Ole Christian Sylte
@olechsylte.bsky.social
Neuroscientist, postdoc in Stephenson-Jones lab at Sainsbury Wellcome Centre, UCL
Pinned
Coordinated representational drift supports stable place coding in hippocampal CA1
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...
www.biorxiv.org
Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics.
New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇
New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇
Reposted by Ole Christian Sylte
Now that the science days are over, I can happily share some of my designs :)
Thanks to all the @in-code.bsky.social members who made these days a success! It was intense but worth it!
And huge thanks to @sophiekb.bsky.social that was in charge of making this happen
Thanks to all the @in-code.bsky.social members who made these days a success! It was intense but worth it!
And huge thanks to @sophiekb.bsky.social that was in charge of making this happen
October 27, 2025 at 3:12 PM
Now that the science days are over, I can happily share some of my designs :)
Thanks to all the @in-code.bsky.social members who made these days a success! It was intense but worth it!
And huge thanks to @sophiekb.bsky.social that was in charge of making this happen
Thanks to all the @in-code.bsky.social members who made these days a success! It was intense but worth it!
And huge thanks to @sophiekb.bsky.social that was in charge of making this happen
Reposted by Ole Christian Sylte
🙋Are you interested in bridging theory & experiments?
Applications are now open for 2026 entry to the Gatsby Unit & SWC joint PhD programme.
Join us and be part of a vibrant research community!
💰 Fully-funded 4-year programme
ℹ️ www.ucl.ac.uk/life-science...
@sainsburywellcome.bsky.social
Applications are now open for 2026 entry to the Gatsby Unit & SWC joint PhD programme.
Join us and be part of a vibrant research community!
💰 Fully-funded 4-year programme
ℹ️ www.ucl.ac.uk/life-science...
@sainsburywellcome.bsky.social
September 25, 2025 at 10:09 AM
🙋Are you interested in bridging theory & experiments?
Applications are now open for 2026 entry to the Gatsby Unit & SWC joint PhD programme.
Join us and be part of a vibrant research community!
💰 Fully-funded 4-year programme
ℹ️ www.ucl.ac.uk/life-science...
@sainsburywellcome.bsky.social
Applications are now open for 2026 entry to the Gatsby Unit & SWC joint PhD programme.
Join us and be part of a vibrant research community!
💰 Fully-funded 4-year programme
ℹ️ www.ucl.ac.uk/life-science...
@sainsburywellcome.bsky.social
Reposted by Ole Christian Sylte
Applications are now open for the SWC Systems Neuroscience PhD Programme.
Join us in London!
🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social
Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
Join us in London!
🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social
Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
September 23, 2025 at 8:47 AM
Applications are now open for the SWC Systems Neuroscience PhD Programme.
Join us in London!
🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social
Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
Join us in London!
🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social
Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
Reposted by Ole Christian Sylte
🚨New paper alert! We studied the long-term consequences of SSRI use during pregnancy on the offspring in rats in a seminatural environment. We found that perinatal FLX exposure significantly increases sexual behavior in adult male rats.
@uitnorgesarktiske.bsky.social
#neuroscience #neuroskyence
@uitnorgesarktiske.bsky.social
#neuroscience #neuroskyence
Perinatal fluoxetine exposure increases male rat sexual behavior
Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to pregnant women due to their efficacy and safety profile, leading to potenti…
www.sciencedirect.com
August 14, 2025 at 10:06 AM
🚨New paper alert! We studied the long-term consequences of SSRI use during pregnancy on the offspring in rats in a seminatural environment. We found that perinatal FLX exposure significantly increases sexual behavior in adult male rats.
@uitnorgesarktiske.bsky.social
#neuroscience #neuroskyence
@uitnorgesarktiske.bsky.social
#neuroscience #neuroskyence
Reposted by Ole Christian Sylte
And for me the big question is: What about representational drift? 😄
Manifolds can be mapped, but individual neuronal responses change. That’s neat, but how does it make sense?
How can perception stay stable if the neurons keep changing?
I’m sure manifolds will help us understand that too…
🧠🧪
3/3
Manifolds can be mapped, but individual neuronal responses change. That’s neat, but how does it make sense?
How can perception stay stable if the neurons keep changing?
I’m sure manifolds will help us understand that too…
🧠🧪
3/3
August 4, 2025 at 7:27 PM
And for me the big question is: What about representational drift? 😄
Manifolds can be mapped, but individual neuronal responses change. That’s neat, but how does it make sense?
