Pauli Group (posts by Andi Pauli)
@pauligroup.bsky.social
Exploring the mysteries of how life starts - from fertilization to dormancy; combining in vivo & in vitro (fish, mouse, cell culture, biochem); privileged to work with an amazing team @IMP!
https://paulilab.org/
https://www.imp.ac.at/groups/andrea-pauli/
https://paulilab.org/
https://www.imp.ac.at/groups/andrea-pauli/
Pinned
The life of each of us began when a sperm and an egg came together. But what happens at a molecular level?
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
Reposted by Pauli Group (posts by Andi Pauli)
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted by Pauli Group (posts by Andi Pauli)
Join us at the Vienna BioCenter and @impvienna.bsky.social! Full disclaimer: I’m obviously biased but: mind-blowing facilities (!!!) and a great collaborative research culture make this an ideal place for anyone; especially suited to build up a lab. Plus Vienna is an amazing city to live in 😊
November 10, 2025 at 9:30 PM
Join us at the Vienna BioCenter and @impvienna.bsky.social! Full disclaimer: I’m obviously biased but: mind-blowing facilities (!!!) and a great collaborative research culture make this an ideal place for anyone; especially suited to build up a lab. Plus Vienna is an amazing city to live in 😊
Reposted by Pauli Group (posts by Andi Pauli)
HT-PELSA, a new proteomics tool by EMBL researchers, processes samples 100x faster and works directly with complex crude cell, tissue, and bacterial lysates – developments which could accelerate drug discovery and basic biological research 💊
🔗 www.embl.org/news/science...
🔗 www.embl.org/news/science...
November 5, 2025 at 10:09 AM
HT-PELSA, a new proteomics tool by EMBL researchers, processes samples 100x faster and works directly with complex crude cell, tissue, and bacterial lysates – developments which could accelerate drug discovery and basic biological research 💊
🔗 www.embl.org/news/science...
🔗 www.embl.org/news/science...
Reposted by Pauli Group (posts by Andi Pauli)
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 6, 2025 at 4:04 PM
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
Reposted by Pauli Group (posts by Andi Pauli)
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Alternate proteins from the same gene contribute differently to health and rare disease | Whitehead Institute
Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients thro...
wi.mit.edu
November 7, 2025 at 4:14 PM
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Reposted by Pauli Group (posts by Andi Pauli)
This Halloween, we have a spooky evolutionary story for you.
The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41...
Here’s why I love this work — and why I think you’ll enjoy it too. 👇
The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41...
Here’s why I love this work — and why I think you’ll enjoy it too. 👇
October 31, 2025 at 10:19 AM
This Halloween, we have a spooky evolutionary story for you.
The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41...
Here’s why I love this work — and why I think you’ll enjoy it too. 👇
The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41...
Here’s why I love this work — and why I think you’ll enjoy it too. 👇
Reposted by Pauli Group (posts by Andi Pauli)
Very happy to share our latest work extending iterative immunofluorescence to in toto imaging of early zebrafish embryos (3D-4i), integrated with a 3D-dedicated image analysis pipeline! 🐟🔬📊
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
October 29, 2025 at 2:20 PM
Very happy to share our latest work extending iterative immunofluorescence to in toto imaging of early zebrafish embryos (3D-4i), integrated with a 3D-dedicated image analysis pipeline! 🐟🔬📊
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
Why curiosity-driven research is so fundamental & important, and requires sufficient funding. It's a corner stone of scientific discovery, which has always been and will always be inherently unpredictable!!
Nektarios Tavernarakis on why curiosity-driven research, not focusing on application, is fundamental to problem solving and requires government support in @emboreports.org doi.org/10.1038/s443...
For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
doi.org
October 29, 2025 at 2:39 PM
Why curiosity-driven research is so fundamental & important, and requires sufficient funding. It's a corner stone of scientific discovery, which has always been and will always be inherently unpredictable!!
Fantastic to see this Stela Jelenic's PhD work (@vbcscitraining.bsky.social PhD student) out in EMBO Journal! www.embopress.org/doi/full/10....
Germ granule localization of nematode Argonaute WAGO-4 ensures fidelity in small RNA loading | The EMBO Journal
imageimageGerm granule localization is a conserved feature of many Argonautes (Agos), but its
functional significance remains unclear. This work suggests that for the Ago WAGO-4,
spatial enrichment in...
www.embopress.org
October 27, 2025 at 1:25 PM
Fantastic to see this Stela Jelenic's PhD work (@vbcscitraining.bsky.social PhD student) out in EMBO Journal! www.embopress.org/doi/full/10....
