Richard Mitchell
@richardmitchell210.bsky.social
Reposted by Richard Mitchell
Is disruption in science decreasing? Maybe not...
"Due to a factual plotting mistake, database entries with zero references were omitted in the CD index distributions, hiding a large number of outliers with a maximum CD index of one, while keeping them in the analysis"
the classic Seaborn bug 🫣
"Due to a factual plotting mistake, database entries with zero references were omitted in the CD index distributions, hiding a large number of outliers with a maximum CD index of one, while keeping them in the analysis"
the classic Seaborn bug 🫣
Dataset Artefacts are the Hidden Drivers of the Declining Disruptiveness in Science
Park et al. [1] reported a decline in the disruptiveness of scientific and technological knowledge over time. Their main finding is based on the computation of CD indices, a measure of disruption in c...
arxiv.org
July 17, 2025 at 12:21 PM
Is disruption in science decreasing? Maybe not...
"Due to a factual plotting mistake, database entries with zero references were omitted in the CD index distributions, hiding a large number of outliers with a maximum CD index of one, while keeping them in the analysis"
the classic Seaborn bug 🫣
"Due to a factual plotting mistake, database entries with zero references were omitted in the CD index distributions, hiding a large number of outliers with a maximum CD index of one, while keeping them in the analysis"
the classic Seaborn bug 🫣
Reposted by Richard Mitchell
Nature research paper: RNA codon expansion via programmable pseudouridine editing and decoding
https://go.nature.com/3G8f3G4
https://go.nature.com/3G8f3G4
RNA codon expansion via programmable pseudouridine editing and decoding - Nature
An RNA codon-expansion strategy enables incorporation of non-canonical amino acids into proteins of interest orthogonally to existing methods by inserting pseudouridine codons into specific mRNA transcripts and using an engineered decoder tRNA.
go.nature.com
June 28, 2025 at 11:13 AM
Nature research paper: RNA codon expansion via programmable pseudouridine editing and decoding
https://go.nature.com/3G8f3G4
https://go.nature.com/3G8f3G4
Reposted by Richard Mitchell
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by Richard Mitchell
Congrats to @richardmitchell210.bsky.social for an excellent study leveraging metabolic analysis! This paper shows how photodynamic therapy photosensitizers and photoactivated chemotherapeutics exhibit distinct bioenergetic profiles - now in Chemical Science (a 🧵) pubs.rsc.org/en/content/a...
Photodynamic therapy photosensitizers and photoactivated chemotherapeutics exhibit distinct bioenergetic profiles to impact ATP metabolism
Energy is essential for all life, and mammalian cells generate and store energy in the form of ATP by mitochondrial (oxidative phosphorylation) and non-mitochondrial (glycolysis) metabolism. These pro...
pubs.rsc.org
December 2, 2024 at 5:47 PM
Congrats to @richardmitchell210.bsky.social for an excellent study leveraging metabolic analysis! This paper shows how photodynamic therapy photosensitizers and photoactivated chemotherapeutics exhibit distinct bioenergetic profiles - now in Chemical Science (a 🧵) pubs.rsc.org/en/content/a...