Nicholas Gervais
@nickgervais.bsky.social
PhD candidate developing CRISPR-based technologies to study pathogenic fungi 🧬🇨🇦
Reposted by Nicholas Gervais
Preprint alert: the latest from my collaboration with the great @afloresmireles.bsky.social, @shapirorebecca.bsky.social , and Ilse Jacobsen (not in BS). You can find it here: www.biorxiv.org/content/10.1... A small thread below (1/3)
The Unique Efg1 Fungal Virulence Regulon in the Catheterized Bladder Environment
Urinary catheterization, a common procedure in hospitals and nursing home facilities, is a primary driver of hospital-acquired infections (HAI). These devices frequently lead to catheter-associated ur...
www.biorxiv.org
November 11, 2025 at 6:41 PM
Preprint alert: the latest from my collaboration with the great @afloresmireles.bsky.social, @shapirorebecca.bsky.social , and Ilse Jacobsen (not in BS). You can find it here: www.biorxiv.org/content/10.1... A small thread below (1/3)
Reposted by Nicholas Gervais
Excellent news - we desperately need more antifungal drugs. Onto the reading list this goes! #microsky 🧪
Nature research paper: A polyene macrolide targeting phospholipids in the fungal cell membrane ttps://www.nature.com/articles/s41586-025-08678-9
A polyene macrolide targeting phospholipids in the fungal cell membrane - Nature
Mandimycin, a polyene macrolide, exhibits strong antifungal activity and possesses a mode of action that is distinct from other compounds of this class.
go.nature.com
March 19, 2025 at 6:44 PM
Excellent news - we desperately need more antifungal drugs. Onto the reading list this goes! #microsky 🧪
Reposted by Nicholas Gervais
Since both believed to some extent in inheritance of acquired traits, the fundamental difference between Lamarck and Darwin (aside from mechanism, natural selection vs use and disuse) is that Lamarck believed in the power of Life and Darwin believed in the power of Death
March 17, 2025 at 10:00 AM
Since both believed to some extent in inheritance of acquired traits, the fundamental difference between Lamarck and Darwin (aside from mechanism, natural selection vs use and disuse) is that Lamarck believed in the power of Life and Darwin believed in the power of Death
Reposted by Nicholas Gervais
FDA approves new non-opioid pain drug tinyurl.com/3zxb6vrd
The FDA has approved Vertex’s suzetrigine, an oral inhibitor of the ion channel NaV1.8, for the treatment of moderate to severe acute pain, providing a much-needed new option. Read more about the history of the drug here tinyurl.com/5x7zyduj
The FDA has approved Vertex’s suzetrigine, an oral inhibitor of the ion channel NaV1.8, for the treatment of moderate to severe acute pain, providing a much-needed new option. Read more about the history of the drug here tinyurl.com/5x7zyduj
January 30, 2025 at 11:15 PM
FDA approves new non-opioid pain drug tinyurl.com/3zxb6vrd
The FDA has approved Vertex’s suzetrigine, an oral inhibitor of the ion channel NaV1.8, for the treatment of moderate to severe acute pain, providing a much-needed new option. Read more about the history of the drug here tinyurl.com/5x7zyduj
The FDA has approved Vertex’s suzetrigine, an oral inhibitor of the ion channel NaV1.8, for the treatment of moderate to severe acute pain, providing a much-needed new option. Read more about the history of the drug here tinyurl.com/5x7zyduj
Reposted by Nicholas Gervais
New pre-print!!! What types of genes end up on plasmids and why? The take home message of this paper is that beneficial genes move from plasmids to chromosome, causing the ecological value of plasmids to decay over time.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy
Plasmids are a ubiquitous feature of bacterial genomes, but the evolutionary forces driving genes to become associated with plasmids are poorly understood. To address this problem, we compared the fit...
www.biorxiv.org
January 24, 2025 at 11:10 PM
New pre-print!!! What types of genes end up on plasmids and why? The take home message of this paper is that beneficial genes move from plasmids to chromosome, causing the ecological value of plasmids to decay over time.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nicholas Gervais
Our global study on the state of trust in scientists is now out in Nature Human Behaviour! 🥳
With a team of 241 researchers, we surveyed 71,922 people in 68 countries, providing the largest dataset on trust in scientists post-pandemic 👇🧵https://www.nature.com/articles/s41562-024-02090-5
With a team of 241 researchers, we surveyed 71,922 people in 68 countries, providing the largest dataset on trust in scientists post-pandemic 👇🧵https://www.nature.com/articles/s41562-024-02090-5
January 20, 2025 at 10:16 AM
Our global study on the state of trust in scientists is now out in Nature Human Behaviour! 🥳
With a team of 241 researchers, we surveyed 71,922 people in 68 countries, providing the largest dataset on trust in scientists post-pandemic 👇🧵https://www.nature.com/articles/s41562-024-02090-5
With a team of 241 researchers, we surveyed 71,922 people in 68 countries, providing the largest dataset on trust in scientists post-pandemic 👇🧵https://www.nature.com/articles/s41562-024-02090-5
This is great. Hope this format makes its way to other Nature journals (and can be open-access...)
