Nick Sapp
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nicksapp.bsky.social
Nick Sapp
@nicksapp.bsky.social
42 followers 230 following 2 posts
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Reposted by Nick Sapp
teiflab.bsky.social
Contributions of local structural and energetic features of DNA to large-scale genomic organization [perspective by Wilma Olson & Co) www.sciencedirect.com/science/arti...
Oscillatory pattern of chain extension and nucleosome self-association with variation in protein-free DNA linker length in simulated nucleosome-decorated DNA chains. Regular structures bearing 15 nucleosomes constructed from the mean rigid-body parameters between successive base pairs; nucleosomal cores depicted as wedge-shaped objects and color-coded to highlight the two- and three-start organization of the structures. Nucleosomal DNA constrained to the 147-bp pathway found in the best-resolved core particle structure, pdb_id 1kx5 Distortions in the average structures of simulated nucleosome-decorated DNA chains introduced by changes in the positioning of a singe nucleosome. A. Local opening and unpacking of a compact array introduced by a single 2-bp increment in the spacing between nucleosomes. B. Kinking of an extended array by a single 5-bp increment in nucleosome spacing. Effects of the nucleosomal DNA pathway on the average configurations of simulated 12-nucleosome arrays. Average structures bearing the undertwisted DNA found in the best-resolved core particle structure, pdb_id 1kx5, compared to the overtwisted DNA found in the RCC1-nucleosome complex, pdb_id 3mvd. The regulatory protein is not included in the simulations. Upper views looking perpendicular to the chromatin axis and lower views down the axis Molecular 'snapshots' illustrating the potential effects of chain length and nucleosome positioning on large-scale chromatin folding. A. Smoothly deformed array of 78 nucleosomes with uniform 177-bp spacing. B. 77-nucleosome chromatin 'copolymer' containing three stretches of nucleosomes with different spacings: a compact array of 26 nucleosomes (deep brown) with 172-bp spacing at the 5́-end of the chain; an extended array of 26 nucleosomes (light brown) with 177-bp spacing in the middle; an opened array of 25 nucleosomes (yellow) with 207-bp spacing and a nucleosome-free gap at the 3́-end of the chain. Note the more pronounced junction between ‘helical’ stretches when the spacing changes by roughly a half turn of DNA (172 – 177 = –5 bp) than when altered by a multiple of the double-helical repeat (207 – 177 = 30 bp). The presence of a nucleosome-free gap, within the stretch of nucleosomes spaced at 207-bp intervals, enhances the flexibility of the modeled structure, allowing the chain to bend in various directions
August 23, 2025 at 11:33 AM
Reposted by Nick Sapp
masaashimazoe.bsky.social
Euchromatin is mostly condensed⁉️

With @shiori-iida.bsky.social , We revealed the detailed structure of euchromatin using super-resolution imaging.

Cohesin regulates the function of euchromatin via chromatin dynamics!
(1/n)
kazu-maeshima.bsky.social Kazuhiro Maeshima @kazu-maeshima.bsky.social · Aug 28
Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...
August 28, 2025 at 8:43 AM
Reposted by Nick Sapp
alongcamepoly4thew.bsky.social
TAYLOR!

TOWNSEND!

#USOPEN
🎾💥💥💥💥
August 27, 2025 at 10:23 PM
nicksapp.bsky.social
I second this 🙋🏾‍♂️
August 29, 2025 at 10:03 PM
Reposted by Nick Sapp
blackinbiophys.bsky.social
Hi everyone! It's Daniel and Eesha taking over for Jonesy lab at NYU!

Meet our wonderful PI, Jonesy, an RNA structure enthusiast 🧬

Be sure to check out our lab website :)
wp.nyu.edu/labjonesy/
May 29, 2025 at 4:01 PM
Reposted by Nick Sapp
drstarbird.bsky.social
An initiative led by brave graduate students and leaders to fight for science!
Stand up for Science March 7th flyer with more info at standupforscience2025.org
February 17, 2025 at 4:34 PM
Reposted by Nick Sapp
morgancarterphd.bsky.social
We are hiring two teaching professors at UNC Charlotte to teach Human Anat Phys and Gen Bio/Ecology!

Please consider applying - the teaching faculty in our department are awesome and Charlotte is a wonderful city to live in. 🧪 #AcademicSky #BioSky
jobs.charlotte.edu/postings/60049
Assistant Teaching Professor/Lecturer
The applicant will possess a M.S. or Ph.D. in an area of the Biological Sciences or related discipline, a demonstrated history of employing best practices in classroom pedagogy, and a strong commitmen...
jobs.charlotte.edu
November 21, 2024 at 1:01 PM
Reposted by Nick Sapp
olufemiotaiwo.bsky.social
our ancestors accomplished more, with less, against worse. stay locked in.
November 19, 2024 at 1:25 PM
Reposted by Nick Sapp
jay.bsky.team
Bluesky now has over 20M people!! 🎉

We've been adding over a million users per day for the last few days. To celebrate, here are 20 fun facts about Bluesky:
November 19, 2024 at 6:51 PM