How can perception stay stable if the neurons keep changing?
I’m sure manifolds will help us understand that too…
🧠🧪
3/3
Manifolds can be mapped, but individual neuronal responses change. That’s neat, but how does it make sense?
How can perception stay stable if the neurons keep changing?
I’m sure manifolds will help us understand that too…
🧠🧪
3/3
Reposted by Ole Christian Sylte
🚨 New Article Alert! 🚨
Our latest research reveals how long-term consumption of a cafeteria (CAF) diet impacts the ventral tegmental area in rats. 🍔🍟🍩#Neuroskyence @uitnorgesarktiske.bsky.social www.sciencedirect.com/science/arti...
Our latest research reveals how long-term consumption of a cafeteria (CAF) diet impacts the ventral tegmental area in rats. 🍔🍟🍩#Neuroskyence @uitnorgesarktiske.bsky.social www.sciencedirect.com/science/arti...
Behavioral and neural alterations of the ventral tegmental area by exposure to junk food in rats
The brain reward system is essential for regulating appetitive and consummatory behaviors in response to various incentive stimuli. Junk food, charact…
www.sciencedirect.com
July 7, 2025 at 11:27 AM
🚨 New Article Alert! 🚨
Our latest research reveals how long-term consumption of a cafeteria (CAF) diet impacts the ventral tegmental area in rats. 🍔🍟🍩#Neuroskyence @uitnorgesarktiske.bsky.social www.sciencedirect.com/science/arti...
Our latest research reveals how long-term consumption of a cafeteria (CAF) diet impacts the ventral tegmental area in rats. 🍔🍟🍩#Neuroskyence @uitnorgesarktiske.bsky.social www.sciencedirect.com/science/arti...
Reposted by Ole Christian Sylte
New preprint alert! Perinatal fluoxetine exposure increases male rat sexual behavior. @uitnorgesarktiske.bsky.social #neuroscience #neuroskyence
Perinatal fluoxetine exposure increases male rat sexual behavior https://www.biorxiv.org/content/10.1101/2025.05.26.656113v1
May 31, 2025 at 3:14 PM
New preprint alert! Perinatal fluoxetine exposure increases male rat sexual behavior. @uitnorgesarktiske.bsky.social #neuroscience #neuroskyence
Reposted by Ole Christian Sylte
A non-value-based system in the brain automates decision-making and frees up cognitive resources for other tasks, a new study in mice suggests.
By Holly Barker
#neuroskyence
www.thetransmitter.org/neurobiology...
By Holly Barker
#neuroskyence
www.thetransmitter.org/neurobiology...
Dopamine neurons signal default behavior to reinforce habits
Movement-sensing neurons in the striatum influence a mouse’s choice of action by favoring routine behaviors.
www.thetransmitter.org
June 11, 2025 at 2:26 PM
A non-value-based system in the brain automates decision-making and frees up cognitive resources for other tasks, a new study in mice suggests.
By Holly Barker
#neuroskyence
www.thetransmitter.org/neurobiology...
By Holly Barker
#neuroskyence
www.thetransmitter.org/neurobiology...
Reposted by Ole Christian Sylte
A new paper from the group is online: we show that longterm low-frequency stimulation alleviates seizures beyond stimulation periods and reverses epilepsy-associated synaptic alterations. #TrEPILab
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice
Mesial temporal lobe epilepsy (MTLE) is a prevalent form of focal epilepsy characterized by seizures originating from the hippocampus and adjacent reg…
www.sciencedirect.com
May 20, 2025 at 1:02 PM
A new paper from the group is online: we show that longterm low-frequency stimulation alleviates seizures beyond stimulation periods and reverses epilepsy-associated synaptic alterations. #TrEPILab
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Ole Christian Sylte
Looking forward to an exciting Spring Hippocampal Research Conference in Verona with @mbartos.bsky.social @olechsylte.bsky.social @federicotorelli.bsky.social and @ute-fr.bsky.social
May 18, 2025 at 9:59 AM
Looking forward to an exciting Spring Hippocampal Research Conference in Verona with @mbartos.bsky.social @olechsylte.bsky.social @federicotorelli.bsky.social and @ute-fr.bsky.social
Reposted by Ole Christian Sylte
Impressive study in @nature from my colleague Marcus Stephenson-Jones at UCL in the @sainsburywellcome.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dopaminergic action prediction errors serve as a value-free teaching signal - Nature
Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
www.nature.com
May 15, 2025 at 9:47 AM
Impressive study in @nature from my colleague Marcus Stephenson-Jones at UCL in the @sainsburywellcome.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ole Christian Sylte
Read the full paper ‘Dopaminergic action prediction errors serve as a value-free teaching signal’ in @natureportfolio.nature.com
@gatsbyucl.bsky.social @imperialcollegeldn.bsky.social
www.nature.com/articles/s41...
