Pratik ‘Tik’ Patel MD
@pedsoncid.bsky.social
#PedsHemeOnc & #PedsID. Clinical care and innovation at the 🖇 of the two. #TravelHacker. Views=mine. 🩸🎗🧫🔬✈️
Reposted by Pratik ‘Tik’ Patel MD
🔥Out now! Our latest from @txidfellows.bsky.social on the use of social media in #TxID. doi.org/10.1111/tid.... @courtharrismd.bsky.social @rebeccakumar.bsky.social @germhuntermd.bsky.social @paulsaxmd.bsky.social @transplantid.bsky.social
Social Media Savvy, It's More Than Just the #Hashtags: How the Use of Social Media in Transplant Infectious Diseases Can Impact the Field and Patients
doi.org
December 18, 2024 at 7:53 PM
🔥Out now! Our latest from @txidfellows.bsky.social on the use of social media in #TxID. doi.org/10.1111/tid.... @courtharrismd.bsky.social @rebeccakumar.bsky.social @germhuntermd.bsky.social @paulsaxmd.bsky.social @transplantid.bsky.social
Reposted by Pratik ‘Tik’ Patel MD
🆕✨Systematic review and meta-analysis
Toxin results cannot rule in or rule out CDI, and the decision whether to treat symptomatic NAAT+/EIA− patients for CDI should be based on clinical presentation and not on the toxin result #idsky #EMIMCC #medsky
journals.asm.org/doi/10.1128/...
Toxin results cannot rule in or rule out CDI, and the decision whether to treat symptomatic NAAT+/EIA− patients for CDI should be based on clinical presentation and not on the toxin result #idsky #EMIMCC #medsky
journals.asm.org/doi/10.1128/...
Clinical significance of toxin EIA positivity in patients with suspected Clostridioides difficile infection: systematic review and meta-analysis | Journal of Clinical Microbiology
Clostridioides difficile infection (CDI) is a common cause of healthcare-associated infections and the leading
cause of antibiotic-associated diarrhea. However, the laboratory diagnosis of CDI,
primar...
journals.asm.org
December 13, 2024 at 4:25 PM
🆕✨Systematic review and meta-analysis
Toxin results cannot rule in or rule out CDI, and the decision whether to treat symptomatic NAAT+/EIA− patients for CDI should be based on clinical presentation and not on the toxin result #idsky #EMIMCC #medsky
journals.asm.org/doi/10.1128/...
Toxin results cannot rule in or rule out CDI, and the decision whether to treat symptomatic NAAT+/EIA− patients for CDI should be based on clinical presentation and not on the toxin result #idsky #EMIMCC #medsky
journals.asm.org/doi/10.1128/...
Reposted by Pratik ‘Tik’ Patel MD
Impact of clinician feedback reports on antibiotic use in children hospitalized with community-acquired pneumonia
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Impact of clinician feedback reports on antibiotic use in children hospitalized with community-acquired pneumonia
Feedback reports summarizing clinician performance are effective tools for improving antibiotic use in the ambulatory setting, but the effectiveness of feedback reports in the hospital setting is unknown.
buff.ly
December 12, 2024 at 1:41 PM
Impact of clinician feedback reports on antibiotic use in children hospitalized with community-acquired pneumonia
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
December 12, 2024 at 5:44 PM
But we aren’t using itraconazole for histo anymore these days right @fungaldoc.bsky.social?
Check out WUMG (WUSTL) latest research manuscript examining side effects of Itraconazole in the treatment of Histoplasmosis. Great project led by Dr Matthew Osborn and mentored by the amazing @fungaldoc.bsky.social 🚨🚨🚨🚨🚨🚨🚨🚨
Side effects associated with itraconazole therapy
AbstractBackground. Itraconazole is the treatment of choice for many fungal infections, including histoplasmosis. While the tolerability of itraconazole ha
academic.oup.com
December 11, 2024 at 6:17 PM
But we aren’t using itraconazole for histo anymore these days right @fungaldoc.bsky.social?
Reposted by Pratik ‘Tik’ Patel MD
#ASHKudos to Rachel Rau, Sumit Gupta, the whole AALL1731 study committee, all of our COG sites, and most importantly, our patients and families who made these results possible. So exciting to officially see these results on the big stage at #ASH24 (and presented by a great mentor too!)
