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RayaVaiana

@rayaudld.bsky.social

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Georg Hanisch📎

@georghanisch.bsky.social

Offener Brief gegen eine wissenschaftsfeindliche Regierung mit der FPÖ von aktuell uber 1400 Unterzeichner:innen aus der Wissenschaft, es werden laufend mehr.
#Wissenschaftler:innenfürDemokratie
Ganzer Brief:
cryptpad.fr/pad/#/2/pad/...

https://cryptpad.fr/pad/#/2/pad/view/KKsa9BBTZJi66W372ZaHHRXFjolUgWl34tFXy9yIgek/embed/

February 6, 2025 at 5:49 PM

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Eric Topol

@erictopol.bsky.social

The heightened risk of #LongCovid (PASC) from reinfections or lack of vaccination among a cohort of essential workers
www.thelancet.com/journals/lan...

January 8, 2025 at 3:34 PM

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Ralf Wittenbrink

@ralfwittenbrink.bsky.social

Pathophysiologische Schlüsselrolle der Skelettmuskelstörung bei Post-COVID und Myalgischer Enzephalomyelitis/Chronischem Erschöpfungssyndrom (ME/CFS)

„Eine mitochondriale Dysfunktion ist eine seit langem vertretene Annahme zur Erklärung der Kardinalsymptome von ME/CFS. 🧵

Several mechanisms triggered by an infection can result in circulatory disturbance and hypoperfusion of muscles including autoantibodies [41], inflammation [22], sympathetic overactivity [10], endothelial dysfunction [42], impaired red blood cell deformability [43] and diminished preload [10]. Upon exertion, hypoperfusion of skeletal muscles leads to rise in protons, intracellular sodium and calcium [12], muscle necrosis [9], mitochondrial damage and enhanced production of reactive oxygens [13, 22]. In ME/CFS, the activation of the sodium pump (Na+/K+-ATPase) upon exertion may be diminished due to low ATP and dysfunctional ß2AdR and CGRP. At a certain level of intracellular sodium, the sodium-calcium-exchanger NCX changes its transport mode from calcium export to calcium import causing calcium overload that causes mitochondrial and myocyte damage. As a result, low ATP and ROS production further impair the sodium pump. ROS also impairs vascular function and perfusion. A vicious circle arises. ß2AdR: ß2-adrenergic receptor; CGRP: calcitonin-gene–related peptide; ROS: reactive oxygen species. Biorender was used to create the figure.

December 29, 2024 at 4:19 PM

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Spatz 🐦

@ulmerspatz.bsky.social

»Schäden an der Skelettmuskulatur und an den Mitochondrien sind nun endlich nachgewiesen und können Belastungsintoleranz und PEM erklären. «
#MECFS #PCS #LongCovid
onlinelibrary.wiley.com/doi/10.1002/...