Physical Biology of Developing Systems
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pbodslab.bsky.social
Physical Biology of Developing Systems
@pbodslab.bsky.social
We are located at @mcmasteruniversity.bsky.social McMaster University Biology/Physics departments studying early vertebrate embryo patterning with quantitative tools!
www.physicalbiology.ca
posts by M. Fethullah Simsek.
A picture snapped with phone camera today: a rare 'supernumerary' #rainbow over Hamilton with repeating colour sequence due to very small droplet sizes giving rise to interference patterns of #light by its #wave nature. 🧪
October 24, 2025 at 1:37 AM
Fascinating timelapses of #somite clock with cadherins from Kageyama Lab @dev-journal.bsky.social : journals.biologists.com/dev/article/...! A new player in clock and #fgf gradient cross-talk besides previously discovered Dusps linking both transcriptional and post-translationally. 🧪🔬 #devbio
October 20, 2025 at 5:29 PM
4/5 We can further observe ERK signal dynamics with live translocation reporter (yellow), which shuttles into the nuclei (cyan) from cytoplasm at the moment MEK inhibitory drug is being perfused into the imaging chamber (~24min).
October 2, 2025 at 2:27 AM
3/5 And as we perfuse 💉drugs 💊 and rinse them out in a pulsated fashion we can reconstitute somites in segmentation clock mutants (as I had done by hand in my postdoc @nature.com www.nature.com/articles/s41... ) now in a fully automated fashion, notice 5 boundaries forming at the end of movie 🐟:
October 2, 2025 at 2:27 AM
2/5🐟 embryos can stably be imaged on stage in sub-cellular resolution:
October 2, 2025 at 2:27 AM
1/5 Lab's first manuscript 🎉 is out @biorxivpreprint.bsky.social today! Beautifully, it is performed by a senior undergraduate thesis student, Mohammed! We developed a 3-D printed #zebrafish embryo imaging chamber 🔬and connected it to syringe pumps to be able to perfuse drugs in a timely fashion. 🧪
October 2, 2025 at 2:27 AM
Last day of #BSC2025 with fantastic developmental #biophysics talks: Ahmad Mahmood/ WisemanLab, Abby Gerhold from @mcgilluniversity.bsky.social, @pfrancois.bsky.social, @katwrog.bsky.social + keynote by Stas Shvartsman from @princetonmolbio.bsky.social #drosophila #zebrafish #celegans #plants.
May 23, 2025 at 9:58 PM
Great #zebrafish talk on tissue biomechanics going on at the @biophyscanada.bsky.social meeting @mcmasteruniversity.bsky.social given by @manningresearch.bsky.social #bsc2025
May 21, 2025 at 6:39 PM
1/2 We are hosting the Biophysical Society of #Canada annual meeting @mcmasteruniversity.bsky.social in May 20-23rd. This is a single stream event with sessions on #computational &theoretical #biophysics, new tools for biophysics, #development, mechanics of cells &tissues, #AI in biophysics,...🧪+
March 24, 2025 at 3:20 PM
Teaching developmental #biology is always a joy! Today, we covered how a 19 y/o undergrad student, Alfred Sturtevant, generated the first ever gene map; and published this as a solo author paper in Morgan's #embryology lab! #drosophila 🧪
March 6, 2025 at 2:24 AM
Very happy that our very own Ph.D. student Dila won the 3 min talk award at the Graduate Research Day @mcmasteruniversity.bsky.social Biology! Way to go 🎣! #zebrafish 🧪
March 6, 2025 at 2:01 AM
We hosted Tetsuto Miyashita from @museumofnature.bsky.social visiting us @mcmasteruniversity.bsky.social Biology! It was a truly inspiring seminar on #fossils and #Zebrafish (what else one really can ask for) and insightful discussions for all of us! 🧪
February 7, 2025 at 6:50 AM