Prajwal Bharadwaj
@prajwalvb.bsky.social
PhD @ University of Liverpool studying Plasmids + Pathogens + Evolution + AMR
prajwalbharadwaj.com
prajwalbharadwaj.com
Reposted by Prajwal Bharadwaj
A must-read, must-share piece - clearly deconstructing the shoddy science of the Geiers (who are inexplicably in charge of studies at HHS).
Consider this an early warning for what lies ahead. 🛟🩺🧪
www.nytimes.com/interactive/...
Consider this an early warning for what lies ahead. 🛟🩺🧪
www.nytimes.com/interactive/...
Opinion | The Playbook Used to ‘Prove’ Vaccines Cause Autism (Gift Article)
Data can easily be manipulated to show a causation that doesn’t exist.
www.nytimes.com
August 19, 2025 at 12:40 PM
A must-read, must-share piece - clearly deconstructing the shoddy science of the Geiers (who are inexplicably in charge of studies at HHS).
Consider this an early warning for what lies ahead. 🛟🩺🧪
www.nytimes.com/interactive/...
Consider this an early warning for what lies ahead. 🛟🩺🧪
www.nytimes.com/interactive/...
Reposted by Prajwal Bharadwaj
If you ever find yourself needing evidence for ‘Plasmids are just as common in microbes without resistance genes,’ we’ve got you covered! Check our new paper, out today:
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
Plasmid prevalence is independent of antibiotic resistance in environmental Enterobacteriaceae
The rapid rise of antibiotic-resistant pathogens poses a critical threat to the treatment of infectious diseases. While the spread of antibiotic resistance genes (ARGs) via plasmid conjugation has bee...
www.microbiologyresearch.org
August 12, 2025 at 5:14 PM
If you ever find yourself needing evidence for ‘Plasmids are just as common in microbes without resistance genes,’ we’ve got you covered! Check our new paper, out today:
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
Reposted by Prajwal Bharadwaj
New paper out! 🔈🔈📣📣
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.
Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.
Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation
Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...
www.biorxiv.org
August 13, 2025 at 6:26 AM
New paper out! 🔈🔈📣📣
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.
Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.
Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
Reposted by Prajwal Bharadwaj
Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.
August 12, 2025 at 12:47 PM
Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.
Reposted by Prajwal Bharadwaj
Delighted to have this review out with @jpjhall.bsky.social!
We discuss the risk of transmission of antimicrobial resistance in the hospital sink drain microbiome, highlight studies providing evidence of transfer, and consider strategies to mitigate these risks 🪠🦠
doi.org/10.1038/s442...
We discuss the risk of transmission of antimicrobial resistance in the hospital sink drain microbiome, highlight studies providing evidence of transfer, and consider strategies to mitigate these risks 🪠🦠
doi.org/10.1038/s442...
The hospital sink drain microbiome as a melting pot for AMR transmission to nosocomial pathogens - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - The hospital sink drain microbiome as a melting pot for AMR transmission to nosocomial pathogens
doi.org
July 30, 2025 at 8:14 AM
Delighted to have this review out with @jpjhall.bsky.social!
We discuss the risk of transmission of antimicrobial resistance in the hospital sink drain microbiome, highlight studies providing evidence of transfer, and consider strategies to mitigate these risks 🪠🦠
doi.org/10.1038/s442...
We discuss the risk of transmission of antimicrobial resistance in the hospital sink drain microbiome, highlight studies providing evidence of transfer, and consider strategies to mitigate these risks 🪠🦠
doi.org/10.1038/s442...
Reposted by Prajwal Bharadwaj
For anyone interested in early US history and its intersection with science and discovery, I highly recommend the book "The Scientist Turned Spy: Andre Michaux, Thomas Jefferson, and the Conspiracy of 1793" by Patrick Spero.
www.upress.virginia.edu/title/10032/
#history #science #botany
www.upress.virginia.edu/title/10032/
#history #science #botany
The Scientist Turned Spy
<b>The incredible story of an explorer caught up in international intrigue at the dawn of US history</b><br/><br/> André Michaux was the most accompli
www.upress.virginia.edu
July 16, 2025 at 5:16 PM
For anyone interested in early US history and its intersection with science and discovery, I highly recommend the book "The Scientist Turned Spy: Andre Michaux, Thomas Jefferson, and the Conspiracy of 1793" by Patrick Spero.
www.upress.virginia.edu/title/10032/
#history #science #botany
www.upress.virginia.edu/title/10032/
#history #science #botany
Reposted by Prajwal Bharadwaj
Curious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
doi.org
July 2, 2025 at 10:07 AM
Curious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
Reposted by Prajwal Bharadwaj
What determines who a phage can infect?