December 8, 2024 at 10:39 PM
Reposted by Pratik ‘Tik’ Patel MD
I never tire of seeing these progressively improved pediatric ALL survival curves, which represent one of the most remarkable achievements in all of medicine.
Amazing to see even more improvement with bispecific antibody #immunotherapy presented in the #ASH24 Plenary session. #hematology #leukemia
Amazing to see even more improvement with bispecific antibody #immunotherapy presented in the #ASH24 Plenary session. #hematology #leukemia
December 8, 2024 at 10:16 PM
I never tire of seeing these progressively improved pediatric ALL survival curves, which represent one of the most remarkable achievements in all of medicine.
Amazing to see even more improvement with bispecific antibody #immunotherapy presented in the #ASH24 Plenary session. #hematology #leukemia
Amazing to see even more improvement with bispecific antibody #immunotherapy presented in the #ASH24 Plenary session. #hematology #leukemia
Reposted by Pratik ‘Tik’ Patel MD
December 6, 2024 at 4:58 PM
Reposted by Pratik ‘Tik’ Patel MD
Studies show more promising results for RSV drug nirsevimab
There were 24 cases of RSV infection through day 151 in the nirsevimab arm and 54 in the placebo arm.
www.cidrap.umn.edu/r...
There were 24 cases of RSV infection through day 151 in the nirsevimab arm and 54 in the placebo arm.
www.cidrap.umn.edu/r...
December 5, 2024 at 9:01 PM
Studies show more promising results for RSV drug nirsevimab
There were 24 cases of RSV infection through day 151 in the nirsevimab arm and 54 in the placebo arm.
www.cidrap.umn.edu/r...
There were 24 cases of RSV infection through day 151 in the nirsevimab arm and 54 in the placebo arm.
www.cidrap.umn.edu/r...
Facts.
One reason this is particularly true is kids can’t vote and the people who are supposed to vote on their behalf, don’t.
One reason this is particularly true is kids can’t vote and the people who are supposed to vote on their behalf, don’t.
Graph these by salary and you’ll get the same results. Pediatricians get paid less because our society doesn’t value children, and particularly sick disabled children. And as pediatricians we have accepted a system where we are devalued because we advocate for our patients instead of ourselves.
Percentage of available positions that filled in yesterday’s fellowship match.
December 6, 2024 at 12:36 PM
Facts.
One reason this is particularly true is kids can’t vote and the people who are supposed to vote on their behalf, don’t.
One reason this is particularly true is kids can’t vote and the people who are supposed to vote on their behalf, don’t.
Dang ~16% macrolide resistance for Mycoplasma in Ontario 🇨🇦 this year!
www.publichealthontario.ca/-/media/Docu...
www.publichealthontario.ca/-/media/Docu...
www.publichealthontario.ca
December 6, 2024 at 12:03 AM
Dang ~16% macrolide resistance for Mycoplasma in Ontario 🇨🇦 this year!
www.publichealthontario.ca/-/media/Docu...
www.publichealthontario.ca/-/media/Docu...
Reposted by Pratik ‘Tik’ Patel MD
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research.
A Place of Joy.
A Place of Joy.
December 3, 2024 at 2:10 PM
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
Bactericidal antibiotics release DNA that activates TLR9, while static antibiotics do not, and this excessive inflammation can blunt efficacy.
Fascinating study!
www.nature.com/articles/s41...
Fascinating study!
www.nature.com/articles/s41...
Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA - Nature Communications
The immunologic differences induced by bactericidal versus bacteriostatic antibiotics remain unclear. Gross et al. show that, in contrast to static antibiotics, cidal antibiotics may drive harmfu...
www.nature.com
December 2, 2024 at 3:14 PM
Bactericidal antibiotics release DNA that activates TLR9, while static antibiotics do not, and this excessive inflammation can blunt efficacy.
Fascinating study!
www.nature.com/articles/s41...
Fascinating study!
www.nature.com/articles/s41...
#IDSky, is there a good study that shows development of a MDR organism for a patient results in worse outcome?
Obviously would need to control for a lot of confounders but wondering if someone has attempted and somewhat succeeded.
