Abhilasha Joshi, PhD
@rhythmicspikes.bsky.social
Neuroscientist studying interactions between cognition, action & timing
Lab website: neuroact.in
Group Leader | NeuroACTLab @NCBS_Bangalore | SCAgingBrain fellow ➡️ faculty | Previously: @Neuro_CF @UCSF @UniofOxford @IiserMohali
Lab website: neuroact.in
Group Leader | NeuroACTLab @NCBS_Bangalore | SCAgingBrain fellow ➡️ faculty | Previously: @Neuro_CF @UCSF @UniofOxford @IiserMohali
Beautiful work by #AbhishekBhattacharya at @ncbsbangalore.bsky.social on their discoveries led by graduate student Atal Vats. Impressive body of work 🦾 on structure, regulation and function of heterochannel electrical synapses.
Check recently preprinted work ➡️ www.biorxiv.org/content/10.1...
🪱
Check recently preprinted work ➡️ www.biorxiv.org/content/10.1...
🪱
October 30, 2025 at 9:38 AM
Beautiful work by #AbhishekBhattacharya at @ncbsbangalore.bsky.social on their discoveries led by graduate student Atal Vats. Impressive body of work 🦾 on structure, regulation and function of heterochannel electrical synapses.
Check recently preprinted work ➡️ www.biorxiv.org/content/10.1...
🪱
Check recently preprinted work ➡️ www.biorxiv.org/content/10.1...
🪱
Great talk by @leenaibrahim.bsky.social from KAUST on her beautiful work characterising the L1 and L4 interneurons and how they differ based on sensory and other inputs and connections 👏🏽
Great to have her visit at #IndianAcademyofNeuroscinces meeting in Kovalum 😎
www.kaust.edu.sa/study/faculty
Great to have her visit at #IndianAcademyofNeuroscinces meeting in Kovalum 😎
www.kaust.edu.sa/study/faculty
October 30, 2025 at 9:01 AM
Great talk by @leenaibrahim.bsky.social from KAUST on her beautiful work characterising the L1 and L4 interneurons and how they differ based on sensory and other inputs and connections 👏🏽
Great to have her visit at #IndianAcademyofNeuroscinces meeting in Kovalum 😎
www.kaust.edu.sa/study/faculty
Great to have her visit at #IndianAcademyofNeuroscinces meeting in Kovalum 😎
www.kaust.edu.sa/study/faculty
What an excellent read ✅👏🏽
Highly recommend! I loved how the author (Evelyn Fox Keller) really dived deep into the concept of “understanding” or a feeling for the organism and on the role of “intuition” in making discoveries.
A lot to think about too: few permanent positions, science in war …!
Highly recommend! I loved how the author (Evelyn Fox Keller) really dived deep into the concept of “understanding” or a feeling for the organism and on the role of “intuition” in making discoveries.
A lot to think about too: few permanent positions, science in war …!
September 24, 2025 at 2:29 PM
What an excellent read ✅👏🏽
Highly recommend! I loved how the author (Evelyn Fox Keller) really dived deep into the concept of “understanding” or a feeling for the organism and on the role of “intuition” in making discoveries.
A lot to think about too: few permanent positions, science in war …!
Highly recommend! I loved how the author (Evelyn Fox Keller) really dived deep into the concept of “understanding” or a feeling for the organism and on the role of “intuition” in making discoveries.
A lot to think about too: few permanent positions, science in war …!
16/
We’d love your feedback and thoughts on this work. Please read, share, & test the code and let us know what you think. 💬
📄 Paper: www.biorxiv.org/content/10.1...
💻 Code: github.com/LorenFrankLa...
We’d love your feedback and thoughts on this work. Please read, share, & test the code and let us know what you think. 💬
📄 Paper: www.biorxiv.org/content/10.1...
💻 Code: github.com/LorenFrankLa...
September 17, 2025 at 7:33 PM
16/
We’d love your feedback and thoughts on this work. Please read, share, & test the code and let us know what you think. 💬
📄 Paper: www.biorxiv.org/content/10.1...
💻 Code: github.com/LorenFrankLa...
We’d love your feedback and thoughts on this work. Please read, share, & test the code and let us know what you think. 💬
📄 Paper: www.biorxiv.org/content/10.1...
💻 Code: github.com/LorenFrankLa...
