Chloe M. Hall
@neuro-chlo.bsky.social
TBI, Alzheimer's Disease, mechanobiology & ephys⚙️🧠 | VC Associate at Empirical Ventures (deep science, UK) | Included VC '24
(she/her)
(she/her)
Reposted by Chloe M. Hall
This new miBrain model from MIT has it all:
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
![Image from the MIT Picower article, "MIT invents human brain model with six major cell types to enable personalized disease research, drug discovery" with the following caption: “Cyan staining shows each of the six major cell types [pericytes, astrocytes, endothelial cells, neurons, oligodendrocytes, and microglia] integrated in a miBrain culture.” The original image appeared in Figure 1 of the PNAS article, “Engineered 3D immuno-glial-neurovascular human miBrain model” (10.1073/pnas.2511596122) by Stanton et al.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:in2pnzujy66a7qnesoxha6ar/bafkreig4udiootxzzdxay4vwclppbwedfythnr36dzzoavgbrzvz2m54va@jpeg)
November 3, 2025 at 7:28 PM
This new miBrain model from MIT has it all:
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
Reposted by Chloe M. Hall
A new #FluorescenceFriday for today! ✨🔬🧠
My 1st time assembling a full #BloodBrainBarrier in a #microfluidic device.
🔴 Claudin 5 (endothelial protein)
🟡 ZO-1 (endothelial protein)
🟢 GFAP (astrocytes)
🔵 DAPI (cell nuclei)
🟣 NG2 (pericytes)
#neuroskyence #neuroscience #bbb #microscopy #confocal
My 1st time assembling a full #BloodBrainBarrier in a #microfluidic device.
🔴 Claudin 5 (endothelial protein)
🟡 ZO-1 (endothelial protein)
🟢 GFAP (astrocytes)
🔵 DAPI (cell nuclei)
🟣 NG2 (pericytes)
#neuroskyence #neuroscience #bbb #microscopy #confocal
March 28, 2025 at 4:01 PM
A new #FluorescenceFriday for today! ✨🔬🧠
My 1st time assembling a full #BloodBrainBarrier in a #microfluidic device.
🔴 Claudin 5 (endothelial protein)
🟡 ZO-1 (endothelial protein)
🟢 GFAP (astrocytes)
🔵 DAPI (cell nuclei)
🟣 NG2 (pericytes)
#neuroskyence #neuroscience #bbb #microscopy #confocal
My 1st time assembling a full #BloodBrainBarrier in a #microfluidic device.
🔴 Claudin 5 (endothelial protein)
🟡 ZO-1 (endothelial protein)
🟢 GFAP (astrocytes)
🔵 DAPI (cell nuclei)
🟣 NG2 (pericytes)
#neuroskyence #neuroscience #bbb #microscopy #confocal
Interesting, initiative for looking at performance of blood tests for Alzheimer’s biomarkers : www.globenewswire.com/news-release...
The Global CEO Initiative on Alzheimer’s Disease Launches Groundbreaking Alzheimer’s Blood Test Performance Database for Clinicians
A First-of-Its-Kind Resource Empowering Clinicians with Clear, Comparative Insights on Alzheimer’s Blood Test Performance...
www.globenewswire.com
March 27, 2025 at 5:34 PM
Interesting, initiative for looking at performance of blood tests for Alzheimer’s biomarkers : www.globenewswire.com/news-release...
Wondering how neuroscience therapies are being developed? And who is funding them? I wrote an article about this: medium.com/included-vc/...
🟦🧠
#neuroskyence
Feel free to reach out to discuss!
🟦🧠
#neuroskyence
Feel free to reach out to discuss!
Sourcing in the sulci of deeptech: neuroscience therapeutics
🚨 I’m a neuroscientist- I could wax lyrical about the details of these diseases for YEARS. In fact, I have. But in order to focus on the…
medium.com
February 27, 2025 at 1:38 PM
Wondering how neuroscience therapies are being developed? And who is funding them? I wrote an article about this: medium.com/included-vc/...
🟦🧠
#neuroskyence
Feel free to reach out to discuss!
🟦🧠
#neuroskyence
Feel free to reach out to discuss!
Reposted by Chloe M. Hall
SCIENTISTS DO NOT COMPLY.
THE GOV DOES NOT CONTROL INDEPENDENT PUBLISHING.
Keep on publishing data!!!! Fight back!!!
THE GOV DOES NOT CONTROL INDEPENDENT PUBLISHING.