@gatsbyucl.bsky.social @imperialcollegeldn.bsky.social
www.nature.com/articles/s41...
Dopaminergic action prediction errors serve as a value-free teaching signal - Nature
Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
www.nature.com
May 14, 2025 at 3:09 PM
Read the full paper ‘Dopaminergic action prediction errors serve as a value-free teaching signal’ in @natureportfolio.nature.com
@gatsbyucl.bsky.social @imperialcollegeldn.bsky.social
www.nature.com/articles/s41...
@gatsbyucl.bsky.social @imperialcollegeldn.bsky.social
www.nature.com/articles/s41...
Reposted by Ole Christian Sylte
Congrats to Aurore Gazala for winning the Eve Marder Best Paper Prize for “Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice” (Nat Comm, 2024) - awarded in person by Eve Marder at the IN-CODE retreat in Potsdam! @acazala.bsky.social #interneurons
April 30, 2025 at 9:48 AM
Congrats to Aurore Gazala for winning the Eve Marder Best Paper Prize for “Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice” (Nat Comm, 2024) - awarded in person by Eve Marder at the IN-CODE retreat in Potsdam! @acazala.bsky.social #interneurons
Reposted by Ole Christian Sylte
Play the "IBNS 2025 Reindeer Games Contest"! Share one of the reindeer adds on social media and get the most likes! @ibnsconnect.bsky.social
1st prize - $100 Gift Card or $200 off IBNS Registration
2nd prize - Free one year IBNS regular membership or two years Student/Postdoc membership
1st prize - $100 Gift Card or $200 off IBNS Registration
2nd prize - Free one year IBNS regular membership or two years Student/Postdoc membership
April 25, 2025 at 8:33 AM
Play the "IBNS 2025 Reindeer Games Contest"! Share one of the reindeer adds on social media and get the most likes! @ibnsconnect.bsky.social
1st prize - $100 Gift Card or $200 off IBNS Registration
2nd prize - Free one year IBNS regular membership or two years Student/Postdoc membership
1st prize - $100 Gift Card or $200 off IBNS Registration
2nd prize - Free one year IBNS regular membership or two years Student/Postdoc membership
Don't miss your last chance to attend IBNS in Tromsø!
What about visiting a neuroscience conference in Europe this year? There is still time to register for IBNS in Tromsø (June 24th-29th 2025)! Please like and share! For more information: www.ibnsconnect.org/annual-meeting @ibnsconnect.bsky.social #neuroskyence
April 25, 2025 at 11:16 AM
Don't miss your last chance to attend IBNS in Tromsø!
Reposted by Ole Christian Sylte
🔬🤝🎨
Drawing over my 2photon recordings of axons in the dentate gyrus for our last picture contest ✨️
Drawing over my 2photon recordings of axons in the dentate gyrus for our last picture contest ✨️
April 17, 2025 at 2:22 PM
🔬🤝🎨
Drawing over my 2photon recordings of axons in the dentate gyrus for our last picture contest ✨️
Drawing over my 2photon recordings of axons in the dentate gyrus for our last picture contest ✨️
Reposted by Ole Christian Sylte
Check our new manuscript on ‚Coordinated representational drift supports stable place coding in the hippocampal CA1’
by Ole Sylte, Antje Kilias, Marlene Bartos and Jonas Sauer.
www.biorxiv.org/content/10.1...
by Ole Sylte, Antje Kilias, Marlene Bartos and Jonas Sauer.
www.biorxiv.org/content/10.1...
Coordinated representational drift supports stable place coding in hippocampal CA1
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...
www.biorxiv.org
March 12, 2025 at 4:05 PM
Check our new manuscript on ‚Coordinated representational drift supports stable place coding in the hippocampal CA1’
by Ole Sylte, Antje Kilias, Marlene Bartos and Jonas Sauer.
www.biorxiv.org/content/10.1...
by Ole Sylte, Antje Kilias, Marlene Bartos and Jonas Sauer.
www.biorxiv.org/content/10.1...
