Sachin Pundhir
@pundhir.bsky.social
Senior Scientist - Computational biology @UCPH_BRIC, @Rigshospitalet
Interest: regulatory genomics in stem cell differentiation and cancer using #DataScience #ML
https://scholar.google.com/citations?hl=en&user=KNHvdX8AAAAJ&view_op=list_works&sortby=pubda
Interest: regulatory genomics in stem cell differentiation and cancer using #DataScience #ML
https://scholar.google.com/citations?hl=en&user=KNHvdX8AAAAJ&view_op=list_works&sortby=pubda
Reposted by Sachin Pundhir
he partnered with The Happy Slate to create a 3-minute animation explaining this work! please check it out :)
youtu.be/KFPZ9Rhjs4Y
youtu.be/KFPZ9Rhjs4Y
PADIT-seq reveals multiple overlapping binding sites determined transcription factor occupancy
YouTube video by Shubham Khetan
youtu.be
September 3, 2025 at 3:34 PM
he partnered with The Happy Slate to create a 3-minute animation explaining this work! please check it out :)
youtu.be/KFPZ9Rhjs4Y
youtu.be/KFPZ9Rhjs4Y
Reposted by Sachin Pundhir
This preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10....
@imperiallifesci.bsky.social
@imperiallifesci.bsky.social
August 20, 2025 at 1:23 PM
This preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10....
@imperiallifesci.bsky.social
@imperiallifesci.bsky.social
Reposted by Sachin Pundhir
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
H3K4me3 amplifies transcription at intergenic active regulatory elements
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
August 20, 2025 at 1:29 AM
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...