Nick Sunderland
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nick-sunderland.bsky.social
Nick Sunderland
@nick-sunderland.bsky.social
23 followers 27 following 0 posts
Cardiology Registrar, Bristol Heart Institute
GW4-CAT PhD Fellow, Integrative Epidemiology Unit, Bristol
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Cardiomyopathies, heart failure, genetics, obesity, arrhythmia and devices.
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Reposted by Nick Sunderland
bristolbrc.bsky.social
📢New project on our website!

@nick-sunderland.bsky.social is using #Genetics to explore the link between #Obesity and heart failure.

A GW4-CAT PhD project with @tomrgaunt.bsky.social, @lpaternoster.bsky.social + Tom Lumbers supervising.

More👉 tinyurl.com/mpnywphw
#Cardiology #HealthInnovation
Exploring the link between obesity and heart failure using genetics
Heart failure is a condition that develops when the heart unable to pump blood around the body as well as it should. It is most common in older people…
tinyurl.com
November 25, 2024 at 11:40 AM
Reposted by Nick Sunderland
seanlzheng.bsky.social
🧬 Our dilated #cardiomyopathy GWAS out today!

📍https://www.nature.com/articles/s41588-024-01952-y

All made possible with friends and collaborators from HERMES Consortium @alberthenry.bsky.social @tomlumbers.bsky.social @jamesware.bsky.social @mrc-lms.bsky.social @imperialnhli.bsky.social #BHF

🧵 👇
November 21, 2024 at 1:35 PM
Reposted by Nick Sunderland
cardioobdoc.bsky.social
Natural Language Processing to Adjudicate Heart Failure Hospitalizations in Global Clinical Trials

www.ahajournals.org/doi/10.1161/...
#Circulation #AHA24 #CardioSky #MesSky
@ahajournals.bsky.social @ahascience.bsky.social
November 17, 2024 at 12:55 AM
Reposted by Nick Sunderland
erictopol.bsky.social
Another GLP-1 drug success. Tirzepatide in heart failure with preserved ejection fraction (HFpEF) with longer term follow-up than 2 previous trials with semaglutide
nejm.org/doi/full/10....
in people with BMI >30; no data yet for HFpEF in people without obesity
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM
Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...
nejm.org
November 16, 2024 at 3:12 PM
Reposted by Nick Sunderland
gpollara.bsky.social
More evidence of immune cell (macrophage) -> stromal cell (fibroblast) inflammatory communication to alter organ function (deleteriously, in this case)
#ImmunoSky

www.nature.com/artic...
Targeting immune–fibroblast cell communication in heart failure
Nature - A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling...
www.nature.com
November 15, 2024 at 3:02 PM
Reposted by Nick Sunderland
dkeedy.bsky.social
I'm excited to share our lab's latest @biorxiv-biophys.bsky.social preprint: www.biorxiv.org/content/10.1... This was a really rewarding collaboration between many folks here at the CUNY ASRC and the Farooqi lab at Cambridge, bridging the human genetics of obesity and some cool molecular biophysics!
Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
August 8, 2024 at 1:59 AM
Reposted by Nick Sunderland
medrxivpreprint.bsky.social
Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions. https://www.medrxiv.org/content/10.1101/2024.07.10.24309772v1
Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions. https://www.medrxiv.org/content/10.1101/2024.07.10.24309772v1
Background: Multimorbidity, the co-occurrence of multiple long-term conditions (LTCs), is an increas
www.medrxiv.org
July 11, 2024 at 6:59 AM