11/
Notably, despite #replay being #preserved, learning deficits were as severe [see snippet of Figure 3a shown below] as those observed in a complete hippocampal lesion (Kim & Frank, 2009).
💡💡
Notably, despite #replay being #preserved, learning deficits were as severe [see snippet of Figure 3a shown below] as those observed in a complete hippocampal lesion (Kim & Frank, 2009).
💡💡
September 17, 2025 at 7:33 PM
11/
Notably, despite #replay being #preserved, learning deficits were as severe [see snippet of Figure 3a shown below] as those observed in a complete hippocampal lesion (Kim & Frank, 2009).
💡💡
Notably, despite #replay being #preserved, learning deficits were as severe [see snippet of Figure 3a shown below] as those observed in a complete hippocampal lesion (Kim & Frank, 2009).
💡💡
10/
What about #replay?
✅ Replay rate - intact
✅ Replay length - intact
✅ Replay content - intact
✅ Replay speed - intact
Neural activity patterns during immobility remained unchanged. See a beautiful example of a continuous replay in targeted animals: Fig. 5
What about #replay?
✅ Replay rate - intact
✅ Replay length - intact
✅ Replay content - intact
✅ Replay speed - intact
Neural activity patterns during immobility remained unchanged. See a beautiful example of a continuous replay in targeted animals: Fig. 5
September 17, 2025 at 7:33 PM
10/
What about #replay?
✅ Replay rate - intact
✅ Replay length - intact
✅ Replay content - intact
✅ Replay speed - intact
Neural activity patterns during immobility remained unchanged. See a beautiful example of a continuous replay in targeted animals: Fig. 5
What about #replay?
✅ Replay rate - intact
✅ Replay length - intact
✅ Replay content - intact
✅ Replay speed - intact
Neural activity patterns during immobility remained unchanged. See a beautiful example of a continuous replay in targeted animals: Fig. 5
7/
👉🏽 We found that #closedLoop theta-phase stimulation of MS-PV neurons caused a rapid reduction of theta power during locomotion [Fig 1].
✅ Animals ran just fine (velocity & #trials matched between targeted and control subjects).
👉🏽 We found that #closedLoop theta-phase stimulation of MS-PV neurons caused a rapid reduction of theta power during locomotion [Fig 1].
✅ Animals ran just fine (velocity & #trials matched between targeted and control subjects).
September 17, 2025 at 7:33 PM
7/
👉🏽 We found that #closedLoop theta-phase stimulation of MS-PV neurons caused a rapid reduction of theta power during locomotion [Fig 1].
✅ Animals ran just fine (velocity & #trials matched between targeted and control subjects).
👉🏽 We found that #closedLoop theta-phase stimulation of MS-PV neurons caused a rapid reduction of theta power during locomotion [Fig 1].
✅ Animals ran just fine (velocity & #trials matched between targeted and control subjects).
6/
What did we do?
We used reliable PV-expressing neurons of the medial septum (#MS) and developed a closed loop #theta-phase–specific manipulation of hippocampal neural dynamics selectively during #locomotion.
👉 Both across-animal & within-animal controls included!
What did we do?
We used reliable PV-expressing neurons of the medial septum (#MS) and developed a closed loop #theta-phase–specific manipulation of hippocampal neural dynamics selectively during #locomotion.
👉 Both across-animal & within-animal controls included!
September 17, 2025 at 7:33 PM
6/
What did we do?
We used reliable PV-expressing neurons of the medial septum (#MS) and developed a closed loop #theta-phase–specific manipulation of hippocampal neural dynamics selectively during #locomotion.
👉 Both across-animal & within-animal controls included!
What did we do?
We used reliable PV-expressing neurons of the medial septum (#MS) and developed a closed loop #theta-phase–specific manipulation of hippocampal neural dynamics selectively during #locomotion.
👉 Both across-animal & within-animal controls included!
3/ (aside)
Why focus on #locomotion? 👀
We see gorgeous spatial sequences ('theta sequences') while animals move (data example below from Joshi et al., 2023). These are thought to support #learning, but disrupting them *specifically during locomotion* has been hard.
Why focus on #locomotion? 👀
We see gorgeous spatial sequences ('theta sequences') while animals move (data example below from Joshi et al., 2023). These are thought to support #learning, but disrupting them *specifically during locomotion* has been hard.
