Olivier Belli
@olivier-belli.bsky.social
PhD @ ETH Zürich 🎓
Gene editing expert, interested in genetic variants and drug resistance.
Gene editing expert, interested in genetic variants and drug resistance.
Pinned
Olivier Belli
@olivier-belli.bsky.social
· Nov 19
Multimodal scanning of genetic variants with base and prime editing - Nature Biotechnology
Thousands of rare oncogene variants are evaluated using multimodal gene editing screens.
www.nature.com
🚨 Very happy to announce the publication of my PhD work
@naturebiotech.bsky.social where we combined base and prime editing screens to investigate the impact of genetic variants in cancer. 🧵⬇️
@naturebiotech.bsky.social where we combined base and prime editing screens to investigate the impact of genetic variants in cancer. 🧵⬇️
Reposted by Olivier Belli
A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG
rdcu.be/d9iRG
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
Nature Immunology - Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform...
rdcu.be
February 11, 2025 at 9:57 AM
A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG
rdcu.be/d9iRG
Reposted by Olivier Belli
We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
www.science.org
January 31, 2025 at 1:49 PM
We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
An interesting read that moves away from the 'blueprint of life' approach to the genome and instead compares it to generative AI models.
The Genomic Code: The genome instantiates a generative model of the organism
How does the genome encode the form of the organism? What is the nature of this genomic code? Inspired by recent work in machine learning and neuroscience, we propose that the genome encodes a generat...
arxiv.org
January 31, 2025 at 5:56 PM
An interesting read that moves away from the 'blueprint of life' approach to the genome and instead compares it to generative AI models.
Reposted by Olivier Belli
While the risk of human-to-human transmission is still low, the pervasive reservoirs and appearance of new, concerning mutations or those identified as a threat science.org/doi/10.1126/...
demand a very high level of vigilance and preparedness
demand a very high level of vigilance and preparedness
A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors
In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-h...
science.org
December 31, 2024 at 11:44 PM
While the risk of human-to-human transmission is still low, the pervasive reservoirs and appearance of new, concerning mutations or those identified as a threat science.org/doi/10.1126/...
demand a very high level of vigilance and preparedness
demand a very high level of vigilance and preparedness
Reposted by Olivier Belli
We are pursuing the wrong applications for AI.
December 22, 2024 at 2:36 PM
We are pursuing the wrong applications for AI.
One powerful application of precision genome editing screens: functional assays can help address the underrepresentation of patients with non-European genetic ancestries in variant databases, reducing delays in diagnoses and improving treatment accuracy
December 9, 2024 at 9:05 PM
One powerful application of precision genome editing screens: functional assays can help address the underrepresentation of patients with non-European genetic ancestries in variant databases, reducing delays in diagnoses and improving treatment accuracy
I had a nice chat with CRISPR Medicine News to discuss our work on precision genome editing screens and their applications in cancer therapy.
News: Multimodal Editing Maps Genetic Variants in EGFR - CRISPR Medicine
Researchers at ETH Zürich have introduced a combined base and prime editing approach to explore the mutational landscape of the epithelial growth factor receptor (EGFR) gene. This strategy provides a ...
crisprmedicinenews.com
December 6, 2024 at 12:17 PM
I had a nice chat with CRISPR Medicine News to discuss our work on precision genome editing screens and their applications in cancer therapy.
Reposted by Olivier Belli
Reading: www.science.org/content/arti... "War-torn Ukraine has become a breeding ground for lethal drug-resistant bacteria" #AMR
War-torn Ukraine has become a breeding ground for lethal drug-resistant bacteria
Urgent action underway to prevent dangerous microbes from spreading beyond country's borders
www.science.org
November 30, 2024 at 12:48 AM
Reading: www.science.org/content/arti... "War-torn Ukraine has become a breeding ground for lethal drug-resistant bacteria" #AMR
Reposted by Olivier Belli
Orcas have started wearing dead salmon as hats again, just fyi
www.iflscience.com/wearing-a-sa...
www.iflscience.com/wearing-a-sa...
Wearing A Salmon On Your Head Is Back In Fashion For Orcas, After A 37-Year Break
In 1987, there was a strange trend amongst killer whales. Recent sightings show it's back in fashion.
www.iflscience.com
November 27, 2024 at 3:50 PM
Orcas have started wearing dead salmon as hats again, just fyi
www.iflscience.com/wearing-a-sa...
www.iflscience.com/wearing-a-sa...
Reposted by Olivier Belli
1/ Influenza wastewater activity levels are currently low across the US, aside from conspicuous areas in CA where #H5N1 is spreading in dairy cows.
A deeper dive into the Wastewater Scan data paints a very concerning picture and should add to our sense of urgency.
A deeper dive into the Wastewater Scan data paints a very concerning picture and should add to our sense of urgency.
November 26, 2024 at 10:06 PM
1/ Influenza wastewater activity levels are currently low across the US, aside from conspicuous areas in CA where #H5N1 is spreading in dairy cows.
A deeper dive into the Wastewater Scan data paints a very concerning picture and should add to our sense of urgency.
A deeper dive into the Wastewater Scan data paints a very concerning picture and should add to our sense of urgency.
Reposted by Olivier Belli
Wouldn't it be lovely to live in a world where we knew what every single amino acid change would do to patient response to therapy?
We are getting there with these two exciting prime editing studies!
#CanSky
#MEDsky
💻🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We are getting there with these two exciting prime editing studies!
#CanSky
#MEDsky
💻🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Saturation profiling of drug-resistant genetic variants using prime editing - Nature Biotechnology
PEER-seq characterizes the drug resistance profiles of thousands of genetic variants.
www.nature.com
November 14, 2024 at 9:55 PM
Wouldn't it be lovely to live in a world where we knew what every single amino acid change would do to patient response to therapy?
We are getting there with these two exciting prime editing studies!
#CanSky
#MEDsky
💻🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We are getting there with these two exciting prime editing studies!
#CanSky
#MEDsky
💻🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Olivier Belli
Multimodal scanning of genetic variants with base and prime editing go.nature.com/3O6wQ0O
Multimodal scanning of genetic variants with base and prime editing - Nature Biotechnology
Thousands of rare oncogene variants are evaluated using multimodal gene editing screens.
go.nature.com
November 13, 2024 at 10:59 PM
Multimodal scanning of genetic variants with base and prime editing go.nature.com/3O6wQ0O
🚨 Very happy to announce the publication of my PhD work
@naturebiotech.bsky.social where we combined base and prime editing screens to investigate the impact of genetic variants in cancer. 🧵⬇️
@naturebiotech.bsky.social where we combined base and prime editing screens to investigate the impact of genetic variants in cancer. 🧵⬇️
Multimodal scanning of genetic variants with base and prime editing - Nature Biotechnology
Thousands of rare oncogene variants are evaluated using multimodal gene editing screens.
www.nature.com
November 19, 2024 at 11:52 PM
🚨 Very happy to announce the publication of my PhD work
@naturebiotech.bsky.social where we combined base and prime editing screens to investigate the impact of genetic variants in cancer. 🧵⬇️
@naturebiotech.bsky.social where we combined base and prime editing screens to investigate the impact of genetic variants in cancer. 🧵⬇️