Pauli Group (posts by Andi Pauli)
@pauligroup.bsky.social
Exploring the mysteries of how life starts - from fertilization to dormancy; combining in vivo & in vitro (fish, mouse, cell culture, biochem); privileged to work with an amazing team @IMP!
https://paulilab.org/
https://www.imp.ac.at/groups/andrea-pauli/
https://paulilab.org/
https://www.imp.ac.at/groups/andrea-pauli/
A big thank you to members of @pauligroup.bsky.social & @haselbachlab.bsky.social for ensuring a smooth meeting, and of course to our amazing conference organizer Manuela Steurer @impvienna.bsky.social - what would we organizers (O. Rissland, S. Shao, E. Bennett, myself) have done without you!
May 15, 2025 at 10:52 AM
A big thank you to members of @pauligroup.bsky.social & @haselbachlab.bsky.social for ensuring a smooth meeting, and of course to our amazing conference organizer Manuela Steurer @impvienna.bsky.social - what would we organizers (O. Rissland, S. Shao, E. Bennett, myself) have done without you!
The 2nd edition of the @embo.org workshop 'RNA meets Protein Decay', this time here in Vienna @impvienna.bsky.social, came to an end. Thanks to everyone who came and contributed to the great vibe of sharing science, discussing ideas and connecting with each other!
May 15, 2025 at 10:46 AM
The 2nd edition of the @embo.org workshop 'RNA meets Protein Decay', this time here in Vienna @impvienna.bsky.social, came to an end. Thanks to everyone who came and contributed to the great vibe of sharing science, discussing ideas and connecting with each other!
Switching fields and/or wanting to become an expert in #zebrafish research?
The @mblscience.bsky.social 2025 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field!
(New & final) Application deadline: March 28
www.mbl.edu/education/ad...
The @mblscience.bsky.social 2025 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field!
(New & final) Application deadline: March 28
www.mbl.edu/education/ad...
March 8, 2025 at 2:07 PM
Switching fields and/or wanting to become an expert in #zebrafish research?
The @mblscience.bsky.social 2025 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field!
(New & final) Application deadline: March 28
www.mbl.edu/education/ad...
The @mblscience.bsky.social 2025 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field!
(New & final) Application deadline: March 28
www.mbl.edu/education/ad...
The @pauligroup.bsky.social fertilization team @vdeneke.bsky.social, @johannessuwita.bsky.social, Andreas Blaha & Karin Panser visiting Masahito Ikawa's lab in Osaka, Japan. Thank you to 'Team Masa' for the amazing hospitality, for joining for experiments and lots of memorable and fun moments!
February 16, 2025 at 12:34 AM
The @pauligroup.bsky.social fertilization team @vdeneke.bsky.social, @johannessuwita.bsky.social, Andreas Blaha & Karin Panser visiting Masahito Ikawa's lab in Osaka, Japan. Thank you to 'Team Masa' for the amazing hospitality, for joining for experiments and lots of memorable and fun moments!
Switching fields to #zebrafish? Wanting to become an expert in zebrafish research? Check-out the @mblscience.bsky.social 2025 Zebrafish Development & Genetics course – a fantastic opportunity to learn from leaders in the field!
Application deadline: March 13
www.mbl.edu/education/ad...
Application deadline: March 13
www.mbl.edu/education/ad...
February 12, 2025 at 7:07 AM
Switching fields to #zebrafish? Wanting to become an expert in zebrafish research? Check-out the @mblscience.bsky.social 2025 Zebrafish Development & Genetics course – a fantastic opportunity to learn from leaders in the field!
Application deadline: March 13
www.mbl.edu/education/ad...
Application deadline: March 13
www.mbl.edu/education/ad...
Switching fields to #zebrafish? Wanting to become an expert in zebrafish research?
Check-out the @mblscience.bsky.social 2025 Zebrafish Development & Genetics course – a fantastic opportunity to learn from leaders in the field!
Application deadline: March 13
www.mbl.edu/education/ad...
Check-out the @mblscience.bsky.social 2025 Zebrafish Development & Genetics course – a fantastic opportunity to learn from leaders in the field!
Application deadline: March 13
www.mbl.edu/education/ad...
February 12, 2025 at 7:05 AM
Switching fields to #zebrafish? Wanting to become an expert in zebrafish research?
Check-out the @mblscience.bsky.social 2025 Zebrafish Development & Genetics course – a fantastic opportunity to learn from leaders in the field!
Application deadline: March 13
www.mbl.edu/education/ad...
Check-out the @mblscience.bsky.social 2025 Zebrafish Development & Genetics course – a fantastic opportunity to learn from leaders in the field!
Application deadline: March 13
www.mbl.edu/education/ad...