Keep on publishing data!!!! Fight back!!!
“The CDC has instructed its scientists to retract or pause the publication of any research manuscript being considered by any medical or scientific journal, not merely its own internal periodicals, Inside Medicine has learned.”
insidemedicine.substack.com/p/breaking-n...
insidemedicine.substack.com/p/breaking-n...
BREAKING NEWS: CDC orders mass retraction and revision of submitted research across all science and medicine journals. Banned terms must be scrubbed.
Any unpublished manuscript mentioning certain topics, including gender and "LGBT," must be pulled or revised.
insidemedicine.substack.com
February 2, 2025 at 6:25 PM
SCIENTISTS DO NOT COMPLY.
THE GOV DOES NOT CONTROL INDEPENDENT PUBLISHING.
Keep on publishing data!!!! Fight back!!!
THE GOV DOES NOT CONTROL INDEPENDENT PUBLISHING.
Keep on publishing data!!!! Fight back!!!
Encoding of recent memories happens in a distinct phase of sleep compared to replay of older ones.
Nitty gritty: disruption of sleep of 1 substate (small-pupil dilation) of NREM sleep (🐭) reduced remembering of recently acquired but not older existing knowledge
www.nature.com/articles/s41...
Nitty gritty: disruption of sleep of 1 substate (small-pupil dilation) of NREM sleep (🐭) reduced remembering of recently acquired but not older existing knowledge
www.nature.com/articles/s41...
Sleep microstructure organizes memory replay - Nature
The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.
www.nature.com
January 21, 2025 at 4:37 PM
Encoding of recent memories happens in a distinct phase of sleep compared to replay of older ones.
Nitty gritty: disruption of sleep of 1 substate (small-pupil dilation) of NREM sleep (🐭) reduced remembering of recently acquired but not older existing knowledge
www.nature.com/articles/s41...
Nitty gritty: disruption of sleep of 1 substate (small-pupil dilation) of NREM sleep (🐭) reduced remembering of recently acquired but not older existing knowledge
www.nature.com/articles/s41...
Reposted by Chloe M. Hall
Why don’t new memories overwrite old ones? It appears that this is because the brain processes new and old memories in separate phases of sleep, which might prevent mixing between the two.
Full details in this nature paper www.nature.com/articles/s41...
🧪
www.nature.com/articles/d41...
Full details in this nature paper www.nature.com/articles/s41...
🧪
www.nature.com/articles/d41...
Why don’t new memories overwrite old ones? Sleep science holds clues
Research in mice points towards a mechanism that avoids ‘catastrophic forgetting’.
www.nature.com
January 7, 2025 at 8:11 AM
Why don’t new memories overwrite old ones? It appears that this is because the brain processes new and old memories in separate phases of sleep, which might prevent mixing between the two.
Full details in this nature paper www.nature.com/articles/s41...
🧪
www.nature.com/articles/d41...
Full details in this nature paper www.nature.com/articles/s41...
🧪
www.nature.com/articles/d41...
Reposted by Chloe M. Hall
Important study result;
Vaccines alone don’t protect you from COVID’s brain damage. They help, but not enough.
Only thing you can do to prevent brain damage completely is avoid infection in the first place.
Mask up in crowded and poorly ventilated spaces. (Yes there is a COVID resurgence)
Vaccines alone don’t protect you from COVID’s brain damage. They help, but not enough.
Only thing you can do to prevent brain damage completely is avoid infection in the first place.
Mask up in crowded and poorly ventilated spaces. (Yes there is a COVID resurgence)
January 5, 2025 at 6:03 AM
Important study result;
Vaccines alone don’t protect you from COVID’s brain damage. They help, but not enough.
Only thing you can do to prevent brain damage completely is avoid infection in the first place.
Mask up in crowded and poorly ventilated spaces. (Yes there is a COVID resurgence)
Vaccines alone don’t protect you from COVID’s brain damage. They help, but not enough.
Only thing you can do to prevent brain damage completely is avoid infection in the first place.
Mask up in crowded and poorly ventilated spaces. (Yes there is a COVID resurgence)
Have you ever heard of DNA for storing data? I wrote my first ever deepdive on it, as part of Included VC: check it out here and let me know what you think!
medium.com/included-vc/...
medium.com/included-vc/...
DNArchives: banking on molecular memory
Taking inspiration from biology to externalise memory.
medium.com
December 30, 2024 at 6:23 PM
Have you ever heard of DNA for storing data? I wrote my first ever deepdive on it, as part of Included VC: check it out here and let me know what you think!
medium.com/included-vc/...
medium.com/included-vc/...