Reposted by Ole Christian Sylte
New paper out! We found functional neuron classes in the mPFC with different spatial tuning properties (generalised vs. trajectory-specific) and distinct contribution to the encoding of task space. Great job by the first author Hannah!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Conjoint generalized and trajectory-specific coding of task structure by prefrontal neurons
Neurons in the medial prefrontal cortex (mPFC) show spatially modulated activities.
Muysers et al. show that mPFC neurons fall into distinct functional classes that differ
in terms of their spatial tu...
www.cell.com
March 11, 2025 at 10:47 AM
New paper out! We found functional neuron classes in the mPFC with different spatial tuning properties (generalised vs. trajectory-specific) and distinct contribution to the encoding of task space. Great job by the first author Hannah!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Ole Christian Sylte
New from the lab!! 👉🏼 authors.elsevier.com/a/1kgT43BtfH... 📝 @cellpress.bsky.social We discovered that genetically-defined neuron types in the hippocampus form unique manifolds! Dual color imaging, chemogenetics and topological analysis all at once! With Juan Gallego @juangallego.bsky.social
February 26, 2025 at 4:16 PM
New from the lab!! 👉🏼 authors.elsevier.com/a/1kgT43BtfH... 📝 @cellpress.bsky.social We discovered that genetically-defined neuron types in the hippocampus form unique manifolds! Dual color imaging, chemogenetics and topological analysis all at once! With Juan Gallego @juangallego.bsky.social
Reposted by Ole Christian Sylte
Slow life as a scientist
February 23, 2025 at 7:42 PM
Slow life as a scientist
Reposted by Ole Christian Sylte
First preprint from our lab! An @jerlich.bsky.social collaboration
We developed novel frameworks to study multi-agent decisions in mice.
Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!
www.biorxiv.org/content/10.1...
We developed novel frameworks to study multi-agent decisions in mice.
Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!
www.biorxiv.org/content/10.1...
Mice dynamically adapt to opponents in competitive multi-player games
Competing for resources in dynamic social environments is fundamental for survival, and requires continuous monitoring of both 'self' and 'others' to guide effective choices. Yet our understanding of ...
www.biorxiv.org
February 16, 2025 at 10:19 PM
First preprint from our lab! An @jerlich.bsky.social collaboration
We developed novel frameworks to study multi-agent decisions in mice.
Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!
www.biorxiv.org/content/10.1...
We developed novel frameworks to study multi-agent decisions in mice.
Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!
www.biorxiv.org/content/10.1...
Don't miss the chance to present at the world's northernmost university city while catching the midnight sun 👇
🚨 Reminder 🚨
📅 Submit your abstract by February 21, 2025!
Don’t miss your chance to be part of IBNS 2025 in Tromso, Norway!
👉More Details>> iibnsconnect.org/meetings
📅 Submit your abstract by February 21, 2025!
Don’t miss your chance to be part of IBNS 2025 in Tromso, Norway!
👉More Details>> iibnsconnect.org/meetings
February 10, 2025 at 10:38 AM
Don't miss the chance to present at the world's northernmost university city while catching the midnight sun 👇
Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics.
New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇
New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇
Coordinated representational drift supports stable place coding in hippocampal CA1
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...
www.biorxiv.org
February 5, 2025 at 9:09 AM
Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics.
New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇
New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇
Reposted by Ole Christian Sylte
New paper alert! We studied the temporal copulatory patterns of female rat sexual behavior and proposed a new behavioral assessment method. #behavioralneuroscience #UiTtheArcticUniversityofNorway #neuroscience
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The temporal copulatory patterns of female rat sexual behavior
Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulatin…
www.sciencedirect.com
January 22, 2025 at 8:46 AM
New paper alert! We studied the temporal copulatory patterns of female rat sexual behavior and proposed a new behavioral assessment method. #behavioralneuroscience #UiTtheArcticUniversityofNorway #neuroscience
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Ole Christian Sylte
Our new preprint on long-term low-frequency stimulation in MTLE is online. We show that LFS has lasting effects on seizures even during stimulation-free periods and induces ultrastructural changes at the PP synapse.
Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice https://www.biorxiv.org/content/10.1101/2025.01.16.633322v1
January 20, 2025 at 10:07 AM
Our new preprint on long-term low-frequency stimulation in MTLE is online. We show that LFS has lasting effects on seizures even during stimulation-free periods and induces ultrastructural changes at the PP synapse.