Reposted by Pauli Group (posts by Andi Pauli)
In our latest interview, Kristina Stapornwongkul, the newest group leader at IMBA, shares her journey to joining the institute, why she chose IMBA as the next step in her career, and her vision for her lab exploring how metabolism shapes embryonic development: https://imba.science/49fCrxl
October 27, 2025 at 8:00 AM
In our latest interview, Kristina Stapornwongkul, the newest group leader at IMBA, shares her journey to joining the institute, why she chose IMBA as the next step in her career, and her vision for her lab exploring how metabolism shapes embryonic development: https://imba.science/49fCrxl
Reposted by Pauli Group (posts by Andi Pauli)
Sex cells made from scratch could revolutionize human reproduction, but researchers are struggling to translate promising results in mice into benefits for humans, according to a feature in Nature. 🧪
The quest to make babies with lab-grown eggs and sperm
Sex cells made from scratch could revolutionize human reproduction. But researchers are struggling to translate promising results in mice into benefits for humans.
go.nature.com
October 21, 2025 at 1:19 PM
Sex cells made from scratch could revolutionize human reproduction, but researchers are struggling to translate promising results in mice into benefits for humans, according to a feature in Nature. 🧪
Reposted by Pauli Group (posts by Andi Pauli)
Today @anthropic.com released PubMed integration for Claude. No hallucinations. Just real science, real data. As a beta tester, this has been game changing— a supercharged research tool. Here are 6 prompts that will transform how you search the literature. A 🧵
www.anthropic.com/news/claude-...
www.anthropic.com/news/claude-...
Claude for Life Sciences
Discover how Claude accelerates life sciences research with new scientific connectors, skills, and improved performance for drug discovery and clinical work.
www.anthropic.com
October 20, 2025 at 5:27 PM
Today @anthropic.com released PubMed integration for Claude. No hallucinations. Just real science, real data. As a beta tester, this has been game changing— a supercharged research tool. Here are 6 prompts that will transform how you search the literature. A 🧵
www.anthropic.com/news/claude-...
www.anthropic.com/news/claude-...
Reposted by Pauli Group (posts by Andi Pauli)
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
October 18, 2025 at 6:59 PM
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Reposted by Pauli Group (posts by Andi Pauli)
Congrats @laurentformery.bsky.social
Often people ask why we chose to work on a certain problems and a simple answer for us in this case - it’s beautiful. If you want to learn the magic of building crystalline « gems » inside the body - see our latest paper at www.biorxiv.org/content/10.1...
Often people ask why we chose to work on a certain problems and a simple answer for us in this case - it’s beautiful. If you want to learn the magic of building crystalline « gems » inside the body - see our latest paper at www.biorxiv.org/content/10.1...
October 18, 2025 at 8:18 PM
Congrats @laurentformery.bsky.social
Often people ask why we chose to work on a certain problems and a simple answer for us in this case - it’s beautiful. If you want to learn the magic of building crystalline « gems » inside the body - see our latest paper at www.biorxiv.org/content/10.1...
Often people ask why we chose to work on a certain problems and a simple answer for us in this case - it’s beautiful. If you want to learn the magic of building crystalline « gems » inside the body - see our latest paper at www.biorxiv.org/content/10.1...
Reposted by Pauli Group (posts by Andi Pauli)
When transposons jump, genomes diverge - even in cultured cells.
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
October 14, 2025 at 8:34 PM
When transposons jump, genomes diverge - even in cultured cells.
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
Big congrats to all, to @imbmainz.bsky.social on this amazing 'double-catch', and of course to @hohmannulrich.bsky.social & @lorenzoorts.bsky.social for starting their own labs!
To prospective PhD students interested in mechanistic question in gene regulation, check out Laura's & Ulrich's labs!
To prospective PhD students interested in mechanistic question in gene regulation, check out Laura's & Ulrich's labs!
Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
October 12, 2025 at 9:14 PM
Big congrats to all, to @imbmainz.bsky.social on this amazing 'double-catch', and of course to @hohmannulrich.bsky.social & @lorenzoorts.bsky.social for starting their own labs!
To prospective PhD students interested in mechanistic question in gene regulation, check out Laura's & Ulrich's labs!
To prospective PhD students interested in mechanistic question in gene regulation, check out Laura's & Ulrich's labs!
Very sweet ;-)! Big congrats to the entire team!!
