Thanks!

Thanks Sandra😍

Thanks Roman!

Thanks Gideon!

Thanks Floris!

Thanks Pablo!

As the Science editor @dijiang319.bsky.social nicely worded: “This reveals a role for RNA transcripts in restoring genome architecture and maintaining its integrity and function”. Big thanks to all Knipscheer lab members, @hubrechtinstitute.bsky.social, and @oncodeinstitute.bsky.social (4/4)

Inhibition of this mechanism causes global G4 and R-loop accumulation, leading to transcription dysregulation, replication stress, and genome instability. Thanks to cells from @joost84.bsky.social from the Tijsterman lab and amazing scEdUseq by @jervdberg.bsky.social from the Oudenaarden lab (3/4)

We found G4s are recognized as DNA lesions leading to homology-directed invasion of RNA opposite the G4 to form a G-loop structure. This G-loop initiates G4 unwinding by DHX36 and FANCJ. Subsequent nucleolytic incision followed by renewal of the RNA-containing strand drive G-loop disassembly (2/4)

Hi Erik, i am a group leader at the Hubrecht Institute and I would like to be added to the feed. Here is the link to my lab website: www.hubrecht.eu/research-gro...

I totally agree Helen, trying to solve a problem actually makes it worse.

@puckknipscheer.bsky.social, @luijsterburglab.bsky.social, @marcelvanvugt.bsky.social, @sylvie-noordermeer.bsky.social, @titiasixma.bsky.social, @marcelvanvugt.bsky.social, @marteijnlab.bsky.social