Anatomic Incorporated
@real-anatomic.bsky.social
Stem cell focused research with applications in pain, ALS, CMT, and cancer drug discovery. Recreating in vitro models one cell type at a time.
🎥 A glimpse into our 7-day directed differentiation of human iPSC-derived dorsal horn neurons. Fast. Reproducible. Ready for pain pathway discovery.
#NotYourAverageNeuron #CompleteTheCircuit #neuroscience #drugdiscovery #iPSC #dorsalhorn #painresearch
#NotYourAverageNeuron #CompleteTheCircuit #neuroscience #drugdiscovery #iPSC #dorsalhorn #painresearch
June 18, 2025 at 12:58 PM
🎥 A glimpse into our 7-day directed differentiation of human iPSC-derived dorsal horn neurons. Fast. Reproducible. Ready for pain pathway discovery.
#NotYourAverageNeuron #CompleteTheCircuit #neuroscience #drugdiscovery #iPSC #dorsalhorn #painresearch
#NotYourAverageNeuron #CompleteTheCircuit #neuroscience #drugdiscovery #iPSC #dorsalhorn #painresearch
Motor neurons alone can't explain ALS or CMT. Schwann Cell Precursors reveal how disrupted glial-neuronal crosstalk drives disease. Co-cultures model early pathogenesis, glial dysfunction, and myelination defects more accurately.
#CompleteTheCircuit #NotYourAverageNeuron
#CompleteTheCircuit #NotYourAverageNeuron
June 6, 2025 at 12:56 PM
Motor neurons alone can't explain ALS or CMT. Schwann Cell Precursors reveal how disrupted glial-neuronal crosstalk drives disease. Co-cultures model early pathogenesis, glial dysfunction, and myelination defects more accurately.
#CompleteTheCircuit #NotYourAverageNeuron
#CompleteTheCircuit #NotYourAverageNeuron
💡 Unlike chemo drugs that damage DNA, Bortezomib disrupts mitochondrial function and protein balance in nerves.
RealDRG™ hiPSC-derived sensory neurons show dose-dependent cytotoxicity to Bortezomib—highlighting their value for CIPN research.
#CIPN #PainResearch #RealDRG #DrugDiscovery
RealDRG™ hiPSC-derived sensory neurons show dose-dependent cytotoxicity to Bortezomib—highlighting their value for CIPN research.
#CIPN #PainResearch #RealDRG #DrugDiscovery
May 30, 2025 at 12:40 PM
💡 Unlike chemo drugs that damage DNA, Bortezomib disrupts mitochondrial function and protein balance in nerves.
RealDRG™ hiPSC-derived sensory neurons show dose-dependent cytotoxicity to Bortezomib—highlighting their value for CIPN research.
#CIPN #PainResearch #RealDRG #DrugDiscovery
RealDRG™ hiPSC-derived sensory neurons show dose-dependent cytotoxicity to Bortezomib—highlighting their value for CIPN research.
#CIPN #PainResearch #RealDRG #DrugDiscovery
Add These Publications to Your Reading List 📚
Explore all publications featuring Anatomic’s products in one place — a fast way to find relevant assays and new applications.
See how our models are advancing discovery: www.anatomic.com/publications
#CompleteTheCircuit #NotYourAverageNeuron
Explore all publications featuring Anatomic’s products in one place — a fast way to find relevant assays and new applications.
See how our models are advancing discovery: www.anatomic.com/publications
#CompleteTheCircuit #NotYourAverageNeuron
Publications | Anatomic
www.anatomic.com
May 27, 2025 at 2:18 PM
Add These Publications to Your Reading List 📚
Explore all publications featuring Anatomic’s products in one place — a fast way to find relevant assays and new applications.
See how our models are advancing discovery: www.anatomic.com/publications
#CompleteTheCircuit #NotYourAverageNeuron
Explore all publications featuring Anatomic’s products in one place — a fast way to find relevant assays and new applications.
See how our models are advancing discovery: www.anatomic.com/publications
#CompleteTheCircuit #NotYourAverageNeuron
The Kolber Lab at UTD has launched a core facility with a high-content analgesic screening assay using the Axion Maestro Pro, now featured in their latest publication.
Read the article here: www.cell.com/cell-reports...
Read the article here: www.cell.com/cell-reports...
Profiling human iPSC-derived sensory neurons for analgesic drug screening using a multi-electrode array
Fofie et al. present a high-content screening platform using hiPSC-derived nociceptors
cultured on multi-well multielectrode arrays to identify peripheral analgesics with
diverse mechanisms of action....
www.cell.com
May 23, 2025 at 1:31 PM
The Kolber Lab at UTD has launched a core facility with a high-content analgesic screening assay using the Axion Maestro Pro, now featured in their latest publication.