Amazing work from Science Corp: biohybrid implant brain-chip interface- they've grown (🐭) neurons on a microwell which remain viable over weeks, exhibit spontaneous activity and integrate with the mouse brain🤯 🧠🟦
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 28, 2024 at 11:09 PM
Amazing work from Science Corp: biohybrid implant brain-chip interface- they've grown (🐭) neurons on a microwell which remain viable over weeks, exhibit spontaneous activity and integrate with the mouse brain🤯 🧠🟦
www.biorxiv.org/content/10.1...
Reposted by Chloe M. Hall
"Large language models surpass human experts in predicting neuroscience results" w @ken-lxl.bsky.social
and braingpt.org. LLMs integrate a noisy yet interrelated scientific literature to forecast outcomes. nature.com/articles/s41... 1/8
and braingpt.org. LLMs integrate a noisy yet interrelated scientific literature to forecast outcomes. nature.com/articles/s41... 1/8
November 27, 2024 at 2:13 PM
"Large language models surpass human experts in predicting neuroscience results" w @ken-lxl.bsky.social
and braingpt.org. LLMs integrate a noisy yet interrelated scientific literature to forecast outcomes. nature.com/articles/s41... 1/8
and braingpt.org. LLMs integrate a noisy yet interrelated scientific literature to forecast outcomes. nature.com/articles/s41... 1/8
Excited to be presenting my work using the HD-MEA and human cortical organoids Thursday morning, Poster 293 at #FENS2024. Please stop by, especially if you’re interested in ephys in organoids 🧠
June 27, 2024 at 6:46 AM
Excited to be presenting my work using the HD-MEA and human cortical organoids Thursday morning, Poster 293 at #FENS2024. Please stop by, especially if you’re interested in ephys in organoids 🧠
Interesting way to compare differences between studies
onlinelibrary.wiley.com/doi/10.1002/...
#statssky
onlinelibrary.wiley.com/doi/10.1002/...
#statssky
Standardized mean differences in meta‐analysis: A tutorial
This tutorial focuses on standardized mean differences (SMD) as effect measures in meta-analyses. We will explain what they are when they should be used, how to correctly compute and interpret them, ....
onlinelibrary.wiley.com
March 12, 2024 at 12:02 PM
Interesting way to compare differences between studies
onlinelibrary.wiley.com/doi/10.1002/...
#statssky
onlinelibrary.wiley.com/doi/10.1002/...
#statssky
Reposted by Chloe M. Hall
"Large language models surpass human experts in predicting neuroscience results" w @ken-lxl.bsky.social and braingpt.org. LLMs integrate a noisy yet interrelated scientific literature to forecast outcomes. arxiv.org/abs/2403.03230 1/6
Large language models surpass human experts in predicting...
Scientific discoveries often hinge on synthesizing decades of research, a task that potentially outstrips human information processing capacities. Large language models (LLMs) offer a solution....
arxiv.org
March 7, 2024 at 10:48 AM
"Large language models surpass human experts in predicting neuroscience results" w @ken-lxl.bsky.social and braingpt.org. LLMs integrate a noisy yet interrelated scientific literature to forecast outcomes. arxiv.org/abs/2403.03230 1/6
Reposted by Chloe M. Hall
Is backpropagation truly the most efficient way for neural networks to learn? Would more biologically plausible algorithms be more efficient? #AI #ArtificialIntelligence #NeuralNetworks #neuroscience 🧪
February 24, 2024 at 1:26 PM
Is backpropagation truly the most efficient way for neural networks to learn? Would more biologically plausible algorithms be more efficient? #AI #ArtificialIntelligence #NeuralNetworks #neuroscience 🧪
Team #neuroskyence- how many cells can I expect to get per pup in a p1 mouse hippocampus culture? 🧠🧐
February 20, 2024 at 10:49 AM
Team #neuroskyence- how many cells can I expect to get per pup in a p1 mouse hippocampus culture? 🧠🧐
github.com/cxli233/Frie... Such a lovely data vis blog / guide !
GitHub - cxli233/FriendsDontLetFriends at v3
Friends don't let friends make certain types of data visualization - What are they and why are they bad. - GitHub - cxli233/FriendsDontLetFriends at v3
github.com
January 22, 2024 at 11:57 AM
github.com/cxli233/Frie... Such a lovely data vis blog / guide !
