Nature Reviews Gastroenterology & Hepatology, Published online: 17 November 2025; doi:10.1038/s41575-025-01138-9Despite the high incidence and mortality rates of hepatopancreatobiliary cancers in the African continent, epidemiological and clinical data are scarce. This Roadmap article describes the efforts of the Africa HepatoPancreatoBiliary Cancer Consortium to establish cancer registries in the region.

Nature Reviews Gastroenterology & Hepatology, Published online: 17 November 2025; doi:10.1038/s41575-025-01143-yThis Review examines how advances in tumour biology, immunogenomics and graft preservation are redefining surgical management of hepatocellular carcinoma. Malik et al. describe the shift from anatomical to biology-informed paradigms to individualize surgical decision-making.

Nature Reviews Gastroenterology & Hepatology, Published online: 10 November 2025; doi:10.1038/s41575-025-01142-zThe liver is a key metabolic organ that influences metabolic homeostasis by communicating with the central nervous system. This Review discusses the role of gut–liver–brain communication in chronic liver disease, highlighting underlying mechanisms and signalling pathways.

Nature Reviews Gastroenterology & Hepatology, Published online: 10 November 2025; doi:10.1038/s41575-025-01141-0In this Review, the authors discuss the role of the main IL-1 family members in gastrointestinal and liver diseases, focusing on preclinical and clinical research. Opportunities for therapeutic interventions are also outlined.

Nature Reviews Gastroenterology & Hepatology, Published online: 14 November 2025; doi:10.1038/s41575-025-01154-9A new case report of successful treatment of refractory ulcerative colitis with CD19-directed chimeric antigen receptor T cell therapy sheds light on the role of B lineage cells in disease pathogenesis and the possibility of an ‘immune reset’. This approach could reshape therapeutic strategies, although its long-term efficacy, safety and positioning remain open questions.

Nature Reviews Gastroenterology & Hepatology, Published online: 14 November 2025; doi:10.1038/s41575-025-01154-9A new case report of successful treatment of refractory ulcerative colitis with CD19-directed chimeric antigen receptor T cell therapy sheds light on the role of B lineage cells in disease pathogenesis and the possibility of an ‘immune reset’. This approach could reshape therapeutic strategies, although its long-term efficacy, safety and positioning remain open questions.

Nature Reviews Gastroenterology & Hepatology, Published online: 12 November 2025; doi:10.1038/s41575-025-01150-zPatients with pancreatic exocrine insufficiency are treated with pancreatic enzyme replacement therapy. However, there are several challenges facing the future of this treatment, including infectious agents and the presence of microplastics and nanoplastics.

Nature Reviews Gastroenterology & Hepatology - Patients with pancreatic exocrine insufficiency are treated with pancreatic enzyme replacement therapy. However, there are several challenges...

Nature Reviews Gastroenterology & Hepatology, Published online: 12 November 2025; doi:10.1038/s41575-025-01150-zPatients with pancreatic exocrine insufficiency are treated with pancreatic enzyme replacement therapy. However, there are several challenges facing the future of this treatment, including infectious agents and the presence of microplastics and nanoplastics.

Nature Reviews Gastroenterology & Hepatology, Published online: 10 November 2025; doi:10.1038/s41575-025-01142-zThe liver is a key metabolic organ that influences metabolic homeostasis by communicating with the central nervous system. This Review discusses the role of gut–liver–brain communication in chronic liver disease, highlighting underlying mechanisms and signalling pathways.

Nature Reviews Gastroenterology & Hepatology, Published online: 10 November 2025; doi:10.1038/s41575-025-01141-0In this Review, the authors discuss the role of the main IL-1 family members in gastrointestinal and liver diseases, focusing on preclinical and clinical research. Opportunities for therapeutic interventions are also outlined.

Nature Reviews Gastroenterology & Hepatology, Published online: 05 November 2025; doi:10.1038/s41575-025-01151-yPredicting mortality in cirrhosis

Nature Reviews Gastroenterology & Hepatology, Published online: 05 November 2025; doi:10.1038/s41575-025-01134-zThe gut virome is a complex ecosystem and has a critical role in human health. This Review outlines gut virome composition and functional relevance, and its role in human health and disease. Methodological challenges in advancing our knowledge of the gut virome are also discussed.

Nature Reviews Gastroenterology & Hepatology, Published online: 05 November 2025; doi:10.1038/s41575-025-01152-xUEG Week 2025

Nature Reviews Gastroenterology & Hepatology, Published online: 10 November 2025; doi:10.1038/s41575-025-01142-zThe liver is a key metabolic organ that influences metabolic homeostasis by communicating with the central nervous system. This Review discusses the role of gut–liver–brain communication in chronic liver disease, highlighting underlying mechanisms and signalling pathways.

Nature Reviews Gastroenterology & Hepatology, Published online: 10 November 2025; doi:10.1038/s41575-025-01141-0In this Review, the authors discuss the role of the main IL-1 family members in gastrointestinal and liver diseases, focusing on preclinical and clinical research. Opportunities for therapeutic interventions are also outlined.

Nature Reviews Gastroenterology & Hepatology, Published online: 03 November 2025; doi:10.1038/s41575-025-01144-xThe year 2025 has seen substantial advances in the understanding and management of metabolic dysfunction-associated steatotic liver disease, providing new insights into its systemic effects. Emerging evidence in 2025 supports integrated heart–liver co-management, translating the concept into actionable clinical strategies.

Nature Reviews Gastroenterology & Hepatology, Published online: 05 November 2025; doi:10.1038/s41575-025-01151-yPredicting mortality in cirrhosis

Nature Reviews Gastroenterology & Hepatology, Published online: 05 November 2025; doi:10.1038/s41575-025-01134-zThe gut virome is a complex ecosystem and has a critical role in human health. This Review outlines gut virome composition and functional relevance, and its role in human health and disease. Methodological challenges in advancing our knowledge of the gut virome are also discussed.

Nature Reviews Gastroenterology & Hepatology, Published online: 05 November 2025; doi:10.1038/s41575-025-01152-xUEG Week 2025

Nature Reviews Gastroenterology & Hepatology, Published online: 05 November 2025; doi:10.1038/s41575-025-01151-yPredicting mortality in cirrhosis

Nature Reviews Gastroenterology & Hepatology, Published online: 05 November 2025; doi:10.1038/s41575-025-01152-xUEG Week 2025

Nature Reviews Gastroenterology & Hepatology, Published online: 05 November 2025; doi:10.1038/s41575-025-01134-zThe gut virome is a complex ecosystem and has a critical role in human health. This Review outlines gut virome composition and functional relevance, and its role in human health and disease. Methodological challenges in advancing our knowledge of the gut virome are also discussed.

Nature Reviews Gastroenterology & Hepatology, Published online: 03 November 2025; doi:10.1038/s41575-025-01144-xThe year 2025 has seen substantial advances in the understanding and management of metabolic dysfunction-associated steatotic liver disease, providing new insights into its systemic effects. Emerging evidence in 2025 supports integrated heart–liver co-management, translating the concept into actionable clinical strategies.