Read the article here: www.cell.com/cell-reports...
Read the article here: www.cell.com/cell-reports...
Team Anatomic hit the pavement together for the #Walk4CMT 💙 Grateful to be part of a community that's raising awareness, showing support, and walking toward a cure. Huge thanks to everyone who came out and walked with us and to CMTA for putting on a well organized and meaningful event.
May 20, 2025 at 2:21 PM
Team Anatomic hit the pavement together for the #Walk4CMT 💙 Grateful to be part of a community that's raising awareness, showing support, and walking toward a cure. Huge thanks to everyone who came out and walked with us and to CMTA for putting on a well organized and meaningful event.
Exciting synaptic insights! 🟢
Using Anatomic’s nociceptors & dorsal horn neurons, VGLUT2 (green) shows glutamate at synapses, while TUJ1 (red) highlights neurons.
#CompleteTheCircuit #SensoryNeurons #PainResearch #DorsalHornNeurons #NotYourAverageNeuron
Using Anatomic’s nociceptors & dorsal horn neurons, VGLUT2 (green) shows glutamate at synapses, while TUJ1 (red) highlights neurons.
#CompleteTheCircuit #SensoryNeurons #PainResearch #DorsalHornNeurons #NotYourAverageNeuron
April 25, 2025 at 2:55 PM
Exciting synaptic insights! 🟢
Using Anatomic’s nociceptors & dorsal horn neurons, VGLUT2 (green) shows glutamate at synapses, while TUJ1 (red) highlights neurons.
#CompleteTheCircuit #SensoryNeurons #PainResearch #DorsalHornNeurons #NotYourAverageNeuron
Using Anatomic’s nociceptors & dorsal horn neurons, VGLUT2 (green) shows glutamate at synapses, while TUJ1 (red) highlights neurons.
#CompleteTheCircuit #SensoryNeurons #PainResearch #DorsalHornNeurons #NotYourAverageNeuron
Keepin’ it local🤙🏼We attended the 3rd Minnesota Organoid Symposium put on by the University of Minnesota and Mayo Clinic earlier this week. Big shoutout to our Scitech intern Devanshi, who gave her first poster presentation!
#NotYourAverageNeuron #CIPN #StemCells
#NotYourAverageNeuron #CIPN #StemCells
April 11, 2025 at 2:48 PM
Keepin’ it local🤙🏼We attended the 3rd Minnesota Organoid Symposium put on by the University of Minnesota and Mayo Clinic earlier this week. Big shoutout to our Scitech intern Devanshi, who gave her first poster presentation!
#NotYourAverageNeuron #CIPN #StemCells
#NotYourAverageNeuron #CIPN #StemCells
🌉 Hello, San Francisco! Catch Vincent Truong at the Axion BioSystems World Tour on April 17! He’ll share how advanced hiPSC-based models are transforming #pain, #ALS & #CMT research.
🔗 Register now → axionbiosystems.com/axion-world-...
#AxionWorldTour #hiPSC #Neuroscience #NotYourAverageNeuron
🔗 Register now → axionbiosystems.com/axion-world-...
#AxionWorldTour #hiPSC #Neuroscience #NotYourAverageNeuron
April 4, 2025 at 2:24 PM
🌉 Hello, San Francisco! Catch Vincent Truong at the Axion BioSystems World Tour on April 17! He’ll share how advanced hiPSC-based models are transforming #pain, #ALS & #CMT research.
🔗 Register now → axionbiosystems.com/axion-world-...
#AxionWorldTour #hiPSC #Neuroscience #NotYourAverageNeuron
🔗 Register now → axionbiosystems.com/axion-world-...
#AxionWorldTour #hiPSC #Neuroscience #NotYourAverageNeuron
💡 Integrating Schwann cell precursors (SCPs) into motor neuron (MN) cultures enhances relevance by replicating human physiology. As SCPs mature, they migrate and align along axons, visualized via S100b/SOX10 (SCPs) and TUJ1 (MNs) staining.
#CompleteTheCircuit #NotYourAverageNeuron #ALSResearch
#CompleteTheCircuit #NotYourAverageNeuron #ALSResearch
March 28, 2025 at 12:34 PM
💡 Integrating Schwann cell precursors (SCPs) into motor neuron (MN) cultures enhances relevance by replicating human physiology. As SCPs mature, they migrate and align along axons, visualized via S100b/SOX10 (SCPs) and TUJ1 (MNs) staining.
