Richard Held
@rgsheld.bsky.social
Neuroscientist / synaptic physiologist interested in protein topography and cellular signal transduction. Ephys in the past, cryoET now, mouse genetics forever.
https://scholar.google.com/citations?hl=en&user=ESpBK1AAAAAJ
https://scholar.google.com/citations?hl=en&user=ESpBK1AAAAAJ
Clearly a poorly resolved flexible domain here
November 18, 2025 at 12:40 AM
Clearly a poorly resolved flexible domain here
I think about this tweet on a near-daily basis
October 9, 2025 at 4:11 PM
I think about this tweet on a near-daily basis
This is what made America great
October 8, 2025 at 4:41 PM
This is what made America great
Heart rate data or RC voltage step?
August 8, 2025 at 3:14 PM
Heart rate data or RC voltage step?
A formidable opponent in the fight against productivity.
June 2, 2025 at 7:25 PM
A formidable opponent in the fight against productivity.
Ok microtubule people, what is going on here? Cross section projection images, two different areas and surrounded by intact microtubules:
May 13, 2025 at 4:30 PM
Ok microtubule people, what is going on here? Cross section projection images, two different areas and surrounded by intact microtubules:
Could run this article for every flight he takes
March 28, 2025 at 6:48 PM
Could run this article for every flight he takes
Somewhere between this Derek Lowe quote and the Kendrick halftime show, you will find my current vibe
February 21, 2025 at 7:34 PM
Somewhere between this Derek Lowe quote and the Kendrick halftime show, you will find my current vibe
Life is offering up an abundance of lemons, therefore:
February 13, 2025 at 12:33 AM
Life is offering up an abundance of lemons, therefore:
So nobody wants to fly to Frankfurt on a Monday in February, I guess...
February 3, 2025 at 9:09 PM
So nobody wants to fly to Frankfurt on a Monday in February, I guess...
Thinking a lot about "what ifs" inspired mostly by current chaos. Unearthed my biggest alternative life:
January 23, 2025 at 5:42 PM
Thinking a lot about "what ifs" inspired mostly by current chaos. Unearthed my biggest alternative life:
My new years resolution is to realize a longstanding goal of achieving one of the two ideal body types:
January 1, 2025 at 1:05 AM
My new years resolution is to realize a longstanding goal of achieving one of the two ideal body types:
We all unwind differently after a long day, I guess
December 21, 2024 at 3:35 AM
We all unwind differently after a long day, I guess
FIB perspective lamellae = Rothko paintings
December 17, 2024 at 2:16 PM
FIB perspective lamellae = Rothko paintings
Adobe generative fill...no notes.
December 3, 2024 at 9:19 PM
Adobe generative fill...no notes.
She is obsessed with this possum
December 2, 2024 at 1:39 AM
She is obsessed with this possum
Put my thumb through one side and burned myself on the flip, but all told a success for 2024 standards 🤷♂️
November 29, 2024 at 1:38 AM
Put my thumb through one side and burned myself on the flip, but all told a success for 2024 standards 🤷♂️
Is there such thing as TEMTuesday? Maybe CryoETuesday? Myelinated axon cross section with microtubules and intermediate filaments:
November 26, 2024 at 6:50 PM
Is there such thing as TEMTuesday? Maybe CryoETuesday? Myelinated axon cross section with microtubules and intermediate filaments:
Ok I will strive to make this account more science focused but come on:
November 14, 2024 at 10:50 PM
Ok I will strive to make this account more science focused but come on:
Check out a recent preprint here:
www.biorxiv.org/content/10.1...
We used GluA2 knock-in mice localize synaptic AMPARs, revealing an 'exclusion zone' relationship between synaptic vesicles and clustered AMPARs and the in-situ structure of the scaffolding interaction between AMPARs and PSD-95.
www.biorxiv.org/content/10.1...
We used GluA2 knock-in mice localize synaptic AMPARs, revealing an 'exclusion zone' relationship between synaptic vesicles and clustered AMPARs and the in-situ structure of the scaffolding interaction between AMPARs and PSD-95.
November 13, 2024 at 6:06 PM
Check out a recent preprint here:
www.biorxiv.org/content/10.1...
We used GluA2 knock-in mice localize synaptic AMPARs, revealing an 'exclusion zone' relationship between synaptic vesicles and clustered AMPARs and the in-situ structure of the scaffolding interaction between AMPARs and PSD-95.
www.biorxiv.org/content/10.1...
We used GluA2 knock-in mice localize synaptic AMPARs, revealing an 'exclusion zone' relationship between synaptic vesicles and clustered AMPARs and the in-situ structure of the scaffolding interaction between AMPARs and PSD-95.
Reintro: I'm a neuroscientist interested in how cells use molecular topography to control signal transduction. I use #CryoET and mouse genetic tools to map the topography of synaptic proteins and determine in-situ structures of scaffolding interactions that control said topography.
November 13, 2024 at 6:06 PM
Reintro: I'm a neuroscientist interested in how cells use molecular topography to control signal transduction. I use #CryoET and mouse genetic tools to map the topography of synaptic proteins and determine in-situ structures of scaffolding interactions that control said topography.
My high(low?)light reel contribution:
November 12, 2024 at 2:41 PM
My high(low?)light reel contribution: