Richard Kay
@richard-kay.bsky.social
Passionate about using mass spectrometry for studying disease. Clinical mass spectrometry (bioactive peptides and proteins) in the day, average triathlete in my spare time!
Where do injected peptide weight loss drugs end up in the body? What about known and currently uncharacterised peptides produced in the gut - where do they go? Want to help myself and Andreas Dannhorn from AstraZeneca try and find out how to do this?
September 26, 2025 at 11:38 AM
Where do injected peptide weight loss drugs end up in the body? What about known and currently uncharacterised peptides produced in the gut - where do they go? Want to help myself and Andreas Dannhorn from AstraZeneca try and find out how to do this?
Orbital Astrals and ZenoToFs are cool and all... But do you have Mass Specs??
Have a good weekend everyone!
#teammassspec
Have a good weekend everyone!
#teammassspec
August 15, 2025 at 4:20 PM
Orbital Astrals and ZenoToFs are cool and all... But do you have Mass Specs??
Have a good weekend everyone!
#teammassspec
Have a good weekend everyone!
#teammassspec
I have a clearly glycosylated peptide, which I think is an elusive peptide I am after, but it gives almost no peptide fragments. I asked ChatGPT for some help interpreting glycopeptide MS/MS spectra, it generated this abomination.. I think our jobs are secure for a little longer yet...
August 13, 2025 at 8:20 AM
I have a clearly glycosylated peptide, which I think is an elusive peptide I am after, but it gives almost no peptide fragments. I asked ChatGPT for some help interpreting glycopeptide MS/MS spectra, it generated this abomination.. I think our jobs are secure for a little longer yet...
The last ticket machine at Ely station printing the orange tickets has betrayed me.
Printing out the stupid slippery QR tickets that are 2.5 times the size of the old ones... Grrr..
Printing out the stupid slippery QR tickets that are 2.5 times the size of the old ones... Grrr..
August 7, 2025 at 6:48 AM
The last ticket machine at Ely station printing the orange tickets has betrayed me.
Printing out the stupid slippery QR tickets that are 2.5 times the size of the old ones... Grrr..
Printing out the stupid slippery QR tickets that are 2.5 times the size of the old ones... Grrr..
An article on the Cambridge University website about a challenging peptide I have worked on for over a decade.
@cabannon.bsky.social and the rest of the project team showed it was raised in plasma from patients with bile acid diarrhea and inflammatory gut diseases.
www.cam.ac.uk/research/new...
@cabannon.bsky.social and the rest of the project team showed it was raised in plasma from patients with bile acid diarrhea and inflammatory gut diseases.
www.cam.ac.uk/research/new...
Discovery of role of gut hormone in chronic diarrhoea could aid development of new tests and treatments
High levels of a hormone found in cells in the gut could underlie many cases of chronic diarrhoea and help explain up to 40% of cases of patients with
www.cam.ac.uk
July 29, 2025 at 9:08 AM
An article on the Cambridge University website about a challenging peptide I have worked on for over a decade.
@cabannon.bsky.social and the rest of the project team showed it was raised in plasma from patients with bile acid diarrhea and inflammatory gut diseases.
www.cam.ac.uk/research/new...
@cabannon.bsky.social and the rest of the project team showed it was raised in plasma from patients with bile acid diarrhea and inflammatory gut diseases.
www.cam.ac.uk/research/new...
Reposted by Richard Kay
Interview on our published paper last week describing how an identified gut hormone is involved in symptoms of patients with chronic diarrhoea:
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
Discovery of role of gut hormone in chronic diarrhoea could aid development of new tests and treatments
High levels of a hormone found in cells in the gut could underlie many cases of chronic diarrhoea and help explain up to 40% of cases of patients with
www.cam.ac.uk
July 29, 2025 at 7:53 AM
Interview on our published paper last week describing how an identified gut hormone is involved in symptoms of patients with chronic diarrhoea:
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
And here is the paper on INSL5. LC-MS/MS analysis generated similar concentration data compared to an ELISA. The peptide circulates at 100's of pg/mL in disease state, and almost undetectable in control individuals.
My project from my PhD has been published in Gut BMJ today!
The paper highlights an understudied gut hormone INSL5 has a role in chronic diarrhoea, in particular bile acid diarrhoea and a subset of patients with IBS.
@richard-kay.bsky.social
@ims-mrl.bsky.social
gut.bmj.com/content/earl...
The paper highlights an understudied gut hormone INSL5 has a role in chronic diarrhoea, in particular bile acid diarrhoea and a subset of patients with IBS.