New online! Introducing ‘Ask an Expert’
Introducing ‘Ask an Expert’
Nature Reviews Earth & Environment, Published online: 14 January 2025; doi:10.1038/s43017-024-00641-yNature Reviews Earth & Environment is pleased to launch a new article type — Ask an Expert — that offers the public an opportunity to have their burning…
go.nature.com
January 15, 2025 at 5:57 PM
This is great. Hope this format makes its way to other Nature journals (and can be open-access...)
Reposted by Nicholas Gervais
What do bacterial cells do when they run out of nutrients? Although most bacterial studies focus on cells in exponentially growing states, in the wild bacteria likely spend most of their time slowly starving to death. 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
E. coli prepares for starvation by dramatically remodeling its proteome in the first hours after loss of nutrients
It is widely believed that due to nutrient limitations in natural environments, bacteria spend most of their life in non-growing states. However, very little is known about how bacteria change their p...
www.biorxiv.org
January 15, 2025 at 11:12 AM
What do bacterial cells do when they run out of nutrients? Although most bacterial studies focus on cells in exponentially growing states, in the wild bacteria likely spend most of their time slowly starving to death. 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nicholas Gervais
When I started my PhD 6 years ago, this sticker on my office door got me excited. Sure! let's "CRISPR Candida auris"! Today I am excited to show that that's not as easy as it sounds! 😉 Read our latest preprint on the challenges with editing C. auris: www.biorxiv.org/content/10.1...
January 10, 2025 at 4:10 PM
When I started my PhD 6 years ago, this sticker on my office door got me excited. Sure! let's "CRISPR Candida auris"! Today I am excited to show that that's not as easy as it sounds! 😉 Read our latest preprint on the challenges with editing C. auris: www.biorxiv.org/content/10.1...
Reposted by Nicholas Gervais
Happy New Year, blue-sci-peeps!
My piece in Annual Review of Biophysics on chromatin replication is now available online.
doi.org/10.1146/annu...
If you have paywall issues, try this link:
madhanilab.ucsf.edu/s/annurev-bi...
My piece in Annual Review of Biophysics on chromatin replication is now available online.
doi.org/10.1146/annu...
If you have paywall issues, try this link:
madhanilab.ucsf.edu/s/annurev-bi...
Mechanisms of Inheritance of Chromatin States: From Yeast to Human | Annual Reviews
In this article I review mechanisms that underpin epigenetic inheritance of CpG methylation and histone H3 lysine 9 methylation (H3K9me) in chromatin in fungi and mammals. CpG methylation can be faith...
doi.org
January 7, 2025 at 1:22 AM
Happy New Year, blue-sci-peeps!
My piece in Annual Review of Biophysics on chromatin replication is now available online.
doi.org/10.1146/annu...
If you have paywall issues, try this link:
madhanilab.ucsf.edu/s/annurev-bi...
My piece in Annual Review of Biophysics on chromatin replication is now available online.
doi.org/10.1146/annu...
If you have paywall issues, try this link:
madhanilab.ucsf.edu/s/annurev-bi...
Reposted by Nicholas Gervais
🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab 🎇🎄
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
December 26, 2024 at 3:01 AM
🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab 🎇🎄
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
Reposted by Nicholas Gervais
Can't wait for this new meeting on drug resistance and tolerance across species and diseases. A principle revealed in one system – maybe using different terminology – could be the big new idea when imported to another!
Abstract deadline in January!
s.embl.org/ees25-01 @EMBO/@embl.org
Abstract deadline in January!
s.embl.org/ees25-01 @EMBO/@embl.org
December 20, 2024 at 7:06 PM
Can't wait for this new meeting on drug resistance and tolerance across species and diseases. A principle revealed in one system – maybe using different terminology – could be the big new idea when imported to another!
Abstract deadline in January!
s.embl.org/ees25-01 @EMBO/@embl.org
Abstract deadline in January!
s.embl.org/ees25-01 @EMBO/@embl.org