breakingnews #iceraids #savedemocracy
YouTube video by Nick Valencia News
www.youtube.com
October 28, 2025 at 4:59 PM
This incident is spreading through Chicago running circles. A 67 year old man, driving back from a long run with his friends, is pulled from the car and thrown to the ground by ICE (or BP?) agents because he did... something.
www.youtube.com/watch?v=OWAw...
www.youtube.com/watch?v=OWAw...