Immensely proud of our Andreas (now Dr. Blaha!) for a brilliant PhD defense on the ‘Mechanistic Analysis of Sperm-Egg Interaction in Vertebrates’ - we'll miss you but wish you all the best! Thank you to the examiners Ori Avinoam, Bill Snell and Uli Technau for their time and insightful questions.
February 8, 2025 at 8:23 PM
Immensely proud of our Andreas (now Dr. Blaha!) for a brilliant PhD defense on the ‘Mechanistic Analysis of Sperm-Egg Interaction in Vertebrates’ - we'll miss you but wish you all the best! Thank you to the examiners Ori Avinoam, Bill Snell and Uli Technau for their time and insightful questions.
Last three days to apply to our international @vbcscitraining.bsky.social summer school and Talents-for-Future program in Vienna! If you are an international bachelor/master student who is excited about committing this summer to world-class research and gaining new experiences, then this is for you!
January 12, 2025 at 11:17 AM
Last three days to apply to our international @vbcscitraining.bsky.social summer school and Talents-for-Future program in Vienna! If you are an international bachelor/master student who is excited about committing this summer to world-class research and gaining new experiences, then this is for you!
A year in the Pauli lab 'in pictures'. It's already a little tradition to look back at the many happy memories of the past year. Excited to see what 2025 will bring - may it be another happy, fun, successful and fulfilling year!
January 1, 2025 at 8:09 PM
A year in the Pauli lab 'in pictures'. It's already a little tradition to look back at the many happy memories of the past year. Excited to see what 2025 will bring - may it be another happy, fun, successful and fulfilling year!
And last but not least, a big thank you to Victoria @vdeneke.bsky.social and Andreas Blaha for preparing this thread, and to Victoria for capturing this wonderful movie of fertilization in zebrafish in all its beauty that was selected as cover image of this Cell issue (thank you Cell!)! (11/11)
December 13, 2024 at 7:43 PM
And last but not least, a big thank you to Victoria @vdeneke.bsky.social and Andreas Blaha for preparing this thread, and to Victoria for capturing this wonderful movie of fertilization in zebrafish in all its beauty that was selected as cover image of this Cell issue (thank you Cell!)! (11/11)
A big thank you to everyone who supported and contributed to this work! It was an amazing team effort spearheaded by @vdeneke.bsky.social & Andreas Blaha with key contributions from Yonggang Lu from Masahito Ikawa’s lab at Osaka University,… (8/11)
December 13, 2024 at 7:43 PM
A big thank you to everyone who supported and contributed to this work! It was an amazing team effort spearheaded by @vdeneke.bsky.social & Andreas Blaha with key contributions from Yonggang Lu from Masahito Ikawa’s lab at Osaka University,… (8/11)
Excitingly, this contrasts with mammals, where IZUMO1 interacts with JUNO, a evolutionarily and structurally unrelated protein to Bouncer.
Our work presents an intriguing model of a conserved complex bridging sperm and egg through divergent egg factors in vertebrates (7/11)
Our work presents an intriguing model of a conserved complex bridging sperm and egg through divergent egg factors in vertebrates (7/11)
December 13, 2024 at 7:43 PM
Excitingly, this contrasts with mammals, where IZUMO1 interacts with JUNO, a evolutionarily and structurally unrelated protein to Bouncer.
Our work presents an intriguing model of a conserved complex bridging sperm and egg through divergent egg factors in vertebrates (7/11)
Our work presents an intriguing model of a conserved complex bridging sperm and egg through divergent egg factors in vertebrates (7/11)
But what is this conserved sperm complex doing in fertilization?
AlphaFold predicted the zebrafish trimer to interact with the egg factor Bouncer. Not only do we confirm this prediction, we find that complex formation is required for Bouncer binding! (6/11)
AlphaFold predicted the zebrafish trimer to interact with the egg factor Bouncer. Not only do we confirm this prediction, we find that complex formation is required for Bouncer binding! (6/11)
December 13, 2024 at 7:43 PM
But what is this conserved sperm complex doing in fertilization?
AlphaFold predicted the zebrafish trimer to interact with the egg factor Bouncer. Not only do we confirm this prediction, we find that complex formation is required for Bouncer binding! (6/11)
AlphaFold predicted the zebrafish trimer to interact with the egg factor Bouncer. Not only do we confirm this prediction, we find that complex formation is required for Bouncer binding! (6/11)
In line with the AlphaFold prediction, we show that Tmem81, Izumo1, and Spaca6 interact in zebrafish sperm and that the human orthologs interact in vitro (5/11)
December 13, 2024 at 7:43 PM
In line with the AlphaFold prediction, we show that Tmem81, Izumo1, and Spaca6 interact in zebrafish sperm and that the human orthologs interact in vitro (5/11)
Together with Yonggang Lu in Masahito Ikawa’s group, we found that Tmem81 is essential for fertilization in zebrafish and mice (4/11)
December 13, 2024 at 7:43 PM
Together with Yonggang Lu in Masahito Ikawa’s group, we found that Tmem81 is essential for fertilization in zebrafish and mice (4/11)
This screen predicted a conserved sperm complex of Izumo1, Spaca6, and a new related factor, Tmem81, which had been previously uncharacterized in fertilization (3/11)
December 13, 2024 at 7:43 PM
This screen predicted a conserved sperm complex of Izumo1, Spaca6, and a new related factor, Tmem81, which had been previously uncharacterized in fertilization (3/11)
We ran all known fertilization factors in zebrafish against 1,400 testis proteins with the help of @86dominik.bsky.social (2/11)
December 13, 2024 at 7:43 PM
We ran all known fertilization factors in zebrafish against 1,400 testis proteins with the help of @86dominik.bsky.social (2/11)
The life of each of us began when a sperm and an egg came together. But what happens at a molecular level?