🧪 How does cancer turn sour into power?
Cancer cells thrive in hostile, acidic environments.
A team led by Johannes Zuber (IMP) & Wilhelm Palm (DKFZ) shows that acidosis acts as a master switch, rewiring tumour metabolism and boosting resilience.
➡️ www.science.org/doi/10.1126/...
Cancer cells thrive in hostile, acidic environments.
A team led by Johannes Zuber (IMP) & Wilhelm Palm (DKFZ) shows that acidosis acts as a master switch, rewiring tumour metabolism and boosting resilience.
➡️ www.science.org/doi/10.1126/...
October 9, 2025 at 6:20 PM
Very sweet ;-)! Big congrats to the entire team!!
Congratulations to @vdeneke.bsky.social & Andreas Blaha @impvienna.bsky.social for their research on vertebrate fertilization, which was awarded this year's ÖGMBT Life Science Research Award in Austria for basic research!
🎉Congrats to our @vdeneke.bsky.social, postdoc in the @pauligroup.bsky.social, who has received the 2025 Life Sciences Research Award Austria from the ÖGMBT!
She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...
She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...
October 5, 2025 at 8:46 PM
Congratulations to @vdeneke.bsky.social & Andreas Blaha @impvienna.bsky.social for their research on vertebrate fertilization, which was awarded this year's ÖGMBT Life Science Research Award in Austria for basic research!
Reposted by Pauli Group (posts by Andi Pauli)
The Vienna BioCenter PhD Program application deadline is approaching: October 10!
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
October 5, 2025 at 9:35 AM
The Vienna BioCenter PhD Program application deadline is approaching: October 10!
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Are you interested in the mechanisms of mRNA regulation in the early embryo and are looking for a great lab to start your PhD? Then check out this amazing opportunity with my outgoing postdoc @lorenzoorts.bsky.social who will start her own lab - I can highly recommend to apply!
I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October.
More info: www.imb.de/students-pos...
More info: www.imb.de/students-pos...
Laura Lorenzo Orts
IMB Mainz
www.imb.de
September 20, 2025 at 6:43 AM
Are you interested in the mechanisms of mRNA regulation in the early embryo and are looking for a great lab to start your PhD? Then check out this amazing opportunity with my outgoing postdoc @lorenzoorts.bsky.social who will start her own lab - I can highly recommend to apply!
Wonderful news, and big congratulations to my dear friend, colleague, and brilliant scientist @obenaufa.bsky.social for winning this major Award! Super happy for you!
Congratulations to our @obenaufa.bsky.social on receiving the highly prestigious Dr. Josef Steiner Cancer Research Award 2025! 🎉
Read more in this interview with Anna: www.imp.ac.at/news/article...
Read more in this interview with Anna: www.imp.ac.at/news/article...
September 12, 2025 at 5:01 PM
Wonderful news, and big congratulations to my dear friend, colleague, and brilliant scientist @obenaufa.bsky.social for winning this major Award! Super happy for you!
Reposted by Pauli Group (posts by Andi Pauli)
Congratulations to these brilliant young scientists for winning the Birnstiel Award 2025 for their discoveries during their PhDs!
A big round of applause also for all runners-up & nominees, and thank you to all institutions who nominated their very best PhD students for this international award!
A big round of applause also for all runners-up & nominees, and thank you to all institutions who nominated their very best PhD students for this international award!
Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2025!
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
September 10, 2025 at 5:23 PM
Congratulations to these brilliant young scientists for winning the Birnstiel Award 2025 for their discoveries during their PhDs!
A big round of applause also for all runners-up & nominees, and thank you to all institutions who nominated their very best PhD students for this international award!
A big round of applause also for all runners-up & nominees, and thank you to all institutions who nominated their very best PhD students for this international award!
Reposted by Pauli Group (posts by Andi Pauli)
The Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Have a look at what our campus has to offer: www.vbcphd.at
September 7, 2025 at 12:48 PM
The Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Have a look at what our campus has to offer: www.vbcphd.at
Reposted by Pauli Group (posts by Andi Pauli)
🌍🧬 This summer, the Vienna BioCenter Summer School hosted talented, young scientists from around the world for 9 weeks.
@viennabiocenter.bsky.social
@viennabiocenter.bsky.social
September 6, 2025 at 1:27 PM
🌍🧬 This summer, the Vienna BioCenter Summer School hosted talented, young scientists from around the world for 9 weeks.
@viennabiocenter.bsky.social
@viennabiocenter.bsky.social