Oleg Dmytrenko
@olehdmy.bsky.social
Microbiologist, CRISPR imposter
Russia is a terrorist state!
April 24, 2025 at 5:28 AM
Russia is a terrorist state!
Preprint alert: Putative phages with dsRNA genomes. Intriguing what bacteria they may infect. Nature’s diversity continues to astonish! www.biorxiv.org/content/10.1...
“Paraxenoviridae”, a putative family of ubiquitous marine bacteriophages with double-stranded RNA genomes
Fragmented and primer Ligated DsRNA Sequencing (FLDS) was used to reconstruct five complete, bisegmented RNA genomes of paraxenoviruses, a group of viruses that was previously identified in the ocean ...
www.biorxiv.org
March 5, 2025 at 4:59 PM
Preprint alert: Putative phages with dsRNA genomes. Intriguing what bacteria they may infect. Nature’s diversity continues to astonish! www.biorxiv.org/content/10.1...
Reposted by Oleg Dmytrenko
The Russian spelling and pronunciation of Kyiv throughout the ages was no accident. While the name gets its origin from an empire that predates Russia, a series of policies by the Russian Empire and the Soviet Union that sought to Russify Ukraine and the Ukrainian language distorted its roots.
Kyiv, not Kiev — How Ukrainians reclaimed their capital
For decades, if not more, English speakers the world over referred to Ukraine’s capital as Kiev, pronouncing it kee-yev.
Few people knew they were using the Russian name for the city. The city is pro...
kyivindependent.com
March 3, 2025 at 1:12 PM
The Russian spelling and pronunciation of Kyiv throughout the ages was no accident. While the name gets its origin from an empire that predates Russia, a series of policies by the Russian Empire and the Soviet Union that sought to Russify Ukraine and the Ukrainian language distorted its roots.
I’m very fortunate to be at the 2025 CRISPR Meeting in Christchurch to share our latest work on the quirky Cas12a diversity. What an amazing crowd and location!
@crisprmeeting.bsky.social
@crisprmeeting.bsky.social
February 18, 2025 at 7:02 PM
I’m very fortunate to be at the 2025 CRISPR Meeting in Christchurch to share our latest work on the quirky Cas12a diversity. What an amazing crowd and location!
@crisprmeeting.bsky.social
@crisprmeeting.bsky.social
The diversity of microbial defenses is amazing! Type IV Thoeris system shows an ancient innate immunity mechanism which uses a TIR protein to make N7-cADPR, activating a caspase-like protease to block phages. Learn more: www.science.org/doi/10.1126/...
TIR signaling activates caspase-like immunity in bacteria
Caspase family proteases and Toll/interleukin-1 receptor (TIR)-domain proteins have central roles in innate immunity and regulated cell death in humans. We describe a bacterial immune system comprisin...
www.science.org
February 1, 2025 at 7:34 PM
The diversity of microbial defenses is amazing! Type IV Thoeris system shows an ancient innate immunity mechanism which uses a TIR protein to make N7-cADPR, activating a caspase-like protease to block phages. Learn more: www.science.org/doi/10.1126/...
Reposted by Oleg Dmytrenko
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
January 30, 2025 at 3:40 AM
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
Das Ende einer Ära: Heute fand die allerletzte Klasse in meinem geliebten Yogastudio statt, das mir in den letzten sechs Jahren ein Zufluchtsort war. Danke, Clau, für all die Posen und erholsamen Savasanas.
January 26, 2025 at 1:40 PM
Das Ende einer Ära: Heute fand die allerletzte Klasse in meinem geliebten Yogastudio statt, das mir in den letzten sechs Jahren ein Zufluchtsort war. Danke, Clau, für all die Posen und erholsamen Savasanas.
This is just wild: using AI-driven structural predictions, this study discovered how a phage-encoded “Cas12 hacker” hijacks the bacterial host’s thioredoxin enzyme to supercharge its DNA-cleaving ability. www.biorxiv.org/content/10.1...
AI-driven discovery of host thioredoxin as a CRISPR enhancer of phage-encoded miniature Cas12 hacker nuclease
The evolutionary arms race between bacteriophages and their bacterial hosts has driven the evolution of sophisticated adaptive immune systems, such as CRISPR-Cas, as a crucial defense mechanism. While...
www.biorxiv.org
January 21, 2025 at 2:30 PM
This is just wild: using AI-driven structural predictions, this study discovered how a phage-encoded “Cas12 hacker” hijacks the bacterial host’s thioredoxin enzyme to supercharge its DNA-cleaving ability. www.biorxiv.org/content/10.1...
An excellent review on direct Nanopore sequencing of RNA for detecting epigenetic modifications. We are clearly just at the beginning of this journey, with many exciting discoveries to come. www.sciencedirect.com/science/arti...
Charting the epitranscriptomic landscape across RNA biotypes using native RNA nanopore sequencing
RNA modifications are conserved chemical features found in all domains of life and across diverse RNA biotypes, shaping gene expression profiles and e…
www.sciencedirect.com
January 21, 2025 at 8:46 AM
An excellent review on direct Nanopore sequencing of RNA for detecting epigenetic modifications. We are clearly just at the beginning of this journey, with many exciting discoveries to come. www.sciencedirect.com/science/arti...
Reposted by Oleg Dmytrenko
🧬 Save the date! The EMBO Workshop "The Immune System of Bacteria" will uncover groundbreaking insights into bacterial defense systems. Join us April 8-10, 2025, at Institut Pasteur, Paris. Submit your abstracts by Feb. 28 👉 https://www.sisb2025.conferences-pasteur.org/home
January 16, 2025 at 2:45 PM
🧬 Save the date! The EMBO Workshop "The Immune System of Bacteria" will uncover groundbreaking insights into bacterial defense systems. Join us April 8-10, 2025, at Institut Pasteur, Paris. Submit your abstracts by Feb. 28 👉 https://www.sisb2025.conferences-pasteur.org/home
An excellent review on nucleic acid recognition in microbial immunity! www.cell.com/molecular-ce...
Nucleic acid recognition during prokaryotic immunity
Prokaryotes sense viral and plasmid nucleic acids to start defense pathways against
these invaders. This review examines the different mechanisms of DNA and RNA recognition
and how these distinguish s...
www.cell.com
January 16, 2025 at 8:42 PM
An excellent review on nucleic acid recognition in microbial immunity! www.cell.com/molecular-ce...
Reposted by Oleg Dmytrenko
Registration now open for the EMBO Workshop: Immune System of Bacteria !!!!
www.sisb2025.conferences-pasteur.org/home
Joins us in Institut Pasteur, Paris, April 8-10th.
www.sisb2025.conferences-pasteur.org/home
Joins us in Institut Pasteur, Paris, April 8-10th.
December 9, 2024 at 12:52 PM
Registration now open for the EMBO Workshop: Immune System of Bacteria !!!!
www.sisb2025.conferences-pasteur.org/home
Joins us in Institut Pasteur, Paris, April 8-10th.
www.sisb2025.conferences-pasteur.org/home
Joins us in Institut Pasteur, Paris, April 8-10th.
Happy 🦃 day, everyone!
November 28, 2024 at 3:07 PM
Happy 🦃 day, everyone!