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
December 13, 2024 at 7:43 PM
The life of each of us began when a sperm and an egg came together. But what happens at a molecular level?
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
And last but not least, a big thank you to Victoria @vdeneke.bsky.social and Andreas Blaha for preparing this thread, and to Victoria for capturing this wonderful movie of fertilization in zebrafish in all its beauty that was selected as cover image of this Cell issue (thank you Cell!)! (11/11)
December 13, 2024 at 7:31 PM
And last but not least, a big thank you to Victoria @vdeneke.bsky.social and Andreas Blaha for preparing this thread, and to Victoria for capturing this wonderful movie of fertilization in zebrafish in all its beauty that was selected as cover image of this Cell issue (thank you Cell!)! (11/11)
A big thank you to everyone who supported and contributed to this work! It was an amazing team effort spearheaded by @vdeneke.bsky.social & Andreas Blaha with key contributions from Yonggang Lu from Masahito Ikawa’s lab at Osaka University,… (8/11)
December 13, 2024 at 7:31 PM
A big thank you to everyone who supported and contributed to this work! It was an amazing team effort spearheaded by @vdeneke.bsky.social & Andreas Blaha with key contributions from Yonggang Lu from Masahito Ikawa’s lab at Osaka University,… (8/11)
Excitingly, this contrasts with mammals, where IZUMO1 interacts with JUNO, a evolutionarily and structurally unrelated protein to Bouncer.
Our work presents an intriguing model of a conserved complex bridging sperm and egg through divergent egg factors in vertebrates (7/11)
Our work presents an intriguing model of a conserved complex bridging sperm and egg through divergent egg factors in vertebrates (7/11)
December 13, 2024 at 7:31 PM
Excitingly, this contrasts with mammals, where IZUMO1 interacts with JUNO, a evolutionarily and structurally unrelated protein to Bouncer.
Our work presents an intriguing model of a conserved complex bridging sperm and egg through divergent egg factors in vertebrates (7/11)
Our work presents an intriguing model of a conserved complex bridging sperm and egg through divergent egg factors in vertebrates (7/11)
But what is this conserved sperm complex doing in fertilization?
AlphaFold predicted the zebrafish trimer to interact with the egg factor Bouncer. Not only do we confirm this prediction, we find that complex formation is required for Bouncer binding! (6/11)
AlphaFold predicted the zebrafish trimer to interact with the egg factor Bouncer. Not only do we confirm this prediction, we find that complex formation is required for Bouncer binding! (6/11)
December 13, 2024 at 7:31 PM
But what is this conserved sperm complex doing in fertilization?
AlphaFold predicted the zebrafish trimer to interact with the egg factor Bouncer. Not only do we confirm this prediction, we find that complex formation is required for Bouncer binding! (6/11)
AlphaFold predicted the zebrafish trimer to interact with the egg factor Bouncer. Not only do we confirm this prediction, we find that complex formation is required for Bouncer binding! (6/11)
In line with the AlphaFold prediction, we show that Tmem81, Izumo1, and Spaca6 interact in zebrafish sperm and that the human orthologs interact in vitro (5/11)
December 13, 2024 at 7:31 PM
In line with the AlphaFold prediction, we show that Tmem81, Izumo1, and Spaca6 interact in zebrafish sperm and that the human orthologs interact in vitro (5/11)
Together with Yonggang Lu in Masahito Ikawa’s group, we found that Tmem81 is essential for fertilization in zebrafish and mice (4/11)
December 13, 2024 at 7:31 PM
Together with Yonggang Lu in Masahito Ikawa’s group, we found that Tmem81 is essential for fertilization in zebrafish and mice (4/11)
This screen predicted a conserved sperm complex of Izumo1, Spaca6, and a new related factor, Tmem81, which had been previously uncharacterized in fertilization (3/11)
December 13, 2024 at 7:31 PM
This screen predicted a conserved sperm complex of Izumo1, Spaca6, and a new related factor, Tmem81, which had been previously uncharacterized in fertilization (3/11)