#CompleteTheCircuit #NotYourAverageNeuron #ALSResearch
#CompleteTheCircuit #NotYourAverageNeuron #ALSResearch
Anatomic has been focused on developing CIPN-related assays for the last few years. The FDA’s new draft guidance underscores the need for better study designs and endpoints in CIPN research.
Read the full guidance below!
#CompleteTheCircuit #CIPNResearch
Read the full guidance below!
#CompleteTheCircuit #CIPNResearch
March 24, 2025 at 2:27 PM
Anatomic has been focused on developing CIPN-related assays for the last few years. The FDA’s new draft guidance underscores the need for better study designs and endpoints in CIPN research.
Read the full guidance below!
#CompleteTheCircuit #CIPNResearch
Read the full guidance below!
#CompleteTheCircuit #CIPNResearch
💎Check-out the purity💎 Images of co-cultures of RealSCP, hiPSC-derived Schwann cell precursors, and RealDRG, hiPSC-derived sensory neurons, generated without the need for genetic engineering or Mitomycin C.
#CompleteTheCircuit #NotYourAverageNeuron
#CompleteTheCircuit #NotYourAverageNeuron
March 18, 2025 at 2:03 PM
💎Check-out the purity💎 Images of co-cultures of RealSCP, hiPSC-derived Schwann cell precursors, and RealDRG, hiPSC-derived sensory neurons, generated without the need for genetic engineering or Mitomycin C.
#CompleteTheCircuit #NotYourAverageNeuron
#CompleteTheCircuit #NotYourAverageNeuron
It’s always tough to pick favorites when there’s so much exciting data to explore! 🤩 We have compiled our favorite data from over the years onto a new page for your easy access.
Check out our data highlights page at www.anatomic.com/datahighlights
#CompleteTheCircuit #NotYourAverageNeuron
Check out our data highlights page at www.anatomic.com/datahighlights
#CompleteTheCircuit #NotYourAverageNeuron
March 14, 2025 at 12:59 PM
It’s always tough to pick favorites when there’s so much exciting data to explore! 🤩 We have compiled our favorite data from over the years onto a new page for your easy access.
Check out our data highlights page at www.anatomic.com/datahighlights
#CompleteTheCircuit #NotYourAverageNeuron
Check out our data highlights page at www.anatomic.com/datahighlights
#CompleteTheCircuit #NotYourAverageNeuron
Harnessing a more physiological in vitro model for CIPN! Dr. Nanna Elman Andersen’s Ph.D. thesis explores chemotherapy-induced neurotoxicity using hiPSC-derived Schwann cells & sensory neurons, studying paclitaxel, vincristine & bortezomib. Read more: portal.findresearcher.sdu.dk/en/publicati...
Mechanisms of chemotherapy neurotoxicity in iPSC-derived schwann cells and sensory neurons
portal.findresearcher.sdu.dk
March 11, 2025 at 2:12 PM
Harnessing a more physiological in vitro model for CIPN! Dr. Nanna Elman Andersen’s Ph.D. thesis explores chemotherapy-induced neurotoxicity using hiPSC-derived Schwann cells & sensory neurons, studying paclitaxel, vincristine & bortezomib. Read more: portal.findresearcher.sdu.dk/en/publicati...
Science is serious stuff, but sometimes it can’t help but make you smile.
Especially when it smiles first 😁
Especially when it smiles first 😁
March 7, 2025 at 1:07 PM
Science is serious stuff, but sometimes it can’t help but make you smile.
Especially when it smiles first 😁
Especially when it smiles first 😁
🧒🏻👧🏽👦🏼👩🏽🦱Multiple donors. Same process. Sensory neurons derived from hiPSC lines (both healthy and diseased) express key ion channel targets for pain - NaV1.7, NaV1.8, and TRPV1.
#NotYourAverageNeuron #CompleteTheCircuit #DiseaseModeling #PainResearch
#NotYourAverageNeuron #CompleteTheCircuit #DiseaseModeling #PainResearch
March 4, 2025 at 3:02 PM
🧒🏻👧🏽👦🏼👩🏽🦱Multiple donors. Same process. Sensory neurons derived from hiPSC lines (both healthy and diseased) express key ion channel targets for pain - NaV1.7, NaV1.8, and TRPV1.
#NotYourAverageNeuron #CompleteTheCircuit #DiseaseModeling #PainResearch
#NotYourAverageNeuron #CompleteTheCircuit #DiseaseModeling #PainResearch
🚨 New Insights into Chronic Pain 🚨
Reduced KCC2 expression in the dorsal horn links to chronic pain and opioid use. KCC2 regulates chloride gradients for inhibition, and its dysfunction drives neuropathic pain. Findings support therapies targeting KCC2.
