Shanti Gangwar
@shantigangwar.bsky.social
Cryo-EM, Ion Channels, iGluRs, Synapse, Columbia Univeristy
Our latest review on kainate receptors, a subtype of neurotransmitter receptors, providing an up-to-date and comprehensive overview of their structural features and gating mechanisms. @sobolevsky.bsky.social
Happy to share our new review of kainate receptor structure and gating. www.frontiersin.org/journals/pha...
October 22, 2025 at 4:35 PM
Our latest review on kainate receptors, a subtype of neurotransmitter receptors, providing an up-to-date and comprehensive overview of their structural features and gating mechanisms. @sobolevsky.bsky.social
Reposted by Shanti Gangwar
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 12:05 AM
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
Curious to know how does auxiliary subunit Neto2 modulate kainate receptor (KAR) function? Read our latest study describing GluK2-Neto2 complex-captured in both its activated and true apo states.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Activation of kainate receptor GluK2–Neto2 complex - Nature Structural & Molecular Biology
Gangwar et al. present cryo-electron microscopy structures of GluK2 kainate receptors with auxiliary subunit Neto2 and reveal the basis of receptor activation.
www.nature.com
August 22, 2025 at 7:36 PM
Curious to know how does auxiliary subunit Neto2 modulate kainate receptor (KAR) function? Read our latest study describing GluK2-Neto2 complex-captured in both its activated and true apo states.
www.nature.com/articles/s41...
www.nature.com/articles/s41...