Events celebrating women in electron microscopy are rare, which made my recent experience at the Ernst Ruska-Centre (ER-C), Forschungszentrum Jülich, Germany, truly special. I had the privilege of not only attending but also serving as a young keynote speaker at this inspiring gathering. 🎉

Curious to know how does auxiliary subunit Neto2 modulate kainate receptor (KAR) function? Read our latest study describing GluK2-Neto2 complex-captured in both its activated and true apo states.

www.nature.com/articles/s41...

Check out our new study revealing how yeast cells regulate oxidative stress.

Our latest preprint on peroxisomal fatty-acid transport is live!!

@ohsunews.bsky.social #OHSU @uofcalifornia.bsky.social #UCSF

Congratulations to all the co-authors-
🙌 🎉 🥳
@nkhandelwal.bsky.social, Devin J Seka, Sree G Balasubramani, Miles S Dickinson, Alexander Myasnikov, @igech.bsky.social, Robert M Stroud.

I'm excited to share our lab's newest publication on the structure and pharmacology of human GABA transporter 3 @natcomms.nature.com. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. 💊 🧪 #CryoEM #OpenAccess rdcu.be/ei2KY

🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo

Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection.

www.sciencedirect.com/science/arti...

#CryoSPARC v4.7 is out! 🚀 
Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more!
Full changelog: cryosparc.com/updates

#cryoEM

Our paper on " Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A" is published in Nature Communications 🥂 🎊

www.nature.com/articles/s41...

I am super excited to share that my work at @yifan_ucsf has just been published in Nature🎉 From developing pYC KI system, it was a long journey to understand endogenous protein dynamics. I appreciate the support from FASN team! 🕺Let's dive into the endogenous & dynamic protein world🏊🏄🚣

Coot 1.1.14 has been released!

Coming to homebrew and flatpak soon!

- Clark & Labute comes to Coot 1, Moorhen & chapi!
(svg, 2D ligand environment view)
- Solid Symmetry (symmetry that you can see!)
- PAE plot for AlphaFold models
#coot
#molmatinf

ChimeraX can be used to find pockets and cavities in protein structures using the Find Cavities tool or kvfinder command. This feature is available in daily builds from 10 March 2025 or later.

#NIHFundedDiscovery

How do cells avoid the "kiss of death"?

Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage.

#CryoEM reveals the molecular switches behind this process!

www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...

I am happy to share my new publication in PNAS entitled “Structural basis of disease mutation and substrate recognition by the human SLC2A9 transporter” (www.pnas.org/doi/full/10....).

Our paper "Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica" is published in Science Advances today 🥂 🎊

tinyurl.com/MGuptaSA

Huge congratulations to the team- @nkhandelwal.bsky.social, Andrew Nelson, Peter Hwang, Sergei Pourmal, Jeffrey Bennett, ROBERT M STROUD!