Read more: www.biorxiv.org/content/10.1...
Reduced KCC2 expression in the dorsal horn links to chronic pain and opioid use. KCC2 regulates chloride gradients for inhibition, and its dysfunction drives neuropathic pain. Findings support therapies targeting KCC2.
Read more: www.biorxiv.org/content/10.1...
Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use
Loss of GABAergic and glycinergic inhibitory efficacy in the spinal dorsal horn is associated with neuropathic pain and opioid-induced hyperalgesia in rodent models. Downregulation of the KCC2 chlorid...
www.biorxiv.org
February 28, 2025 at 1:54 PM
🚨 New Insights into Chronic Pain 🚨
Reduced KCC2 expression in the dorsal horn links to chronic pain and opioid use. KCC2 regulates chloride gradients for inhibition, and its dysfunction drives neuropathic pain. Findings support therapies targeting KCC2.
Read more: www.biorxiv.org/content/10.1...
Reduced KCC2 expression in the dorsal horn links to chronic pain and opioid use. KCC2 regulates chloride gradients for inhibition, and its dysfunction drives neuropathic pain. Findings support therapies targeting KCC2.
Read more: www.biorxiv.org/content/10.1...
💡 Paclitaxel, first FDA-approved in 1992 for ovarian cancer, is linked to chemotherapy-induced peripheral neuropathy (CIPN). Imaging shows dose-dependent cytotoxicity in sensory neurons & Schwann cell precursors, with co-cultures altering responses.
#CompleteTheCircuit #CIPN #PainResearch
#CompleteTheCircuit #CIPN #PainResearch
February 25, 2025 at 3:19 PM
💡 Paclitaxel, first FDA-approved in 1992 for ovarian cancer, is linked to chemotherapy-induced peripheral neuropathy (CIPN). Imaging shows dose-dependent cytotoxicity in sensory neurons & Schwann cell precursors, with co-cultures altering responses.
#CompleteTheCircuit #CIPN #PainResearch
#CompleteTheCircuit #CIPN #PainResearch
🔎How do you “spot” a melanocyte? You look with your naked eye!
With RealMELO, Anatomic is going MACROSCOPIC! If your drug screen readout is pigmentation, the effects will be obvious in as little as 7 days post-thaw!
#CompleteTheCircuit #Vitiligo #Melanoma #Cosmetics
With RealMELO, Anatomic is going MACROSCOPIC! If your drug screen readout is pigmentation, the effects will be obvious in as little as 7 days post-thaw!
#CompleteTheCircuit #Vitiligo #Melanoma #Cosmetics
February 21, 2025 at 1:34 PM
🔎How do you “spot” a melanocyte? You look with your naked eye!
With RealMELO, Anatomic is going MACROSCOPIC! If your drug screen readout is pigmentation, the effects will be obvious in as little as 7 days post-thaw!
#CompleteTheCircuit #Vitiligo #Melanoma #Cosmetics
With RealMELO, Anatomic is going MACROSCOPIC! If your drug screen readout is pigmentation, the effects will be obvious in as little as 7 days post-thaw!
#CompleteTheCircuit #Vitiligo #Melanoma #Cosmetics
📰RealDRG iPSC-derived nociceptors power a novel axonal electrophysiology platform! Using MaxWell Biosystems HD-MEAs + PDMS microstructures, this system aids nociceptor distinction & drug screening for neuropathic pain
🔗 Read more: www.biorxiv.org/content/10.1...
#Pain #TRPV1
🔗 Read more: www.biorxiv.org/content/10.1...
#Pain #TRPV1
An in vitro platform for characterizing axonal electrophysiology of individual human iPSC-derived nociceptors
Current treatments against severe forms of neuropathic pain demonstrate insufficient efficacy or lead to unwanted side effects as they fail to specifically target the affected nociceptors - a speciali...
www.biorxiv.org
February 19, 2025 at 7:35 PM
📰RealDRG iPSC-derived nociceptors power a novel axonal electrophysiology platform! Using MaxWell Biosystems HD-MEAs + PDMS microstructures, this system aids nociceptor distinction & drug screening for neuropathic pain
🔗 Read more: www.biorxiv.org/content/10.1...
#Pain #TRPV1
🔗 Read more: www.biorxiv.org/content/10.1...
#Pain #TRPV1
Sensory neurons and Schwann cells are better together❣️
Whether you are single or have date night plans, this is a scientific love story that you can study this Valentine’s day.
#CompleteTheCircuit #NotYourAverageNeuron #PainResearch #CoCultures #CMT
Whether you are single or have date night plans, this is a scientific love story that you can study this Valentine’s day.
