Osman Lab
@osman-lab.bsky.social
Studying the mysteries that surround the genome of the cell's powerhouse
Reposted by Osman Lab
🚨 Preprint alert! 🚨
My first first-author manuscript is out on bioRxiv!
We developed a new method to monitor mtDNA quality control in yeast, and found that a functional respiratory chain is crucial for the process. @osman-lab.bsky.social
#mtDNA #mitochondria
www.biorxiv.org/content/10.1...
My first first-author manuscript is out on bioRxiv!
We developed a new method to monitor mtDNA quality control in yeast, and found that a functional respiratory chain is crucial for the process. @osman-lab.bsky.social
#mtDNA #mitochondria
www.biorxiv.org/content/10.1...
Local Mitochondrial Physiology Defined by mtDNA Quality Guides Purifying Selection
The mitochondrial genome (mtDNA) encodes essential subunits of the electron transport chain and ATP synthase. Mutations in these genes impair oxidative phosphorylation, compromise mitochondrial ATP pr...
www.biorxiv.org
August 12, 2025 at 7:49 AM
🚨 Preprint alert! 🚨
My first first-author manuscript is out on bioRxiv!
We developed a new method to monitor mtDNA quality control in yeast, and found that a functional respiratory chain is crucial for the process. @osman-lab.bsky.social
#mtDNA #mitochondria
www.biorxiv.org/content/10.1...
My first first-author manuscript is out on bioRxiv!
We developed a new method to monitor mtDNA quality control in yeast, and found that a functional respiratory chain is crucial for the process. @osman-lab.bsky.social
#mtDNA #mitochondria
www.biorxiv.org/content/10.1...
Reposted by Osman Lab
Lost in translation? Chloroplasts can handle slang!
New study from our group at @lmumuenchen.bsky.social with great collabs @plantproteomics-ms.bsky.social @ifink-lab.bsky.social bsky.social @hhu.de @wsupullman.bsky.social https://www.biorxiv.org/content/10.1101/2025.03.07.642005v1 🧵Often assumed
New study from our group at @lmumuenchen.bsky.social with great collabs @plantproteomics-ms.bsky.social @ifink-lab.bsky.social bsky.social @hhu.de @wsupullman.bsky.social https://www.biorxiv.org/content/10.1101/2025.03.07.642005v1 🧵Often assumed
March 9, 2025 at 8:21 AM
Lost in translation? Chloroplasts can handle slang!
New study from our group at @lmumuenchen.bsky.social with great collabs @plantproteomics-ms.bsky.social @ifink-lab.bsky.social bsky.social @hhu.de @wsupullman.bsky.social https://www.biorxiv.org/content/10.1101/2025.03.07.642005v1 🧵Often assumed
New study from our group at @lmumuenchen.bsky.social with great collabs @plantproteomics-ms.bsky.social @ifink-lab.bsky.social bsky.social @hhu.de @wsupullman.bsky.social https://www.biorxiv.org/content/10.1101/2025.03.07.642005v1 🧵Often assumed
🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae, Mrx6 belongs to the Pet20-domain-containing ...
www.biorxiv.org
February 16, 2025 at 2:04 PM
🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA
Reposted by Osman Lab
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number https://www.biorxiv.org/content/10.1101/2025.02.14.638270v1
February 16, 2025 at 12:32 PM
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number https://www.biorxiv.org/content/10.1101/2025.02.14.638270v1
Reposted by Osman Lab
Akshaya Seshadri and Anjana Badrinarayanan @anjbadri.bsky.social @ncbsbangalore.bsky.social @tifrscience.bsky.social show that exonuclease action of replicative #polymerase gamma drives damage-induced #mitochondria #DNA clearance. New mechanism of mtDNA clearance.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
February 1, 2025 at 11:41 AM
Akshaya Seshadri and Anjana Badrinarayanan @anjbadri.bsky.social @ncbsbangalore.bsky.social @tifrscience.bsky.social show that exonuclease action of replicative #polymerase gamma drives damage-induced #mitochondria #DNA clearance. New mechanism of mtDNA clearance.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Osman Lab
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 23, 2024 at 5:49 PM
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Osman Lab
And here's the thread by @gavsturm.bsky.social explaining their herculean and fascinating work on #pearling #biophysics!
December 23, 2024 at 5:01 PM
And here's the thread by @gavsturm.bsky.social explaining their herculean and fascinating work on #pearling #biophysics!
Reposted by Osman Lab
@osman-lab.bsky.social < is that you > @osman_lab on 𝕏 ?
@felix_thoma on 𝕏 Apr 25, 2022
"Mitochondrial dynamics in budding yeast. A picture was taken every 3 min for 5 h. I used mKate2 targeted to the mitos, and imaged the cells in a microfluidic chamber with a Nikon Ti2e Eclipse"
need this here!
@felix_thoma on 𝕏 Apr 25, 2022
"Mitochondrial dynamics in budding yeast. A picture was taken every 3 min for 5 h. I used mKate2 targeted to the mitos, and imaged the cells in a microfluidic chamber with a Nikon Ti2e Eclipse"
need this here!
December 5, 2024 at 11:06 AM
@osman-lab.bsky.social < is that you > @osman_lab on 𝕏 ?
@felix_thoma on 𝕏 Apr 25, 2022
"Mitochondrial dynamics in budding yeast. A picture was taken every 3 min for 5 h. I used mKate2 targeted to the mitos, and imaged the cells in a microfluidic chamber with a Nikon Ti2e Eclipse"
need this here!
@felix_thoma on 𝕏 Apr 25, 2022
"Mitochondrial dynamics in budding yeast. A picture was taken every 3 min for 5 h. I used mKate2 targeted to the mitos, and imaged the cells in a microfluidic chamber with a Nikon Ti2e Eclipse"
need this here!