Olfactory impairment is a hallmark of early Alzheimers disease (AD), but the underlying mechanisms connecting sensory decline to genetic and environmental risk factors remain unclear. Our integrative ...

Abstract. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinson’s disease; howe

David Cohen: The Father of MEG traces the life and science of David Cohen, the physicist who launched the field of biomagnetism and introduced the world to the biomedical imaging technology now known ...

The Women’s Health Initiative has produced numerous influential findings

MRI acquisition and reconstruction research has transformed into a computation-driven field. As methods become more sophisticated, compute-heavy, and data-hungry, efforts to reproduce them become more...

The Basics. This is a full-time position. This is a hybrid position. We'll ask that you spend at least one day per week in the office on a regular basis. A few times per year, there will be a w...

Apolipoprotein E (APOE) genotype and nitric oxide synthase 2 (NOS2) expression are key genetic factors that influence bone health. While prior studies explored differences in bones by APOE genotype, the role of sex and NOS2 require further investigation. In this study, we acquired micro-CT scans of femurs and analyzed their characteristics in a cohort of mice with variation in age, sex, APOE genotype, and humanized NOS2 (HN) expression. Femurs were extracted from 57 mice and scanned using photon-counting micro-CT with two energy thresholds. Scan data was iteratively reconstructed and decomposed into water and calcium material maps. Trabecular and cortical femur features were computed from calcium maps of femurs using ImageJ’s BoneJ plugin. Statistical analyses of femur features were applied on the entire cohort of mice and on subgroups stratified by sex, APOE genotype, and HN status. Our image quality assessment found that the calcium map has higher contrast to noise ratio than both energy channels of the iterative reconstruction. Differences in bone volume fraction by APOE genotype were found in the whole group, but this result was not reproduced in subgroups stratified by sex or HN status. Analyses in the whole group and in stratified subgroups revealed that the interaction between sex and HN status was a significant predictor of femur features and that HN females tend to have low trabecular bone content. This study illustrates the benefits of photon-counting CT for femur imaging and shows meaningful effects of age, APOE genotype, sex, HN, and their interactions on bone health.

Exercise is a promising strategy for preventing or delaying Alzheimers disease (AD), yet its mechanisms remain unclear. We investigated how exercise influences brain structure, function, and behavior ...

Using magnetic resonance imaging on marathon runners, Ramos-Cabrer, Cabrera-Zubizarreta et al. report that the signal detected as a surrogate of myelin content is significantly reduced after exercise,...

Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo. Initially, it was primarily used to report calcium dynami…

Dimakou et al.’s review examines how spontaneous brain activity across species from C. elegans to humans encodes behaviorally relevant sensory, motor, metabolic, and interoceptive states. They hypothe...

The ability to physically partition the human brain at a spatial resolution comparable to neuroimaging methods enabled the development of a brain-wide atlas of mitochondrial content, specialization an...

Nvidia CEO Jensen Huang is expected to reveal details about Rubin, the chipmaker's next AI GPU, on Tuesday at the company's annual GTC conference.

A longitudinal aging study using fMRI in anesthetized mice suggests brain network changes like humans. Mostly, female mice show a de-differentiation of networks with increased connectivity of prefront...

Abrupt cuts by the Trump administration to the US National Institutes of Health threaten progress in medical research globally.

Ultrahig-resolution (UHR) pCASL imaging could be highly relevant in myriad animal models of disease and plasticity. We develop a setup enabling UHR pCASL using a cryogenic coil and report increases i...

The sensitivity of pseudo-continuous arterial spin labeling (PCASL) to off-resonance effects (ΔB0) is a major limitation at ultra-high field (≥7T). The aim of this study was to assess the effectivenes...