Rasmus Krogh Norrild
@rasmusnorrild.bsky.social
Postdoc with Alexander Büll at DTU. Interested in all things protein, biochemistry, and biophysics.
Reposted by Rasmus Krogh Norrild
Probing the energy landscape of α-Synuclein amyloid fibril formation by systematic K-to-Q mutagenesis https://www.biorxiv.org/content/10.1101/2025.11.01.685997v1
November 3, 2025 at 10:48 PM
Probing the energy landscape of α-Synuclein amyloid fibril formation by systematic K-to-Q mutagenesis https://www.biorxiv.org/content/10.1101/2025.11.01.685997v1
Reposted by Rasmus Krogh Norrild
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!
rdcu.be/eq975
rdcu.be/eq975
Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq
Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...
rdcu.be
June 17, 2025 at 3:26 AM
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!
rdcu.be/eq975
rdcu.be/eq975
Reposted by Rasmus Krogh Norrild
In collaboration with the @lindorfflarsen.bsky.social group we release our map of degrons in >5,000 human cytosolic proteins with >99% coverage. A machine learning model trained on the data identifies missense variants forming degrons in exposed & disordered regions. Work led by @vvouts.bsky.social.
A complete map of human cytosolic degrons and their relevance for disease
Degrons are short protein segments that target proteins for degradation via the ubiquitin-proteasome system and thus ensure timely removal of signaling proteins and clearance of misfolded proteins fro...
www.biorxiv.org
May 15, 2025 at 11:56 AM
In collaboration with the @lindorfflarsen.bsky.social group we release our map of degrons in >5,000 human cytosolic proteins with >99% coverage. A machine learning model trained on the data identifies missense variants forming degrons in exposed & disordered regions. Work led by @vvouts.bsky.social.
Reposted by Rasmus Krogh Norrild
mRNA display continues to astound. Fantastic collaboration with Alex Buell, led by the peerless @rasmusnorrild.bsky.social. ~100,000 peptides and their propensity to join the phase separation of a model disordered protein. doi.org/10.1101/2024...
Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins
The formation of biomolecular condensates is involved in compartmentalisation, regulation, and signalling across most living organisms. Condensation can be driven by phase separation of proteins, and ...
doi.org
January 13, 2025 at 9:33 AM
mRNA display continues to astound. Fantastic collaboration with Alex Buell, led by the peerless @rasmusnorrild.bsky.social. ~100,000 peptides and their propensity to join the phase separation of a model disordered protein. doi.org/10.1101/2024...
Reposted by Rasmus Krogh Norrild
We are finally ready to share the preprint version about our use of mRNA-display to study what makes disordered proteins form condensates, at the proteome-scale!
Check it out here:
Check it out here:
Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins https://www.biorxiv.org/content/10.1101/2024.12.21.629870v1
December 21, 2024 at 4:10 PM
We are finally ready to share the preprint version about our use of mRNA-display to study what makes disordered proteins form condensates, at the proteome-scale!
Check it out here:
Check it out here:
Reposted by Rasmus Krogh Norrild
Thermodynamic Stability Modulates Chaperone-Mediated Disaggregation of α-Synuclein Fibrils https://www.biorxiv.org/content/10.1101/2024.12.19.629136v1
December 21, 2024 at 1:48 PM
Thermodynamic Stability Modulates Chaperone-Mediated Disaggregation of α-Synuclein Fibrils https://www.biorxiv.org/content/10.1101/2024.12.19.629136v1
Reposted by Rasmus Krogh Norrild
Check out @rasmusnorrild.bsky.social's work with Alex Buell and Joe Rogers developing and using Condensate Partitioning by mRNA-Display to probe phase separation of ~100.000 sequences, and @sobuelow.bsky.social's simulations to support and analyse the experiments
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 21, 2024 at 4:32 PM
Check out @rasmusnorrild.bsky.social's work with Alex Buell and Joe Rogers developing and using Condensate Partitioning by mRNA-Display to probe phase separation of ~100.000 sequences, and @sobuelow.bsky.social's simulations to support and analyse the experiments
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
We are finally ready to share the preprint version about our use of mRNA-display to study what makes disordered proteins form condensates, at the proteome-scale!
Check it out here:
Check it out here:
Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins https://www.biorxiv.org/content/10.1101/2024.12.21.629870v1
December 21, 2024 at 4:10 PM
We are finally ready to share the preprint version about our use of mRNA-display to study what makes disordered proteins form condensates, at the proteome-scale!
Check it out here:
Check it out here:
Reposted by Rasmus Krogh Norrild
Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins https://www.biorxiv.org/content/10.1101/2024.12.21.629870v1
December 21, 2024 at 3:50 PM
Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins https://www.biorxiv.org/content/10.1101/2024.12.21.629870v1