By now, you've probably heard a lot about the potential changes to NIH funding structures and indirect costs, but what are they?

In this article, Wyss Director of Research Administration Keleigh Quinn shares insights into indirect costs and experiences from her career.

#NIH #ResearchFunding

Join us for a live webinar on Monday, February 24th at 11AM EST to hear Dr. Alican Ozkan from the Wyss Institute share groundbreaking insights into modeling Inflammatory Bowel Disease (IBD) with Organ-on-a-Chip technology. Learn more: emulatebio.com/event/human-...

#ArteryOnAChip

Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)

Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm

#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...

What if your own tumors could be converted to help fight ovarian cancer?

Wyss Institute at Harvard University will help address critical unmet challenges in women’s health for our #SprintForWomensHealth! 👏 arpa-h.gov/engage-and-t...

@harvardchanschool.bsky.social

#Neurovasculature changes from the #arterial to the #venular end. Here I have tried to draw the #cell morphologies realistically. #Endothelialcells go from spindle shaped to rhombic shaped and #muralcells from #smoothmuscle to #pericytes. #Astrocytes same shape. www.sciencedirect.com/science/arti...

Endothelial inflammation in COVID-19

"Disrupted endothelial function underlies the multiorgan complications of COVID-19" with long term effects in #LongCovid @ScienceMagazine

(and yes, endothelial dysfunction in acute and LC was known in 2020-1)

www.science.org/doi/10.1126/...

ieeexplore.ieee.org/document/107...

#SpaceVascularBiology #VascularAging

#VesselOnAChip
#EndothelialCell +PET membrane + #SmoothMuscleCell

#Microgravity (clinostat-simulated)
⬆️ #Senescence EC SMC
rescued by
1️⃣Laminar Shear
2️⃣EC-SMC co-culture
3️⃣ siRNA #Piezo1 in SMCs

Biosens Bioelectron 2024
www.sciencedirect.com/science/arti...

#CerebralCavernousMalformation

Visualizing the Flow architecture & Thrombosis (in peculiarly dilated vessels with sluggish flow) of ear skin lesions of CCM mice
Cdh5-CreERT2::Ccm3f/f

Sox7 as arterial #EndothelialCellMarker

#ATVB 2024 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...