@richard-kay.bsky.social
@ims-mrl.bsky.social
gut.bmj.com/content/earl...
Insulin-like peptide 5 is released in response to bile acid in the rectum and is associated with diarrhoea severity in patients with bile acid diarrhoea
Background Insulin-like peptide 5 (INSL5) is an enteroendocrine hormone expressed in distal colonic ‘L cells’. Bile acid receptor agonists are known to stimulate INSL5 secretion in primary cell cultur...
gut.bmj.com
July 24, 2025 at 5:08 PM
And here is the paper on INSL5. LC-MS/MS analysis generated similar concentration data compared to an ELISA. The peptide circulates at 100's of pg/mL in disease state, and almost undetectable in control individuals.
Well - we finally found insulin like peptide 5 in blood using LC-MS/MS. Have been working on this since 2013 - when at my old lab!
It is raised in patients with bile acid diarrhea - and when you dose bile rectally...
Paper just accepted in Gut - will be out soon!
Stil very low ~ 100 pg/mL
It is raised in patients with bile acid diarrhea - and when you dose bile rectally...
Paper just accepted in Gut - will be out soon!
Stil very low ~ 100 pg/mL
July 22, 2025 at 4:34 PM
Well - we finally found insulin like peptide 5 in blood using LC-MS/MS. Have been working on this since 2013 - when at my old lab!
It is raised in patients with bile acid diarrhea - and when you dose bile rectally...
Paper just accepted in Gut - will be out soon!
Stil very low ~ 100 pg/mL
It is raised in patients with bile acid diarrhea - and when you dose bile rectally...
Paper just accepted in Gut - will be out soon!
Stil very low ~ 100 pg/mL
Oh dear... Luckily not my instrument!
July 14, 2025 at 3:31 PM
Oh dear... Luckily not my instrument!
Anyone interested in using mass spectrometry to identify and quantify peptides and proteins in plasma, tissue and organoid cell systems?
I have a Research Assistant position in my lab at the Institute of Metabolic Science - Metabolic Research Laboratories.
Apply here:
lnkd.in/dCxhS3GN
I have a Research Assistant position in my lab at the Institute of Metabolic Science - Metabolic Research Laboratories.
Apply here:
lnkd.in/dCxhS3GN
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
June 11, 2025 at 3:11 PM
Anyone interested in using mass spectrometry to identify and quantify peptides and proteins in plasma, tissue and organoid cell systems?
I have a Research Assistant position in my lab at the Institute of Metabolic Science - Metabolic Research Laboratories.
Apply here:
lnkd.in/dCxhS3GN
I have a Research Assistant position in my lab at the Institute of Metabolic Science - Metabolic Research Laboratories.
Apply here:
lnkd.in/dCxhS3GN
Happy world bike day! 19 mile bike followed by a 5km run with the Ely Tri Club gang. Nice end to the day.
June 4, 2025 at 6:56 PM
Happy world bike day! 19 mile bike followed by a 5km run with the Ely Tri Club gang. Nice end to the day.
It is World Bicycle Day today!!! Glorious but windy here in the Fens. Get out and pedal if you can. Great for fitness and mental health!
June 4, 2025 at 7:26 AM
It is World Bicycle Day today!!! Glorious but windy here in the Fens. Get out and pedal if you can. Great for fitness and mental health!
Question for the triple quad users out there.
Has anyone used the precursor ion scan mode to identify sialic acid containing peptides using the oxonium ion m/z of 274.09 as the product?
Have only used precursor ion scan function twice in 25 years of using mass spectrometers...
#teammassspec
Has anyone used the precursor ion scan mode to identify sialic acid containing peptides using the oxonium ion m/z of 274.09 as the product?
Have only used precursor ion scan function twice in 25 years of using mass spectrometers...
#teammassspec
May 18, 2025 at 5:55 PM
Question for the triple quad users out there.
Has anyone used the precursor ion scan mode to identify sialic acid containing peptides using the oxonium ion m/z of 274.09 as the product?
Have only used precursor ion scan function twice in 25 years of using mass spectrometers...
#teammassspec
Has anyone used the precursor ion scan mode to identify sialic acid containing peptides using the oxonium ion m/z of 274.09 as the product?
Have only used precursor ion scan function twice in 25 years of using mass spectrometers...
#teammassspec
Great to have been part of this research, and good news that trials are underway on drugs to help reduce the symptoms of HG.