Obviously would need to control for a lot of confounders but wondering if someone has attempted and somewhat succeeded.
November 27, 2024 at 1:41 AM
#IDSky, is there a good study that shows development of a MDR organism for a patient results in worse outcome?
Obviously would need to control for a lot of confounders but wondering if someone has attempted and somewhat succeeded.
Obviously would need to control for a lot of confounders but wondering if someone has attempted and somewhat succeeded.
Makes sense to me given neurologic injury and importance of hgb to likely recovery.
A liberal transfusion strategy compared with a restrictive strategy resulted in a lower rate of unfavorable neurological outcome among patients with acute brain injury.
ja.ma/3V5z1p9
ja.ma/3V5z1p9
November 25, 2024 at 1:09 PM
Makes sense to me given neurologic injury and importance of hgb to likely recovery.
Repurpose retool
This is super exciting. JAK1 inhibitor turns out to be a very effective treatment for TEN/SJS
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com
November 25, 2024 at 1:49 AM
Repurpose retool
‘Data support mRNA SARS-CoV-2 vaccination prior to, and reinitiation 3 to 4 months after’ CART/HCT
SARS-CoV-2 Vaccination in the First Year After HCT or #CARTcells - Results of #BMTCTN Prospective, Multicenter, Observational Study - Great collaboration with @joshhillmd.bsky.social & other investigators @cidjournal.bsky.social #vaccines #covid #bmtsm academic.oup.com/cid/article-...
academic.oup.com
November 22, 2024 at 5:02 PM
‘Data support mRNA SARS-CoV-2 vaccination prior to, and reinitiation 3 to 4 months after’ CART/HCT
Reposted by Pratik ‘Tik’ Patel MD
First #IDSky post!
For IC patient who had a CVL and developed polymicrobial (main bugs Pseudomonas and MSSA) native TV endocarditis, no indication for surgery, what would you use to treat and how long?
For IC patient who had a CVL and developed polymicrobial (main bugs Pseudomonas and MSSA) native TV endocarditis, no indication for surgery, what would you use to treat and how long?
November 21, 2024 at 4:16 PM
First #IDSky post!
For IC patient who had a CVL and developed polymicrobial (main bugs Pseudomonas and MSSA) native TV endocarditis, no indication for surgery, what would you use to treat and how long?
For IC patient who had a CVL and developed polymicrobial (main bugs Pseudomonas and MSSA) native TV endocarditis, no indication for surgery, what would you use to treat and how long?
Good review of chest imaging findings in immunocompromised patients!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Lung Nodules and Masses in non-HIV Immunocompromised Patients: A Clinical-Imaging Algorithmic Approach
The incidence of pulmonary nodules and masses in non-HIV immunocompromised patients has significantly increased due to advancements in hematopoietic s…
www.sciencedirect.com
November 22, 2024 at 12:45 PM
Good review of chest imaging findings in immunocompromised patients!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Host response predicts EOS in neonates 👀
Every year, >200K newborns die from sepsis.
Our team used machine learning to develop a set of genes that can predict neonatal sepsis risk using at birth blood samples.
www.thelancet.com/journals/ebi...
Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation
Despite appearing healthy at birth, neonates who later developed EOS already had distinct
whole blood gene expression changes at birth, which enabled the development of a 4-gene
predictive signature f...
www.thelancet.com
November 21, 2024 at 6:11 PM
Host response predicts EOS in neonates 👀
First #IDSky post!
For IC patient who had a CVL and developed polymicrobial (main bugs Pseudomonas and MSSA) native TV endocarditis, no indication for surgery, what would you use to treat and how long?
For IC patient who had a CVL and developed polymicrobial (main bugs Pseudomonas and MSSA) native TV endocarditis, no indication for surgery, what would you use to treat and how long?
November 21, 2024 at 4:16 PM
First #IDSky post!
For IC patient who had a CVL and developed polymicrobial (main bugs Pseudomonas and MSSA) native TV endocarditis, no indication for surgery, what would you use to treat and how long?
For IC patient who had a CVL and developed polymicrobial (main bugs Pseudomonas and MSSA) native TV endocarditis, no indication for surgery, what would you use to treat and how long?