Qi Chen
@qichen-lab.bsky.social
Associate Professor, University of Utah | sperm RNA-mediated epigenetic inheritance, embryo development, small RNAs, RNA modifications & diseases | http://qichen-lab.info
Pinned
Qi Chen
@qichen-lab.bsky.social
· Aug 20
Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation in @natcellbio.nature.com where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA
rdcu.be/eBwPJ
rdcu.be/eBwPJ
Reposted by Qi Chen
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 28, 2025 at 4:02 PM
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
After developing PANDORA-seq to reveal hidden small RNAs (e.g., tsRNA, rsRNA) and SPORTS to annotate them, we now expand our toolchain with Tong Zhou lab: introducing FUSION, a tool that robustly interprets small RNA changes even in small or 1-on-1 datasets.
academic.oup.com/bioinformati...
academic.oup.com/bioinformati...
FUSION: a family-level integration approach for robust differential analysis of small non-coding RNAs
AbstractMotivation. Beyond well-studied microRNAs, noncanonical small non-coding RNAs (sncRNAs) derived from longer parental templates such as tRNAs, rRNAs
academic.oup.com
September 18, 2025 at 9:05 PM
After developing PANDORA-seq to reveal hidden small RNAs (e.g., tsRNA, rsRNA) and SPORTS to annotate them, we now expand our toolchain with Tong Zhou lab: introducing FUSION, a tool that robustly interprets small RNA changes even in small or 1-on-1 datasets.
academic.oup.com/bioinformati...
academic.oup.com/bioinformati...
Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation in @natcellbio.nature.com where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA
rdcu.be/eBwPJ
rdcu.be/eBwPJ
August 20, 2025 at 10:29 AM
Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation in @natcellbio.nature.com where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA
rdcu.be/eBwPJ
rdcu.be/eBwPJ
Reposted by Qi Chen
Our 🌷 May 🌷 issue is online with a broad range of article topics and formats!
In their Opinion article (on the cover, too!), @qichen-lab.bsky.social and colleagues describe the interactions between small ncRNAs and Toll-like receptors.
Find the issue here: www.cell.com/trends/bioch...
In their Opinion article (on the cover, too!), @qichen-lab.bsky.social and colleagues describe the interactions between small ncRNAs and Toll-like receptors.
Find the issue here: www.cell.com/trends/bioch...
May 1, 2025 at 8:54 PM
Our 🌷 May 🌷 issue is online with a broad range of article topics and formats!
In their Opinion article (on the cover, too!), @qichen-lab.bsky.social and colleagues describe the interactions between small ncRNAs and Toll-like receptors.
Find the issue here: www.cell.com/trends/bioch...
In their Opinion article (on the cover, too!), @qichen-lab.bsky.social and colleagues describe the interactions between small ncRNAs and Toll-like receptors.
Find the issue here: www.cell.com/trends/bioch...
Very glad to see our Sequential Activation Hypothesis highlighted on the cover @cp-trendsbiochem.bsky.social , linking small RNA-TLR interactions to autoimmune disease mechanisms.
May 1, 2025 at 5:21 PM
Very glad to see our Sequential Activation Hypothesis highlighted on the cover @cp-trendsbiochem.bsky.social , linking small RNA-TLR interactions to autoimmune disease mechanisms.
Reposted by Qi Chen
#NewNProt for #genomewide characterization of a diverse set of #smallnoncodingRNAs in cells and tissues
Optimized identification and characterization of small RNAs with PANDORA-seq - Nature Protocols
This Protocol describes optimized procedures for purification and sequencing of small noncoding RNAs from a variety of samples to characterize these diverse RNA species and map them to the parental RNAs from which they originate.
bit.ly
April 8, 2025 at 10:48 AM
#NewNProt for #genomewide characterization of a diverse set of #smallnoncodingRNAs in cells and tissues
We put together a step-by-step protocols for PANDORA-seq, now available in Nature Protocols @natprot.bsky.social , including the sample preparation for sperm, sperm heads; and the analyzing software SPORTS optimized for various types of small RNAs including tsRNAs, rsRNAs, and miRNAs. rdcu.be/egk1Z
April 4, 2025 at 6:10 AM
We put together a step-by-step protocols for PANDORA-seq, now available in Nature Protocols @natprot.bsky.social , including the sample preparation for sperm, sperm heads; and the analyzing software SPORTS optimized for various types of small RNAs including tsRNAs, rsRNAs, and miRNAs. rdcu.be/egk1Z
How can abnormal small RNA biogenesis spark autoimmune disease? Our opinion @cp-trendsbiochem.bsky.social discuss a novel two-stage activation hypothesis that may explain why autoimmunity hits women harder, via small RNA-TLR7/8 interactions & augmented by autoantibodies.
www.cell.com/trends/bioch...
www.cell.com/trends/bioch...
February 16, 2025 at 12:39 AM
How can abnormal small RNA biogenesis spark autoimmune disease? Our opinion @cp-trendsbiochem.bsky.social discuss a novel two-stage activation hypothesis that may explain why autoimmunity hits women harder, via small RNA-TLR7/8 interactions & augmented by autoantibodies.
www.cell.com/trends/bioch...
www.cell.com/trends/bioch...
Reposted by Qi Chen
December 5, 2024 at 9:23 PM