September 17, 2025 at 7:33 PM
3/ (aside)
Why focus on #locomotion? 👀
We see gorgeous spatial sequences ('theta sequences') while animals move (data example below from Joshi et al., 2023). These are thought to support #learning, but disrupting them *specifically during locomotion* has been hard.
Why focus on #locomotion? 👀
We see gorgeous spatial sequences ('theta sequences') while animals move (data example below from Joshi et al., 2023). These are thought to support #learning, but disrupting them *specifically during locomotion* has been hard.
1/
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
September 17, 2025 at 7:33 PM
1/
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
2/ When the book arrived, I realized it was second-hand, came from a thrift store all the way from US (!) and was stamped with the name Karen Wetterhahn.
👀
👀
September 14, 2025 at 5:34 PM
2/ When the book arrived, I realized it was second-hand, came from a thrift store all the way from US (!) and was stamped with the name Karen Wetterhahn.
👀
👀
1/ Something surreal happened to me recently 🍀
I ordered “A Feeling for the Organism” — Evelyn Fox Keller’s biography of #BarbaraMcClintock, the 1983 Nobel prize winner who discovered “jumping genes.” 🧬
I ordered “A Feeling for the Organism” — Evelyn Fox Keller’s biography of #BarbaraMcClintock, the 1983 Nobel prize winner who discovered “jumping genes.” 🧬
September 14, 2025 at 5:34 PM
1/ Something surreal happened to me recently 🍀
I ordered “A Feeling for the Organism” — Evelyn Fox Keller’s biography of #BarbaraMcClintock, the 1983 Nobel prize winner who discovered “jumping genes.” 🧬
I ordered “A Feeling for the Organism” — Evelyn Fox Keller’s biography of #BarbaraMcClintock, the 1983 Nobel prize winner who discovered “jumping genes.” 🧬
📣 We are expanding! Repost 🙏🏽
- Postdoc (funded by @simonsfoundation.org grant on synchronisation between cognitive representations and stepping)
- Project Associates
- Create your role! (Reach out if you are keen on these topics and these roles do not define you 👀🤗)
www.neuroact.in
- Postdoc (funded by @simonsfoundation.org grant on synchronisation between cognitive representations and stepping)
- Project Associates
- Create your role! (Reach out if you are keen on these topics and these roles do not define you 👀🤗)
www.neuroact.in
August 1, 2025 at 12:22 PM
📣 We are expanding! Repost 🙏🏽
- Postdoc (funded by @simonsfoundation.org grant on synchronisation between cognitive representations and stepping)
- Project Associates
- Create your role! (Reach out if you are keen on these topics and these roles do not define you 👀🤗)
www.neuroact.in
- Postdoc (funded by @simonsfoundation.org grant on synchronisation between cognitive representations and stepping)
- Project Associates
- Create your role! (Reach out if you are keen on these topics and these roles do not define you 👀🤗)
www.neuroact.in
🤓
Having a great time interacting with participants at the #Computational Approaches to #Memory and #Plasticity at the beautiful IISER campus in Pune. I am teaching the modules on #rhythms and #oscillations at the neural and behavioural scales 🧠🐀
campiiser.com/2025/
#neuroskyence #neuroscience
Having a great time interacting with participants at the #Computational Approaches to #Memory and #Plasticity at the beautiful IISER campus in Pune. I am teaching the modules on #rhythms and #oscillations at the neural and behavioural scales 🧠🐀
campiiser.com/2025/
#neuroskyence #neuroscience
July 12, 2025 at 6:26 AM
🤓
Having a great time interacting with participants at the #Computational Approaches to #Memory and #Plasticity at the beautiful IISER campus in Pune. I am teaching the modules on #rhythms and #oscillations at the neural and behavioural scales 🧠🐀
campiiser.com/2025/
#neuroskyence #neuroscience
Having a great time interacting with participants at the #Computational Approaches to #Memory and #Plasticity at the beautiful IISER campus in Pune. I am teaching the modules on #rhythms and #oscillations at the neural and behavioural scales 🧠🐀
campiiser.com/2025/
#neuroskyence #neuroscience