This is a very exciting time for research into Hyperemesis Gravidarum (HG) and we are fully supportive of International HG Awareness Day taking place today. #HGProgress #IHGAD25 #HyperemesisGravidarum #PregnancySicknessSupport
May 15, 2025 at 9:41 AM
Great to have been part of this research, and good news that trials are underway on drugs to help reduce the symptoms of HG.
Trains were stuffed back to Ely from Camvridge today, so what should you do??
Go down the pub with friends and talk about mass spectrometry over a few beers!!
Go down the pub with friends and talk about mass spectrometry over a few beers!!
April 29, 2025 at 8:04 PM
Trains were stuffed back to Ely from Camvridge today, so what should you do??
Go down the pub with friends and talk about mass spectrometry over a few beers!!
Go down the pub with friends and talk about mass spectrometry over a few beers!!
An interview of my colleague @cabannon.bsky.social discussing the kind of work we are supporting at the @ims-mrl.bsky.social
Using LC-MS/MS to analyse gut peptides in blood is a real challenge - but a fascinating one.
Hopefully we can use this technique to improve the diagnosis of GI disease.
Using LC-MS/MS to analyse gut peptides in blood is a real challenge - but a fascinating one.
Hopefully we can use this technique to improve the diagnosis of GI disease.
My interview has been published!
Check it out below where I chat about use of AI and machine learning in healthcare research, and how I use it in my research
www.youtube.com/watch?v=NqKd...
@ims-mrl.bsky.social
@richard-kay.bsky.social
@acceleratescience.bsky.social
Check it out below where I chat about use of AI and machine learning in healthcare research, and how I use it in my research
www.youtube.com/watch?v=NqKd...
@ims-mrl.bsky.social
@richard-kay.bsky.social
@acceleratescience.bsky.social
Supervised Learning in Healthcare - Dr Chris Bannon
YouTube video by Accelerate Science
www.youtube.com
April 7, 2025 at 8:43 PM
An interview of my colleague @cabannon.bsky.social discussing the kind of work we are supporting at the @ims-mrl.bsky.social
Using LC-MS/MS to analyse gut peptides in blood is a real challenge - but a fascinating one.
Hopefully we can use this technique to improve the diagnosis of GI disease.
Using LC-MS/MS to analyse gut peptides in blood is a real challenge - but a fascinating one.
Hopefully we can use this technique to improve the diagnosis of GI disease.
Typical.. first time we have had a partial solar eclipse and it's really sunny here in the UK.
Thank heavens for Skymaps..
Mad that so many planets are in view.. maybe the fifth element will be needed soon...
Thank heavens for Skymaps..
Mad that so many planets are in view.. maybe the fifth element will be needed soon...
March 29, 2025 at 10:23 AM
Typical.. first time we have had a partial solar eclipse and it's really sunny here in the UK.
Thank heavens for Skymaps..
Mad that so many planets are in view.. maybe the fifth element will be needed soon...
Thank heavens for Skymaps..
Mad that so many planets are in view.. maybe the fifth element will be needed soon...
Winners of the amino acid quiz at the CamsPaMS Ion Exchange got a unique prize..
A tin of Alphabetti Spaghetti...
Rimmer would not be happy!
A tin of Alphabetti Spaghetti...
Rimmer would not be happy!
March 22, 2025 at 12:58 PM
Winners of the amino acid quiz at the CamsPaMS Ion Exchange got a unique prize..
A tin of Alphabetti Spaghetti...
Rimmer would not be happy!
A tin of Alphabetti Spaghetti...
Rimmer would not be happy!
The first CamsPaMS evening session - The Ion Exchange went off with a bang last night. An amino acid based quiz and ice breaker followed by a proteomics talk and then gut hormone peptidomics talk.
The knitted gut went down well!
Look out for the next one!
The knitted gut went down well!
Look out for the next one!
March 21, 2025 at 6:37 AM
The first CamsPaMS evening session - The Ion Exchange went off with a bang last night. An amino acid based quiz and ice breaker followed by a proteomics talk and then gut hormone peptidomics talk.
The knitted gut went down well!
Look out for the next one!
The knitted gut went down well!
Look out for the next one!
