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patternyx.bsky.social
@patternyx.bsky.social
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natbiotech.nature.com
Ad hoc, post hoc and intrinsic-hoc in bioinformatics go.nature.com/4oJTzji
Ad hoc, post hoc and intrinsic-hoc in bioinformatics - Nature Biotechnology
Nature Biotechnology - Ad hoc, post hoc and intrinsic-hoc in bioinformatics
go.nature.com
October 30, 2025 at 4:46 PM
Reposted
natbiotech.nature.com
A trimodal protein language model enables advanced protein searches go.nature.com/4pSGJRf
A trimodal protein language model enables advanced protein searches - Nature Biotechnology
A protein foundation model represents protein sequence, structure and function.
go.nature.com
October 2, 2025 at 3:13 PM
Reposted
mendell-lab.bsky.social
I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....
www.science.org
November 22, 2024 at 6:09 PM
Reposted
lapassmore.bsky.social
New work from Matti Turtola showing that mRNA poly(A) tail length is controlled by a kinetic ruler. A real pleasure to work with him!
www.biorxiv.org/content/10.1...
A kinetic ruler controls mRNA poly(A) tail length
Poly(A) tails of newly synthesized mRNAs have uniform lengths, arising through cooperation between the cleavage and polyadenylation complex (CPAC) and poly(A) binding proteins (PABPs). In the budding ...
www.biorxiv.org
May 2, 2025 at 5:10 PM
Reposted
natbiotech.nature.com
A machine learning model for prime editing efficiency prediction takes into account chromatin context go.nature.com/3VQNmq9
rdcu.be/em3Yi
Machine learning prediction of prime editing efficiency across diverse chromatin contexts - Nature Biotechnology
A machine learning model for prime editing efficiency prediction takes into account chromatin context.
go.nature.com
June 7, 2025 at 4:21 AM
Reposted
natbiotech.nature.com
Complete 5-methylcytidine substitution enhances the efficacy of self-amplifying RNA go.nature.com/3RYbPHK
rdcu.be/em3ZT
Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency - Nature Biotechnology
Complete 5-methylcytidine substitution enhances the efficacy of self-amplifying RNA.
go.nature.com
May 27, 2025 at 3:26 AM