Enjoying reading Nachum Ulyanovsky’s book #NaturalNeuroscience 🤓
[[ So excited see our work on the synchronisation between #steps and #hippocampal representations featured here 🤩
How cognitive processes interact with actions is the goal we are working towards. Natural behavior is necessary 🙌🏽 ]]
[[ So excited see our work on the synchronisation between #steps and #hippocampal representations featured here 🤩
How cognitive processes interact with actions is the goal we are working towards. Natural behavior is necessary 🙌🏽 ]]
June 21, 2025 at 6:06 AM
Enjoying reading Nachum Ulyanovsky’s book #NaturalNeuroscience 🤓
[[ So excited see our work on the synchronisation between #steps and #hippocampal representations featured here 🤩
How cognitive processes interact with actions is the goal we are working towards. Natural behavior is necessary 🙌🏽 ]]
[[ So excited see our work on the synchronisation between #steps and #hippocampal representations featured here 🤩
How cognitive processes interact with actions is the goal we are working towards. Natural behavior is necessary 🙌🏽 ]]
That’s all from me this time. I fly back to India with my heart full. Was a pleasure to play a small part in organising this meeting with @vitorlds.bsky.social Andressa and Carro 👑👑👑
April 15, 2025 at 2:03 PM
That’s all from me this time. I fly back to India with my heart full. Was a pleasure to play a small part in organising this meeting with @vitorlds.bsky.social Andressa and Carro 👑👑👑
The real stars of the show were students (undergraduates, masters and PhD) who brought real energy to the meeting with their enthusiasm and discussion 😻
April 15, 2025 at 2:03 PM
The real stars of the show were students (undergraduates, masters and PhD) who brought real energy to the meeting with their enthusiasm and discussion 😻
It’s a wrap 🙇🏽♀️
I really enjoyed the 5 days of #discussion on #NeuralMechanismsOfCognitiveFunction.
One of the most #inspiring #neuroscience meetings I’ve ever attended 😇
#neuroscience #inclusion #globalsouth
I really enjoyed the 5 days of #discussion on #NeuralMechanismsOfCognitiveFunction.
One of the most #inspiring #neuroscience meetings I’ve ever attended 😇
#neuroscience #inclusion #globalsouth
April 15, 2025 at 1:53 PM
It’s a wrap 🙇🏽♀️
I really enjoyed the 5 days of #discussion on #NeuralMechanismsOfCognitiveFunction.
One of the most #inspiring #neuroscience meetings I’ve ever attended 😇
#neuroscience #inclusion #globalsouth
I really enjoyed the 5 days of #discussion on #NeuralMechanismsOfCognitiveFunction.
One of the most #inspiring #neuroscience meetings I’ve ever attended 😇
#neuroscience #inclusion #globalsouth
Talk 19:
Next up is @acnavasolive.bsky.social talking about her impressive research on sharp wave ripple analysis across species in health and disease. Andrea is a phenomenal computational neuroscientist 🤩 and I am so excited to hear her speak for the first time!
Next up is @acnavasolive.bsky.social talking about her impressive research on sharp wave ripple analysis across species in health and disease. Andrea is a phenomenal computational neuroscientist 🤩 and I am so excited to hear her speak for the first time!
April 14, 2025 at 5:52 PM
Talk 19:
Next up is @acnavasolive.bsky.social talking about her impressive research on sharp wave ripple analysis across species in health and disease. Andrea is a phenomenal computational neuroscientist 🤩 and I am so excited to hear her speak for the first time!
Next up is @acnavasolive.bsky.social talking about her impressive research on sharp wave ripple analysis across species in health and disease. Andrea is a phenomenal computational neuroscientist 🤩 and I am so excited to hear her speak for the first time!
Cont ..
@nikolaskaralis.bsky.social talking about potential role of #breathing in facilitating neural communication during sleep, including inducing transient #apnea during optogenetic manipulations 🙆🏽♀️ 👏🏽
@nikolaskaralis.bsky.social talking about potential role of #breathing in facilitating neural communication during sleep, including inducing transient #apnea during optogenetic manipulations 🙆🏽♀️ 👏🏽
April 14, 2025 at 2:50 PM
Cont ..