We tackled this question for temperate phages of Klebsiella — a bacterial pathogen — using a genome-wide association study (GWAS) and a massive protein testing effort.
👇 A thread!
We tackled this question for temperate phages of Klebsiella — a bacterial pathogen — using a genome-wide association study (GWAS) and a massive protein testing effort.
👇 A thread!
June 26, 2025 at 7:13 AM
What determines who a phage can infect?
We tackled this question for temperate phages of Klebsiella — a bacterial pathogen — using a genome-wide association study (GWAS) and a massive protein testing effort.
👇 A thread!
We tackled this question for temperate phages of Klebsiella — a bacterial pathogen — using a genome-wide association study (GWAS) and a massive protein testing effort.
👇 A thread!
Reposted by Prajwal Bharadwaj
🚨 Very excited to finally say… 🚨
The story of Noodlococcus - the contaminant that started ContamClub - is available to read 📖🍜🦠
Check it out ➡️ doi.org/10.1101/2025...
1/15 🧵
The story of Noodlococcus - the contaminant that started ContamClub - is available to read 📖🍜🦠
Check it out ➡️ doi.org/10.1101/2025...
1/15 🧵
June 2, 2025 at 8:00 AM
🚨 Very excited to finally say… 🚨
The story of Noodlococcus - the contaminant that started ContamClub - is available to read 📖🍜🦠
Check it out ➡️ doi.org/10.1101/2025...
1/15 🧵
The story of Noodlococcus - the contaminant that started ContamClub - is available to read 📖🍜🦠
Check it out ➡️ doi.org/10.1101/2025...
1/15 🧵
Reposted by Prajwal Bharadwaj
EMPSEB30 has come to an end, but we’re thrilled by the many enthusiastic volunteers eager to organize EMPSEB31. Next stop could be France 🇫🇷, Germany 🇩🇪, or Denmark 🇩🇰… we’ll see! Wishing all future organizers the best of luck!💫
June 9, 2025 at 3:00 PM
EMPSEB30 has come to an end, but we’re thrilled by the many enthusiastic volunteers eager to organize EMPSEB31. Next stop could be France 🇫🇷, Germany 🇩🇪, or Denmark 🇩🇰… we’ll see! Wishing all future organizers the best of luck!💫
Reposted by Prajwal Bharadwaj
Had a great time at @pintofscience.uk in Ship & Mitre, Liverpool last night 🦠 🍺 🧫 some really great talks! A particular well done to @prajwalvb.bsky.social, we’re all waiting patiently for you to release “Keeping up with the Chemotrophs” 😉
May 22, 2025 at 3:35 PM
Had a great time at @pintofscience.uk in Ship & Mitre, Liverpool last night 🦠 🍺 🧫 some really great talks! A particular well done to @prajwalvb.bsky.social, we’re all waiting patiently for you to release “Keeping up with the Chemotrophs” 😉
Reposted by Prajwal Bharadwaj
Prajwal Vishwanath Bharadwaj @prajwalvb.bsky.social started Session 1B off with a great talk on the host ranges of different plasmids in closely related Pseudomonas aeruginosa.
#EMPSEB30 #conference #phdstudent #evolution #plasmids
#EMPSEB30 #conference #phdstudent #evolution #plasmids
June 3, 2025 at 1:58 PM
Prajwal Vishwanath Bharadwaj @prajwalvb.bsky.social started Session 1B off with a great talk on the host ranges of different plasmids in closely related Pseudomonas aeruginosa.
#EMPSEB30 #conference #phdstudent #evolution #plasmids
#EMPSEB30 #conference #phdstudent #evolution #plasmids
Reposted by Prajwal Bharadwaj
🆕New in @plosbiology.bsky.social: we show compensatory mutations make plasmids play Rock-Paper-Scissors and turn conjugation into a weapon🛡️💫✂️🦠
w/Rosanna Wright, Jamie Wood, @mbottery.bsky.social, @kmudz.bsky.social, @scottishwormboy.bsky.social, Ellie Harrison & @brockhurstlab.bsky.social #MicroSky
w/Rosanna Wright, Jamie Wood, @mbottery.bsky.social, @kmudz.bsky.social, @scottishwormboy.bsky.social, Ellie Harrison & @brockhurstlab.bsky.social #MicroSky
A chromosomal mutation is superior to a plasmid-encoded mutation for plasmid fitness cost compensation
Plasmids spread important traits in microbiomes but impose fitness costs on their hosts. This study of the ecological consequences of plasmid-bacterial compensatory evolution reveals benefits to bacte...