#CompleteTheCircuit #NotYourAverageNeuron #PainResearch #CoCultures #CMT
February 14, 2025 at 3:02 PM
Sensory neurons and Schwann cells are better together❣️
Whether you are single or have date night plans, this is a scientific love story that you can study this Valentine’s day.
#CompleteTheCircuit #NotYourAverageNeuron #PainResearch #CoCultures #CMT
Whether you are single or have date night plans, this is a scientific love story that you can study this Valentine’s day.
#CompleteTheCircuit #NotYourAverageNeuron #PainResearch #CoCultures #CMT
🔬👩🔬Twitch isn’t only for gamers. See motor neuron-induced myofiber contraction in our neuromuscular junction (NMJ) assay using Anatomic’s new RealMOTO hiPSC-derived motor neurons! Industry-leading directed differentiation speed resulting in industry leading purity!
#ALS #CMT #Microfluidics
#ALS #CMT #Microfluidics
February 11, 2025 at 3:35 PM
🔬👩🔬Twitch isn’t only for gamers. See motor neuron-induced myofiber contraction in our neuromuscular junction (NMJ) assay using Anatomic’s new RealMOTO hiPSC-derived motor neurons! Industry-leading directed differentiation speed resulting in industry leading purity!
#ALS #CMT #Microfluidics
#ALS #CMT #Microfluidics
CIPN is a major challenge in oncology, often limiting treatment.
Using RealDRG™ hiPSC sensory neurons, we tested CIPN-related compounds and found that DSRM-3716, a SARM1 NADase inhibitor, preserves axonal density after bortezomib treatment. More studies underway!
#StemCells #CIPN #Pain
Using RealDRG™ hiPSC sensory neurons, we tested CIPN-related compounds and found that DSRM-3716, a SARM1 NADase inhibitor, preserves axonal density after bortezomib treatment. More studies underway!
#StemCells #CIPN #Pain
February 7, 2025 at 2:10 PM
CIPN is a major challenge in oncology, often limiting treatment.
Using RealDRG™ hiPSC sensory neurons, we tested CIPN-related compounds and found that DSRM-3716, a SARM1 NADase inhibitor, preserves axonal density after bortezomib treatment. More studies underway!
#StemCells #CIPN #Pain
Using RealDRG™ hiPSC sensory neurons, we tested CIPN-related compounds and found that DSRM-3716, a SARM1 NADase inhibitor, preserves axonal density after bortezomib treatment. More studies underway!
#StemCells #CIPN #Pain
Motor neurons 🤝 Schwann cell precursors
Adding SCPs enhances ALS models by increasing physiological relevance. As co-cultures mature, SCPs align with axons—the first step of myelination!
Learn more: support@anatomic.com
#CompleteTheCircuit #NotYourAverageNeuron
Adding SCPs enhances ALS models by increasing physiological relevance. As co-cultures mature, SCPs align with axons—the first step of myelination!
Learn more: support@anatomic.com
#CompleteTheCircuit #NotYourAverageNeuron
February 4, 2025 at 3:30 PM
Motor neurons 🤝 Schwann cell precursors
Adding SCPs enhances ALS models by increasing physiological relevance. As co-cultures mature, SCPs align with axons—the first step of myelination!
Learn more: support@anatomic.com
#CompleteTheCircuit #NotYourAverageNeuron
Adding SCPs enhances ALS models by increasing physiological relevance. As co-cultures mature, SCPs align with axons—the first step of myelination!
Learn more: support@anatomic.com
#CompleteTheCircuit #NotYourAverageNeuron
#SLAS2025 ✅ Kicking off the year with exciting progress!
We shared our latest work on Schwann cell integration into our CIPN sensory neuron model, along with advancements in other cell types. Great discussions, collaborations, and insights—let’s keep the momentum going!
#CompleteTheCircuit
We shared our latest work on Schwann cell integration into our CIPN sensory neuron model, along with advancements in other cell types. Great discussions, collaborations, and insights—let’s keep the momentum going!
#CompleteTheCircuit
February 3, 2025 at 3:49 PM
#SLAS2025 ✅ Kicking off the year with exciting progress!
We shared our latest work on Schwann cell integration into our CIPN sensory neuron model, along with advancements in other cell types. Great discussions, collaborations, and insights—let’s keep the momentum going!
#CompleteTheCircuit
We shared our latest work on Schwann cell integration into our CIPN sensory neuron model, along with advancements in other cell types. Great discussions, collaborations, and insights—let’s keep the momentum going!
#CompleteTheCircuit