@nikolaskaralis.bsky.social talking about potential role of #breathing in facilitating neural communication during sleep, including inducing transient #apnea during optogenetic manipulations 🙆🏽♀️ 👏🏽
@nikolaskaralis.bsky.social talking about potential role of #breathing in facilitating neural communication during sleep, including inducing transient #apnea during optogenetic manipulations 🙆🏽♀️ 👏🏽
Talk 18:
Next up is @nikolaskaralis.bsky.social sharing his research about the #neuromodulatory architecture of neuronal #circuits and how are brain states implemented 👀
Check out his lab website: www.neuronaldynamics.eu/team/nikolas
Next up is @nikolaskaralis.bsky.social sharing his research about the #neuromodulatory architecture of neuronal #circuits and how are brain states implemented 👀
Check out his lab website: www.neuronaldynamics.eu/team/nikolas
April 14, 2025 at 2:40 PM
Talk 18:
Next up is @nikolaskaralis.bsky.social sharing his research about the #neuromodulatory architecture of neuronal #circuits and how are brain states implemented 👀
Check out his lab website: www.neuronaldynamics.eu/team/nikolas
Next up is @nikolaskaralis.bsky.social sharing his research about the #neuromodulatory architecture of neuronal #circuits and how are brain states implemented 👀
Check out his lab website: www.neuronaldynamics.eu/team/nikolas
Talk 17:
@smikulovic.bsky.social talking about how he work led in her lab about neural mechanisms underlying #helping in mice.
Such a unique research direction. looking forward to her talk. 🤓
@smikulovic.bsky.social talking about how he work led in her lab about neural mechanisms underlying #helping in mice.
Such a unique research direction. looking forward to her talk. 🤓
April 14, 2025 at 1:51 PM
Talk 17:
@smikulovic.bsky.social talking about how he work led in her lab about neural mechanisms underlying #helping in mice.
Such a unique research direction. looking forward to her talk. 🤓
@smikulovic.bsky.social talking about how he work led in her lab about neural mechanisms underlying #helping in mice.
Such a unique research direction. looking forward to her talk. 🤓
Day 5 has an exciting lineup 🤩
@smikulovic.bsky.social talks about helping mice
@nikolaskaralis.bsky.social neuromodulatory circuits
@acnavasolive.bsky.social SWR across species
And me 💁🏽♀️ about theta & movement
#neuroscience
#NeuralMechanismsofCognitiveFunction
sites.google.com/isd.org.br/i...
@smikulovic.bsky.social talks about helping mice
@nikolaskaralis.bsky.social neuromodulatory circuits
@acnavasolive.bsky.social SWR across species
And me 💁🏽♀️ about theta & movement
#neuroscience
#NeuralMechanismsofCognitiveFunction
sites.google.com/isd.org.br/i...
April 14, 2025 at 1:40 PM
Day 5 has an exciting lineup 🤩
@smikulovic.bsky.social talks about helping mice
@nikolaskaralis.bsky.social neuromodulatory circuits
@acnavasolive.bsky.social SWR across species
And me 💁🏽♀️ about theta & movement
#neuroscience
#NeuralMechanismsofCognitiveFunction
sites.google.com/isd.org.br/i...
@smikulovic.bsky.social talks about helping mice
@nikolaskaralis.bsky.social neuromodulatory circuits
@acnavasolive.bsky.social SWR across species
And me 💁🏽♀️ about theta & movement
#neuroscience
#NeuralMechanismsofCognitiveFunction
sites.google.com/isd.org.br/i...
cont ..
Samira explaining the experimental paradigm to study the effect of sex chromosomes versus gonadal hormones on cognitive function.
Samira is a @simonsfoundation.org #FellowstoFaculty awardee who will study the role of parental origin of X.
www.simonsfoundation.org/people/samir...
👏🏽⭐️
Samira explaining the experimental paradigm to study the effect of sex chromosomes versus gonadal hormones on cognitive function.
Samira is a @simonsfoundation.org #FellowstoFaculty awardee who will study the role of parental origin of X.
www.simonsfoundation.org/people/samir...
👏🏽⭐️
April 13, 2025 at 6:51 PM
cont ..
Samira explaining the experimental paradigm to study the effect of sex chromosomes versus gonadal hormones on cognitive function.
Samira is a @simonsfoundation.org #FellowstoFaculty awardee who will study the role of parental origin of X.
www.simonsfoundation.org/people/samir...
👏🏽⭐️
Samira explaining the experimental paradigm to study the effect of sex chromosomes versus gonadal hormones on cognitive function.
Samira is a @simonsfoundation.org #FellowstoFaculty awardee who will study the role of parental origin of X.
www.simonsfoundation.org/people/samir...
👏🏽⭐️