Reposted by Richard Kay
✨ TWO MONTHS TO GO until #pint25 ✨
📍 45 locations across the UK
🔬 Hundreds of passionate scientists and motivated team members
🎯 Bringing science to you
🗓 19th-21st May 2025
Be first to know when tickets go live:
👉 eepurl.com/TbbVX
🗺Locations pintofscience.co.uk
📍 45 locations across the UK
🔬 Hundreds of passionate scientists and motivated team members
🎯 Bringing science to you
🗓 19th-21st May 2025
Be first to know when tickets go live:
👉 eepurl.com/TbbVX
🗺Locations pintofscience.co.uk
March 19, 2025 at 10:47 AM
✨ TWO MONTHS TO GO until #pint25 ✨
📍 45 locations across the UK
🔬 Hundreds of passionate scientists and motivated team members
🎯 Bringing science to you
🗓 19th-21st May 2025
Be first to know when tickets go live:
👉 eepurl.com/TbbVX
🗺Locations pintofscience.co.uk
📍 45 locations across the UK
🔬 Hundreds of passionate scientists and motivated team members
🎯 Bringing science to you
🗓 19th-21st May 2025
Be first to know when tickets go live:
👉 eepurl.com/TbbVX
🗺Locations pintofscience.co.uk
Reposted by Richard Kay
Our Translational Proteomics team is recruiting a Senior Scientist!
We're based in Gaithersburg, MD, USA.
A great opportunity to apply your skills to clinical trial samples, helping to develop new oncology drugs.
Please share!
astrazeneca.wd3.myworkdayjobs.com/Careers/job/...
We're based in Gaithersburg, MD, USA.
A great opportunity to apply your skills to clinical trial samples, helping to develop new oncology drugs.
Please share!
astrazeneca.wd3.myworkdayjobs.com/Careers/job/...
Senior Scientist, Translational Proteomics, Global Mass Spectrometry
Senior Scientist, Translational Proteomics, Mass Spectrometry Introduction to role Do you have a passion for Translational Proteomics and Mass Spectrometry? We are looking for a bold scientist to impa...
astrazeneca.wd3.myworkdayjobs.com
March 18, 2025 at 1:20 PM
Our Translational Proteomics team is recruiting a Senior Scientist!
We're based in Gaithersburg, MD, USA.
A great opportunity to apply your skills to clinical trial samples, helping to develop new oncology drugs.
Please share!
astrazeneca.wd3.myworkdayjobs.com/Careers/job/...
We're based in Gaithersburg, MD, USA.
A great opportunity to apply your skills to clinical trial samples, helping to develop new oncology drugs.
Please share!
astrazeneca.wd3.myworkdayjobs.com/Careers/job/...
The second CamsPaMS conference is fast approaching. Come join your fellow mass spectrometrists at the gorgeous Babraham institute for a free meeting on the 3rd of April.
www.eventbrite.com/e/camspams-2...
www.eventbrite.com/e/camspams-2...
CamsPaMS 2: Cambridge Proteomics and Mass Spectrometry Meeting
CamsPaMS is back! Join us for more talks and networking focused on proteomics and MS taking place in and around Cambridge.
www.eventbrite.com
March 17, 2025 at 9:14 AM
The second CamsPaMS conference is fast approaching. Come join your fellow mass spectrometrists at the gorgeous Babraham institute for a free meeting on the 3rd of April.
www.eventbrite.com/e/camspams-2...
www.eventbrite.com/e/camspams-2...
Reposted by Richard Kay
We have a postdoc position available in our team to undertake a UKRI-funded project to develop a new cultured skeletal muscle model for studying glc metabolism and insulin action. www.jobs.cam.ac.uk/job/50597/ @ims-mrl.bsky.social Please RT. Please email if interested.
Post-doctoral Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Post-doctoral Research Associate (Fixed Term) in the Department of Clinical Biochemistry at the University of Cambridge.
www.jobs.cam.ac.uk
March 12, 2025 at 6:53 PM
We have a postdoc position available in our team to undertake a UKRI-funded project to develop a new cultured skeletal muscle model for studying glc metabolism and insulin action. www.jobs.cam.ac.uk/job/50597/ @ims-mrl.bsky.social Please RT. Please email if interested.
Reposted by Richard Kay
“Words Matter” – Rethinking the Language of Obesity.
Using respectful, non-stigmatizing language (like “people living with obesity” instead of “obese people”) creates a more supportive, science-based conversation. Stigma only makes it harder for people to seek help.
Using respectful, non-stigmatizing language (like “people living with obesity” instead of “obese people”) creates a more supportive, science-based conversation. Stigma only makes it harder for people to seek help.
March 4, 2025 at 5:07 PM
“Words Matter” – Rethinking the Language of Obesity.
Using respectful, non-stigmatizing language (like “people living with obesity” instead of “obese people”) creates a more supportive, science-based conversation. Stigma only makes it harder for people to seek help.
Using respectful, non-stigmatizing language (like “people living with obesity” instead of “obese people”) creates a more supportive, science-based conversation. Stigma only makes it harder for people to seek help.