Chunyu Ann Duan
@annduan.bsky.social
Neural mechanisms of decision-making, Group Leader at Sainsbury Wellcome Centre, UCL. Simons Global Brain postdoc alum, Princeton Neuro alum. sainsburywellcome.org/web/groups/duan-lab
Pinned
Chunyu Ann Duan
@annduan.bsky.social
· Dec 14
A frontal motor circuit for economic decisions and actions
Flexible behaviour requires transforming abstract cognitive representations, such as value preferences, into concrete motor actions. During economic decision-making, individuals evaluate options to gu...
www.biorxiv.org
New preprint from the lab!
A frontal motor circuit for economic decisions and actions:
www.biorxiv.org/content/10.6...
We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.
A frontal motor circuit for economic decisions and actions:
www.biorxiv.org/content/10.6...
We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.
Reposted by Chunyu Ann Duan
We’re hiring a Group Leader!
Join us to lead a transformative initiative in human systems neuroscience.
Find out more and apply ⤵️
www.sainsburywellcome.org/content/curr...
Join us to lead a transformative initiative in human systems neuroscience.
Find out more and apply ⤵️
www.sainsburywellcome.org/content/curr...
February 13, 2026 at 1:41 PM
We’re hiring a Group Leader!
Join us to lead a transformative initiative in human systems neuroscience.
Find out more and apply ⤵️
www.sainsburywellcome.org/content/curr...
Join us to lead a transformative initiative in human systems neuroscience.
Find out more and apply ⤵️
www.sainsburywellcome.org/content/curr...
Reposted by Chunyu Ann Duan
Let's talk about "grumpy lab person". Many labs have them. With an eye to keeping science at its most rigorous, they cross the line into criticism that's too harsh. They are the ones who risk killing your scientific spirit. They are reviewer 2. /1
January 21, 2026 at 8:36 AM
Let's talk about "grumpy lab person". Many labs have them. With an eye to keeping science at its most rigorous, they cross the line into criticism that's too harsh. They are the ones who risk killing your scientific spirit. They are reviewer 2. /1
Reposted by Chunyu Ann Duan
Bichan Wu (@bichanw.bsky.social) & I wrote a tutorial paper on Reduced Rank Regression (RRR) — the statistical method underlying "communication subspaces" from Semedo et al 2019 — aimed at neuroscientists.
arxiv.org/abs/2512.12467
arxiv.org/abs/2512.12467
Reduced rank regression for neural communication: a tutorial for neuroscientists
Reduced rank regression (RRR) is a statistical method for finding a low-dimensional linear mapping between a set of high-dimensional inputs and outputs. In recent years, RRR has found numerous applica...
arxiv.org
December 17, 2025 at 2:06 AM
Bichan Wu (@bichanw.bsky.social) & I wrote a tutorial paper on Reduced Rank Regression (RRR) — the statistical method underlying "communication subspaces" from Semedo et al 2019 — aimed at neuroscientists.
arxiv.org/abs/2512.12467
arxiv.org/abs/2512.12467
Happy holidays from the Duan Lab!
We celebrated with some delicious and spicy Thai food :)
We celebrated with some delicious and spicy Thai food :)
December 16, 2025 at 9:45 PM
Happy holidays from the Duan Lab!
We celebrated with some delicious and spicy Thai food :)
We celebrated with some delicious and spicy Thai food :)
Reposted by Chunyu Ann Duan
New ms on trinary choices! Somewhat surprisingly, our monkeys’ choices satisfied IIA (independence of irrelevant alternatives). In OFC, decision variables were represented in the same way under trinary and under binary choices. This property implies IIA.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk
Economic choice entails computing and comparing the subjective values of different goods. Orbitofrontal cortex (OFC) is thought to contribute to both operations. However, previous work focused almost ...
www.biorxiv.org
September 21, 2025 at 10:36 PM
New ms on trinary choices! Somewhat surprisingly, our monkeys’ choices satisfied IIA (independence of irrelevant alternatives). In OFC, decision variables were represented in the same way under trinary and under binary choices. This property implies IIA.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New preprint from the lab!
A frontal motor circuit for economic decisions and actions:
www.biorxiv.org/content/10.6...
We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.
A frontal motor circuit for economic decisions and actions:
www.biorxiv.org/content/10.6...
We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.
A frontal motor circuit for economic decisions and actions
Flexible behaviour requires transforming abstract cognitive representations, such as value preferences, into concrete motor actions. During economic decision-making, individuals evaluate options to gu...
www.biorxiv.org
December 14, 2025 at 10:59 AM
New preprint from the lab!
A frontal motor circuit for economic decisions and actions:
www.biorxiv.org/content/10.6...
We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.
A frontal motor circuit for economic decisions and actions:
www.biorxiv.org/content/10.6...
We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.
Reposted by Chunyu Ann Duan
Going to #Cosyne2025? Check out our researchers’ posters and talks:
www.sainsburywellcome.org/web/content/...
@cosynemeeting.bsky.social
www.sainsburywellcome.org/web/content/...
@cosynemeeting.bsky.social
March 26, 2025 at 9:12 AM
Going to #Cosyne2025? Check out our researchers’ posters and talks:
www.sainsburywellcome.org/web/content/...
@cosynemeeting.bsky.social
www.sainsburywellcome.org/web/content/...
@cosynemeeting.bsky.social
First preprint from our lab! An @jerlich.bsky.social collaboration
We developed novel frameworks to study multi-agent decisions in mice.
Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!
www.biorxiv.org/content/10.1...
We developed novel frameworks to study multi-agent decisions in mice.
Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!
www.biorxiv.org/content/10.1...
Mice dynamically adapt to opponents in competitive multi-player games
Competing for resources in dynamic social environments is fundamental for survival, and requires continuous monitoring of both 'self' and 'others' to guide effective choices. Yet our understanding of ...
www.biorxiv.org
February 16, 2025 at 10:19 PM
First preprint from our lab! An @jerlich.bsky.social collaboration
We developed novel frameworks to study multi-agent decisions in mice.
Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!
www.biorxiv.org/content/10.1...
We developed novel frameworks to study multi-agent decisions in mice.
Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!
www.biorxiv.org/content/10.1...