Narayanan Lab
@narayananlab.bsky.social
Systems neuroscientist & Parkinson's neurologist. We map brain circuits of higher-order thought.
@UIowaNeuro
@IowaNeurology
@UIowaNeuro
@IowaNeurology
Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
With Rachel Cole and Jim Cavanagh
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
With Rachel Cole and Jim Cavanagh
May 21, 2025 at 3:53 PM
Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
With Rachel Cole and Jim Cavanagh
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
With Rachel Cole and Jim Cavanagh
Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
May 21, 2025 at 3:50 PM
Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
Lots more details in the paper. This paper challenged our fundamental view of what we think amphetamine does…
May 14, 2025 at 1:49 AM
Lots more details in the paper. This paper challenged our fundamental view of what we think amphetamine does…
Amphetamine has been thought to reliably affect timing accuracy. We find in a meta-analysis and in our data that it actually more reliably affects precision:
May 14, 2025 at 1:48 AM
Amphetamine has been thought to reliably affect timing accuracy. We find in a meta-analysis and in our data that it actually more reliably affects precision:
Congrats - awesome work - George A would have read this with interest!
April 2, 2025 at 7:16 PM
Congrats - awesome work - George A would have read this with interest!
May I also suggest contacting your disease-specific patient advocacy organization? For instance, I work in Parkinson's disease - and there are several societies with thousands of members here in Iowa. They need to understand the concrete impacts on patients suffering from Parkinson's disease.
February 9, 2025 at 3:07 AM
May I also suggest contacting your disease-specific patient advocacy organization? For instance, I work in Parkinson's disease - and there are several societies with thousands of members here in Iowa. They need to understand the concrete impacts on patients suffering from Parkinson's disease.
How do we explain these results? We collaborated Rodica Curtu in math who implemented classic drift diffusion models. These DDMs suggest that D1 and D2 neurons provide temporal evidence. Disrupting them decreases the accumulation of temporal evidence – and predicts slowed timing.
5/5
5/5
January 16, 2025 at 3:13 PM
How do we explain these results? We collaborated Rodica Curtu in math who implemented classic drift diffusion models. These DDMs suggest that D1 and D2 neurons provide temporal evidence. Disrupting them decreases the accumulation of temporal evidence – and predicts slowed timing.
5/5
5/5
We’ve previously reported that striatal neuron encode time by linear changes over a temporal interval – and we found that these linear changes in the striatum. However – to our complete surprise – D1 and D2 neurons had *opposite patterns* of ramping!
4/5
4/5
January 16, 2025 at 3:12 PM
We’ve previously reported that striatal neuron encode time by linear changes over a temporal interval – and we found that these linear changes in the striatum. However – to our complete surprise – D1 and D2 neurons had *opposite patterns* of ramping!
4/5
4/5
In line with our pharmacology data, we found that optogenetically inactivating either D2 or D1 MSNs slowed temporal control of action:
3/5
3/5
January 16, 2025 at 3:12 PM
In line with our pharmacology data, we found that optogenetically inactivating either D2 or D1 MSNs slowed temporal control of action:
3/5
3/5
This works starts pharmacology showing that dopamine controls the timing of movement. Our work with blocking dopamine receptors systemically – and where they are most abundantly expressed – in the striatum -shows that blocking either D1 or D2 dopamine receptors slows temporal control of action:
January 16, 2025 at 3:11 PM
This works starts pharmacology showing that dopamine controls the timing of movement. Our work with blocking dopamine receptors systemically – and where they are most abundantly expressed – in the striatum -shows that blocking either D1 or D2 dopamine receptors slows temporal control of action: