Nick van Gastel
@nickvangastel.bsky.social
Assistant Prof at UCLouvain, FNRS Research Associate, WELBIO Investigator and Group Leader at de Duve Institute, studying metabolism and microenvironment in hematopoiesis and leukemia.
https://www.deduveinstitute.be/research-group/nick-van-gastel
https://www.deduveinstitute.be/research-group/nick-van-gastel
Reposted by Nick van Gastel
The November Issue of #ExpHem is here! Explore the lineup, including Honoring giants in hematopoietic and progenitor cell biology www.exphem.org/article/S030...
November 19, 2025 at 10:15 PM
The November Issue of #ExpHem is here! Explore the lineup, including Honoring giants in hematopoietic and progenitor cell biology www.exphem.org/article/S030...
Reposted by Nick van Gastel
Heme biosynthesis is a really fascinating pathway. We think targeting the enzymes that make heme is a really promising strategy for AML. Check out our paper online today in @cellpress.bsky.social @petermaccc.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
Reduced levels of the essential metabolite heme are a common feature of acute myeloid
leukemia, and consequently, leukemic cells are highly sensitive to inhibition of de
novo heme synthesis. Blockade ...
www.cell.com
November 20, 2025 at 6:07 AM
Heme biosynthesis is a really fascinating pathway. We think targeting the enzymes that make heme is a really promising strategy for AML. Check out our paper online today in @cellpress.bsky.social @petermaccc.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Nick van Gastel
Absolutely! Their work changed the field of experimental hematology forever. Learn more about their legacy in these tributes: www.exphem.org/article/S030... #ExpHem
November 17, 2025 at 10:39 PM
Absolutely! Their work changed the field of experimental hematology forever. Learn more about their legacy in these tributes: www.exphem.org/article/S030... #ExpHem
Reposted by Nick van Gastel
📢ATTENTION BSKY COMMUNITY - We are expanding!! If you are interested in studying metabolic drivers of cancer progression and therapy resistance using bioengineered models consider joining our group at the Moffitt! Pl. repost, tks
moffitt-cancer-center-careers.hctsportals.com/jobs/2115134...
moffitt-cancer-center-careers.hctsportals.com/jobs/2115134...
Postdoctoral Fellow – Focus on Metabolic Regulators of Cancer Epigenetics in Tampa, FL - Moffitt Cancer Center CareersPostdoctoral Fellow – Focus on Metabolic Regulators of Cancer Epigenetics in Tampa...
Working at Moffitt Cancer Center is both a career and a mission. All employees are dedicated to patient care, research and education to advance our fight against this disease.
moffitt-cancer-center-careers.hctsportals.com
November 17, 2025 at 11:39 PM
📢ATTENTION BSKY COMMUNITY - We are expanding!! If you are interested in studying metabolic drivers of cancer progression and therapy resistance using bioengineered models consider joining our group at the Moffitt! Pl. repost, tks
moffitt-cancer-center-careers.hctsportals.com/jobs/2115134...
moffitt-cancer-center-careers.hctsportals.com/jobs/2115134...
Reposted by Nick van Gastel
Showcase your research in Experimental Hematology, the ISEH journal dedicated to transformative hematology science. Take advantage of fast-track options, open access discounts, and global visibility for your work. Learn more: iseh.org/Publications/ExpHem-Journal
ExpHem Journal
Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on…
iseh.org
November 17, 2025 at 10:30 PM
Showcase your research in Experimental Hematology, the ISEH journal dedicated to transformative hematology science. Take advantage of fast-track options, open access discounts, and global visibility for your work. Learn more: iseh.org/Publications/ExpHem-Journal
Reposted by Nick van Gastel
Join or renew your ISEH membership now for 2026! Stay connected to your society with webinars, networking, awards eligibility, and meeting discounts.
🔗 iseh.org/membership
🔗 iseh.org/membership
November 18, 2025 at 4:30 PM
Join or renew your ISEH membership now for 2026! Stay connected to your society with webinars, networking, awards eligibility, and meeting discounts.
🔗 iseh.org/membership
🔗 iseh.org/membership
Reposted by Nick van Gastel
Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies for thymus regeneration #NBTNV go.nature.com/4r1A8Vp
rdcu.be/eOpTg
rdcu.be/eOpTg
Mesenchymal cells rebuild the thymus - Nature Biotechnology
Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies for thymus regeneration.
go.nature.com
November 13, 2025 at 5:05 AM
Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies for thymus regeneration #NBTNV go.nature.com/4r1A8Vp
rdcu.be/eOpTg
rdcu.be/eOpTg
Reposted by Nick van Gastel
Everyone talks about thymic epithelial cells when it comes to T cell development. They play a major role — just not the only one. Our new paper in @natbiotech.nature.com shows the mesenchyme has been quietly pulling strings: rdcu.be/eNF24
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity
Nature Biotechnology - T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function.
rdcu.be
October 31, 2025 at 2:19 PM
Everyone talks about thymic epithelial cells when it comes to T cell development. They play a major role — just not the only one. Our new paper in @natbiotech.nature.com shows the mesenchyme has been quietly pulling strings: rdcu.be/eNF24
Reposted by Nick van Gastel
Extremely useful for spectral flow cytometry enthusiasts- thanks @labliston.bsky.social I will share with our core too
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 3:22 PM
Extremely useful for spectral flow cytometry enthusiasts- thanks @labliston.bsky.social I will share with our core too
Reposted by Nick van Gastel
The Board of Directors call for nominations is open until 13 November. Influence the direction of ISEH and nominate yourself or a colleague! More info on www.iseh.org
October 22, 2025 at 4:54 PM
The Board of Directors call for nominations is open until 13 November. Influence the direction of ISEH and nominate yourself or a colleague! More info on www.iseh.org
Reposted by Nick van Gastel
For my lab lead friends, check out this article of best practices from my colleagues and I on the ISEH Junior PI committee on organizing a leading your team. authors.elsevier.com/c/1lxZ~,6sio...
authors.elsevier.com
October 15, 2025 at 11:40 AM
For my lab lead friends, check out this article of best practices from my colleagues and I on the ISEH Junior PI committee on organizing a leading your team. authors.elsevier.com/c/1lxZ~,6sio...
Reposted by Nick van Gastel
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
October 13, 2025 at 8:47 PM
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Reposted by Nick van Gastel
There are ✌️ weeks left to register for the FREE 22 October webinar on Responsible AI in Research and Publishing featuringLaura Watts, PhD from @lumanity.bsky.social and @p4sc4l.substack.com from Wiley. Register here 👉 iseh.org/Webinars-Eve...
October 8, 2025 at 3:31 PM
There are ✌️ weeks left to register for the FREE 22 October webinar on Responsible AI in Research and Publishing featuringLaura Watts, PhD from @lumanity.bsky.social and @p4sc4l.substack.com from Wiley. Register here 👉 iseh.org/Webinars-Eve...
Reposted by Nick van Gastel
Interested in understanding AI better and best practices for using it in research? Don't forget to register for our @isehsociety.bsky.social webinar happening 10/22 @ 9am ET to learn how to use AI responsibly and effectively! iseh.org/Webinars-Eve...
Webinars
iseh.org
October 8, 2025 at 3:46 PM
Interested in understanding AI better and best practices for using it in research? Don't forget to register for our @isehsociety.bsky.social webinar happening 10/22 @ 9am ET to learn how to use AI responsibly and effectively! iseh.org/Webinars-Eve...
Reposted by Nick van Gastel
Surprising finding that standard chemo renders AML resistant to subsequent treatment with menin inhibitors. Published in @isehsociety.bsky.social journal Exp. Hem.: www.exphem.org/article/S030...
Upfront Menin-inhibitor resistance in multiply pretreated leukemias
10% of acute leukemias carry rearrangements of the KMT2A gene (Mixed-Lineage Leukemia-1,
MLL-1). More than 80 fusion partners have been identified, and differences in fusion
partner have been linked t...
www.exphem.org
September 30, 2025 at 5:51 PM
Surprising finding that standard chemo renders AML resistant to subsequent treatment with menin inhibitors. Published in @isehsociety.bsky.social journal Exp. Hem.: www.exphem.org/article/S030...
After a stop in Osaka I’m on my way home after #ISEH2025! This was a very successful edition for the MEMI Lab, with 4 posters presented and 2 awards received (@isehsociety.bsky.social New Investigator Award for @celinanielsen.bsky.social and Service Award for myself)! See you in Frankfurt in 2026!
September 30, 2025 at 9:14 AM
After a stop in Osaka I’m on my way home after #ISEH2025! This was a very successful edition for the MEMI Lab, with 4 posters presented and 2 awards received (@isehsociety.bsky.social New Investigator Award for @celinanielsen.bsky.social and Service Award for myself)! See you in Frankfurt in 2026!
Reposted by Nick van Gastel
Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Rapid epigenomic classification of acute leukemia - Nature Genetics
The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.
www.nature.com
September 22, 2025 at 8:41 PM
Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
So proud of this work by the @isehsociety.bsky.social Junior Faculty Committee!!! Whether you are just starting your lab or had it for many years, a good Lab Handbook is essential, and we want to help you on the way with this important document…
Are you a PI who just set up your lab or wants a more efficient daily flow? @isehsociety.bsky.social Junior Faculty Committee (and more) share in #ExpHem to help you build a transparent and functional lab culture. See how a Lab Handbook can benefit you. @nickvangastel.bsky.social bit.ly/3KBFvcQ
September 26, 2025 at 7:00 AM
So proud of this work by the @isehsociety.bsky.social Junior Faculty Committee!!! Whether you are just starting your lab or had it for many years, a good Lab Handbook is essential, and we want to help you on the way with this important document…
Reposted by Nick van Gastel
Are you a PI who just set up your lab or wants a more efficient daily flow? @isehsociety.bsky.social Junior Faculty Committee (and more) share in #ExpHem to help you build a transparent and functional lab culture. See how a Lab Handbook can benefit you. @nickvangastel.bsky.social bit.ly/3KBFvcQ
September 25, 2025 at 8:19 PM
Are you a PI who just set up your lab or wants a more efficient daily flow? @isehsociety.bsky.social Junior Faculty Committee (and more) share in #ExpHem to help you build a transparent and functional lab culture. See how a Lab Handbook can benefit you. @nickvangastel.bsky.social bit.ly/3KBFvcQ
Reposted by Nick van Gastel
Don't miss out on this opportunity to ask your burning questions to leading experts in the field! #ISEH2025
A few tickets left for the #ISEH2025 meet the expert breakfast. Only $35 dollars each! @isehsociety.bsky.social
September 25, 2025 at 7:52 AM
Don't miss out on this opportunity to ask your burning questions to leading experts in the field! #ISEH2025
Reposted by Nick van Gastel
A few tickets left for the #ISEH2025 meet the expert breakfast. Only $35 dollars each! @isehsociety.bsky.social
September 25, 2025 at 7:23 AM
A few tickets left for the #ISEH2025 meet the expert breakfast. Only $35 dollars each! @isehsociety.bsky.social
Reposted by Nick van Gastel
Excited for tonight's poster session at #ISEH2025 where I will present my latest work on BM secretome remodeling during aging - catch me at poster 3003 if you want to know more! @isehsociety.bsky.social
September 25, 2025 at 5:05 AM
Excited for tonight's poster session at #ISEH2025 where I will present my latest work on BM secretome remodeling during aging - catch me at poster 3003 if you want to know more! @isehsociety.bsky.social
Reposted by Nick van Gastel
#ISEH2025 Two posters from our lab tonight at the poster session:
#3171 by Célia Sergi showing how metabolic reprogramming in the niche is required for emergency myelopoiesis during infection!
#3113 by myself on how protein palmitoylation controls metabolic flexibility in AML!
#3171 by Célia Sergi showing how metabolic reprogramming in the niche is required for emergency myelopoiesis during infection!
#3113 by myself on how protein palmitoylation controls metabolic flexibility in AML!
September 25, 2025 at 6:42 AM
#ISEH2025 Two posters from our lab tonight at the poster session:
#3171 by Célia Sergi showing how metabolic reprogramming in the niche is required for emergency myelopoiesis during infection!
#3113 by myself on how protein palmitoylation controls metabolic flexibility in AML!
#3171 by Célia Sergi showing how metabolic reprogramming in the niche is required for emergency myelopoiesis during infection!
#3113 by myself on how protein palmitoylation controls metabolic flexibility in AML!
#ISEH2025 Two posters from our lab tonight at the poster session:
#3171 by Célia Sergi showing how metabolic reprogramming in the niche is required for emergency myelopoiesis during infection!
#3113 by myself on how protein palmitoylation controls metabolic flexibility in AML!
#3171 by Célia Sergi showing how metabolic reprogramming in the niche is required for emergency myelopoiesis during infection!
#3113 by myself on how protein palmitoylation controls metabolic flexibility in AML!
September 25, 2025 at 6:42 AM
#ISEH2025 Two posters from our lab tonight at the poster session:
#3171 by Célia Sergi showing how metabolic reprogramming in the niche is required for emergency myelopoiesis during infection!
#3113 by myself on how protein palmitoylation controls metabolic flexibility in AML!
#3171 by Célia Sergi showing how metabolic reprogramming in the niche is required for emergency myelopoiesis during infection!
#3113 by myself on how protein palmitoylation controls metabolic flexibility in AML!