Ryan Knight
@r-knight.bsky.social
Doctoral Student - Wellcome-Wolfson Institute for Experimental Medicine.
PRR Signalling - Innate Immunity
(views own)
PRR Signalling - Innate Immunity
(views own)
Reposted by Ryan Knight
Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW
shorturl.at/8lWxW
Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...
shorturl.at
May 1, 2025 at 11:17 PM
Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW
shorturl.at/8lWxW
Reposted by Ryan Knight
The NCI grant supporting the Columbia comprehensive cancer center was terminated. Tell me how terminating support for cancer research helps the economy.
taggs.hhs.gov/Content/Data...
taggs.hhs.gov/Content/Data...
March 18, 2025 at 10:28 PM
The NCI grant supporting the Columbia comprehensive cancer center was terminated. Tell me how terminating support for cancer research helps the economy.
taggs.hhs.gov/Content/Data...
taggs.hhs.gov/Content/Data...
Reposted by Ryan Knight
The NIH announced it will slash billions of dollars of support to universities and research centers.
This is one of the biggest attacks on science we have ever seen. It could dismantle the biomedical research system, shut down clinical trials, and halt development of treatments.
This is one of the biggest attacks on science we have ever seen. It could dismantle the biomedical research system, shut down clinical trials, and halt development of treatments.
February 8, 2025 at 3:02 AM
The NIH announced it will slash billions of dollars of support to universities and research centers.
This is one of the biggest attacks on science we have ever seen. It could dismantle the biomedical research system, shut down clinical trials, and halt development of treatments.
This is one of the biggest attacks on science we have ever seen. It could dismantle the biomedical research system, shut down clinical trials, and halt development of treatments.
Reposted by Ryan Knight
Applications for undergraduate summer studentships @wwiem-qub.bsky.social are now open. We would love to host enthusiastic students from anywhere in the world in Belfast! 👨🔬👩🔬🧪💊🌎 Details: www.qub.ac.uk/research-cen...
Summer Student Programme | Wellcome-Wolfson Institute For Experimental Medicine | Queen's University Belfast
www.qub.ac.uk
February 3, 2025 at 4:57 PM
Applications for undergraduate summer studentships @wwiem-qub.bsky.social are now open. We would love to host enthusiastic students from anywhere in the world in Belfast! 👨🔬👩🔬🧪💊🌎 Details: www.qub.ac.uk/research-cen...