It’s beautiful to see how medical students are the same in the UK and Germany… forever complaining about the Krebs cycle 😂
January 19, 2024 at 9:41 AM
It’s beautiful to see how medical students are the same in the UK and Germany… forever complaining about the Krebs cycle 😂
Reposted by Chloe M. Hall
I made a #BioImageAnalysis #GPT 🎉
Compared to #chatGPT it provides more concise hints for processing fluorescence microscopy images using Python libraries my collaborators and yours truly maintain. Thanks to all contributors and as usual: Feedback is 💚ly welcome! 🤗
chat.openai.com/g/g-psAohb1O...
Compared to #chatGPT it provides more concise hints for processing fluorescence microscopy images using Python libraries my collaborators and yours truly maintain. Thanks to all contributors and as usual: Feedback is 💚ly welcome! 🤗
chat.openai.com/g/g-psAohb1O...
January 7, 2024 at 5:26 PM
I made a #BioImageAnalysis #GPT 🎉
Compared to #chatGPT it provides more concise hints for processing fluorescence microscopy images using Python libraries my collaborators and yours truly maintain. Thanks to all contributors and as usual: Feedback is 💚ly welcome! 🤗
chat.openai.com/g/g-psAohb1O...
Compared to #chatGPT it provides more concise hints for processing fluorescence microscopy images using Python libraries my collaborators and yours truly maintain. Thanks to all contributors and as usual: Feedback is 💚ly welcome! 🤗
chat.openai.com/g/g-psAohb1O...
Reposted by Chloe M. Hall
Big 2024 announcement! The “Guide to Effect Sizes and Confidence Intervals” had a pretty substantial update and is slowly becoming the most comprehensive resource on effect sizes and confidence intervals. Here is a thread of some of the new additions 1/5 t.co/ByeSMQNJdp
Guide to Effect Sizes and Confidence Intervals
t.co
January 2, 2024 at 3:09 AM
Big 2024 announcement! The “Guide to Effect Sizes and Confidence Intervals” had a pretty substantial update and is slowly becoming the most comprehensive resource on effect sizes and confidence intervals. Here is a thread of some of the new additions 1/5 t.co/ByeSMQNJdp
Reposted by Chloe M. Hall
Mein Hirn, wenn ich abends im Bett liege und schlafen will.
December 21, 2023 at 11:19 PM
Mein Hirn, wenn ich abends im Bett liege und schlafen will.
Hi neuroscientists- are you able to outperform an LLM? We have 2 versions of a real neuro abstract, and we need you to find the real one for BrainGPT! Should take around 15-20 mins of your time… #Neuroskyence
research.sc/participant/...
research.sc/participant/...
Powered by Gorilla
Make the world a better place by participating in cutting edge behavioural research. Powered by Gorilla
research.sc
December 19, 2023 at 11:55 AM
Hi neuroscientists- are you able to outperform an LLM? We have 2 versions of a real neuro abstract, and we need you to find the real one for BrainGPT! Should take around 15-20 mins of your time… #Neuroskyence
research.sc/participant/...
research.sc/participant/...
Is anyone working on brain organoids? It'd be nice to find a community #Neuroskyence
December 13, 2023 at 4:17 PM
Is anyone working on brain organoids? It'd be nice to find a community #Neuroskyence
Reposted by Chloe M. Hall
There are 11 questions, which should take 15-20 minutes. At the end, you get to see how you did, and will have the option of being publicly acknowledged and entering a raffle for a BrainGPT t-shirt. Be a part of the future of neuroscience and help out! research.sc/participant/... 2/2
December 11, 2023 at 10:50 AM
There are 11 questions, which should take 15-20 minutes. At the end, you get to see how you did, and will have the option of being publicly acknowledged and entering a raffle for a BrainGPT t-shirt. Be a part of the future of neuroscience and help out! research.sc/participant/... 2/2
Reposted by Chloe M. Hall
How predictable is neuroscience? Can LLMs outperform humans? Please participate in the BrainGPT.org survey to help us find out. You choose between two versions of a neuro abstract: the original vs. one with altered results. Which is which? research.sc/participant/... 1/2
Powered by Gorilla
Make the world a better place by participating in cutting edge behavioural research. Powered by Gorilla
research.sc
December 11, 2023 at 10:50 AM
How predictable is neuroscience? Can LLMs outperform humans? Please participate in the BrainGPT.org survey to help us find out. You choose between two versions of a neuro abstract: the original vs. one with altered results. Which is which? research.sc/participant/... 1/2