journals.plos.org
December 3, 2024 at 9:45 AM
🆕New in @plosbiology.bsky.social: we show compensatory mutations make plasmids play Rock-Paper-Scissors and turn conjugation into a weapon🛡️💫✂️🦠
w/Rosanna Wright, Jamie Wood, @mbottery.bsky.social, @kmudz.bsky.social, @scottishwormboy.bsky.social, Ellie Harrison & @brockhurstlab.bsky.social #MicroSky
w/Rosanna Wright, Jamie Wood, @mbottery.bsky.social, @kmudz.bsky.social, @scottishwormboy.bsky.social, Ellie Harrison & @brockhurstlab.bsky.social #MicroSky
Reposted by Prajwal Bharadwaj
I just made a first release of TNA - new tool to compare 2 bacterial genomes. Is shamelessly inspired by ACT, but should be simpler to use. Drag-n-drop two genomes: it runs BLAST for you and then you can visualize. For Mac, Windows 11, Linux tna.readthedocs.io
TNA documentation — TNA 0.0.1 documentation
tna.readthedocs.io
November 29, 2024 at 11:38 AM
I just made a first release of TNA - new tool to compare 2 bacterial genomes. Is shamelessly inspired by ACT, but should be simpler to use. Drag-n-drop two genomes: it runs BLAST for you and then you can visualize. For Mac, Windows 11, Linux tna.readthedocs.io
Biotic brushwork
@contamclub.bsky.social
@contamclub.bsky.social
November 28, 2024 at 11:09 PM
Biotic brushwork
@contamclub.bsky.social
@contamclub.bsky.social
Going to be spending winter in the lab with a cosy pair of ContamSocks; and the first in-person sale from
@contamclub.bsky.social !
@contamclub.bsky.social !
November 22, 2024 at 12:10 PM
Going to be spending winter in the lab with a cosy pair of ContamSocks; and the first in-person sale from
@contamclub.bsky.social !
@contamclub.bsky.social !
Thrilled to have attended #MicroBio24. It was wonderful meeting everyone at the talks and poster. Getting the Poster Prize was the icing on the cake. Back to reality now after a fantastic conference!
April 12, 2024 at 10:33 AM
Thrilled to have attended #MicroBio24. It was wonderful meeting everyone at the talks and poster. Getting the Poster Prize was the icing on the cake. Back to reality now after a fantastic conference!
Reposted by Prajwal Bharadwaj
Many Congratulations to @prajwalvb.bsky.social for winning the Microbial Genomics Poster Prize at #Microbio24!!!
April 11, 2024 at 12:25 PM
Many Congratulations to @prajwalvb.bsky.social for winning the Microbial Genomics Poster Prize at #Microbio24!!!
Reposted by Prajwal Bharadwaj
This paper was really fun to write! Unpicking the subtle differences between dependencies, facilitation and cooperation in microbial communities, and why it matters.
With Elze Hesse (not here yet!)
With Elze Hesse (not here yet!)
Ecological dependencies and the illusion of cooperation in microbial communities
Ecological dependencies – where organisms rely on other organisms for survival – are a ubiquitous feature of life on earth. Multicellular hosts rely on symbionts to provide essential vitamins and amin...
www.microbiologyresearch.org
February 22, 2024 at 2:53 PM
This paper was really fun to write! Unpicking the subtle differences between dependencies, facilitation and cooperation in microbial communities, and why it matters.
With Elze Hesse (not here yet!)
With Elze Hesse (not here yet!)
Reposted by Prajwal Bharadwaj
First paper from the MultiDefence consortium reviewing what we know about multi-layered genome defences in bacteria. Supported by BBSRC sLoLa led by Edze Westra. Aleksei Agapov did a great job pulling it all together! www.sciencedirect.com/science/arti...
February 17, 2024 at 12:58 PM
First paper from the MultiDefence consortium reviewing what we know about multi-layered genome defences in bacteria. Supported by BBSRC sLoLa led by Edze Westra. Aleksei Agapov did a great job pulling it all together! www.sciencedirect.com/science/arti...
Reposted by Prajwal Bharadwaj
“P. aeruginosa cells can directly sense differences in concentration across the lengths of their bodies, even in the presence of strong temporal fluctuations” 👇🏼😳
Bacteria use spatial sensing to direct chemotaxis on surfaces https://www.biorxiv.org/content/10.1101/2024.02.13.580113v1
Bacteria use spatial sensing to direct chemotaxis on surfaces https://www.biorxiv.org/content/10.1101/2024.02.13.580113v1
Planktonic bacteria navigate chemical gradients using temporal sensing to detect changes in concentr
www.biorxiv.org
February 14, 2024 at 6:30 AM
“P. aeruginosa cells can directly sense differences in concentration across the lengths of their bodies, even in the presence of strong temporal fluctuations” 👇🏼😳