Pilar Andrade
@pilarandrade.bsky.social
She/her • PhD candidate at Baylor College of Medicine studying neuroinflammation and lysosomal dysfunction • Interested in all things glia • 🧪🇲🇽 #LatinxInSTEM #firstgen #BLM
lipofuscin autofluorescence keeps me up at night
February 5, 2025 at 12:50 AM
lipofuscin autofluorescence keeps me up at night
it’s so stupid that macbooks don’t have a regular usb port !!! what is this usb-c bs 😩
January 21, 2025 at 7:35 PM
it’s so stupid that macbooks don’t have a regular usb port !!! what is this usb-c bs 😩
Reposted by Pilar Andrade
Mice lacking microglia (Csf1r∆FIRE/∆FIRE) have normal
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience
Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...
www.nature.com
January 7, 2025 at 2:34 PM
Mice lacking microglia (Csf1r∆FIRE/∆FIRE) have normal
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
time flies in the confocal room, how is it already 8:51 PM on a Wednesday !!!!
December 5, 2024 at 2:52 AM
time flies in the confocal room, how is it already 8:51 PM on a Wednesday !!!!
i’m getting so much holiday anxiety on top of my regular everyday anxiety😵💫
November 26, 2024 at 6:33 AM
i’m getting so much holiday anxiety on top of my regular everyday anxiety😵💫
Reposted by Pilar Andrade
Reposted by Pilar Andrade
Hi #astrocyte lovers! We are organizing the third edition of #AstrocyteCafe online, with FREE monthly seminars starting from January 2025...and we are looking for speakers!
Speakers can be of any career stage: just send us an email with your topic to astrocytecafe@gmail.com 😍
Speakers can be of any career stage: just send us an email with your topic to astrocytecafe@gmail.com 😍
November 22, 2024 at 1:17 PM
Hi #astrocyte lovers! We are organizing the third edition of #AstrocyteCafe online, with FREE monthly seminars starting from January 2025...and we are looking for speakers!
Speakers can be of any career stage: just send us an email with your topic to astrocytecafe@gmail.com 😍
Speakers can be of any career stage: just send us an email with your topic to astrocytecafe@gmail.com 😍
Reposted by Pilar Andrade
Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease https://www.biorxiv.org/content/10.1101/2024.11.16.623962v1
Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease https://www.biorxiv.org/content/10.1101/2024.11.16.623962v1
There is growing evidence suggesting that the lysosome or lysosome dysfunction is associated with Al
www.biorxiv.org
November 18, 2024 at 11:16 PM
Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease https://www.biorxiv.org/content/10.1101/2024.11.16.623962v1
Reposted by Pilar Andrade
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion https://www.biorxiv.org/content/10.1101/2024.11.18.624173v1
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion https://www.biorxiv.org/content/10.1101/2024.11.18.624173v1
Abnormal lipid metabolism in Alzheimer's disease (AD) was first documented by Alois Alzheimer in his
www.biorxiv.org
November 19, 2024 at 12:08 PM
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion
do sunday scaries ever go away🥲
November 18, 2024 at 6:48 AM
do sunday scaries ever go away🥲
Reposted by Pilar Andrade
Microglia community, let’s start the discussion 🧠 follow the Microglia Starter Pack and ask @mancusorenzo.bsky.social to add your colleagues as they join Bluesky 🦋
go.bsky.app/DT3Cp4A
go.bsky.app/DT3Cp4A
November 17, 2024 at 12:52 PM
Microglia community, let’s start the discussion 🧠 follow the Microglia Starter Pack and ask @mancusorenzo.bsky.social to add your colleagues as they join Bluesky 🦋
go.bsky.app/DT3Cp4A
go.bsky.app/DT3Cp4A
Reposted by Pilar Andrade
Big findings for ApoE and neurodegeneration!!! Lipidated ApoE2 (lipApoE2) shows impaired binding to LDL receptors, preventing the LDLR recycling defects seen with lipApoE3/E4. This decreases cholesteryl ester (CE) uptake—lipids often linked to neurodegeneration. www.cell.com/cell/fulltex...
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
ApoE2 and ApoE Christchurch variants are defective in LDLR binding, thus reducing
the uptake of ApoE and associated lipid cargoes. LDLR-mediated internalization and
endolysosomal delivery of ApoE lipo...
www.cell.com
November 12, 2024 at 4:45 AM
Big findings for ApoE and neurodegeneration!!! Lipidated ApoE2 (lipApoE2) shows impaired binding to LDL receptors, preventing the LDLR recycling defects seen with lipApoE3/E4. This decreases cholesteryl ester (CE) uptake—lipids often linked to neurodegeneration. www.cell.com/cell/fulltex...