Narayanan Lab
@narayananlab.bsky.social
Systems neuroscientist & Parkinson's neurologist. We map brain circuits of higher-order thought.
@UIowaNeuro
@IowaNeurology
@UIowaNeuro
@IowaNeurology
Congrats to Alexandra Bova on winning a BBRF Young Investigator Award!
November 10, 2025 at 8:19 PM
Congrats to Alexandra Bova on winning a BBRF Young Investigator Award!
Our issue on Computational Properties of the Prefrontal Cortex is now:
www.jneurosci.org/content/45/3...
These articles capture some of the incandescence of the CPPC conferences...
narayanan.lab.uiowa.edu/home/cppc2024
cppc.web.ox.ac.uk
accl.psy.vanderbilt.edu/blog/2018/10...
www.jneurosci.org/content/45/3...
These articles capture some of the incandescence of the CPPC conferences...
narayanan.lab.uiowa.edu/home/cppc2024
cppc.web.ox.ac.uk
accl.psy.vanderbilt.edu/blog/2018/10...
The Journal of Neuroscience: 45 (37)
www.jneurosci.org
September 10, 2025 at 6:22 PM
Our issue on Computational Properties of the Prefrontal Cortex is now:
www.jneurosci.org/content/45/3...
These articles capture some of the incandescence of the CPPC conferences...
narayanan.lab.uiowa.edu/home/cppc2024
cppc.web.ox.ac.uk
accl.psy.vanderbilt.edu/blog/2018/10...
www.jneurosci.org/content/45/3...
These articles capture some of the incandescence of the CPPC conferences...
narayanan.lab.uiowa.edu/home/cppc2024
cppc.web.ox.ac.uk
accl.psy.vanderbilt.edu/blog/2018/10...
D1FLP mice are now available from JAX!
www.jax.org/strain/039507
Detailed in this paper: pubmed.ncbi.nlm.nih.gov/39701542/
Let us know if they work for you...
www.jax.org/strain/039507
Detailed in this paper: pubmed.ncbi.nlm.nih.gov/39701542/
Let us know if they work for you...
039507 - Drd1-Flpo Strain Details
www.jax.org
August 11, 2025 at 3:43 PM
D1FLP mice are now available from JAX!
www.jax.org/strain/039507
Detailed in this paper: pubmed.ncbi.nlm.nih.gov/39701542/
Let us know if they work for you...
www.jax.org/strain/039507
Detailed in this paper: pubmed.ncbi.nlm.nih.gov/39701542/
Let us know if they work for you...
Our latest paper predicting PD mortality from ~2 minutes of resting-state EEG : www.medrxiv.org/content/10.1...
Linear predictive coding electroencephalography algorithms predict Parkinson's disease mortality using out-of-sample tests
Background: Parkinson's disease (PD) increases mortality is difficult to predict because of its heterogeneity and the availability of very few reliable which prognostic markers. Objectives: We used el...
www.medrxiv.org
July 9, 2025 at 2:28 PM
Our latest paper predicting PD mortality from ~2 minutes of resting-state EEG : www.medrxiv.org/content/10.1...
Our latest work: www.biorxiv.org/content/10.1...
We show that corticostriatal ramping activity can't readily be explained by movements using motion tracking, and that ramping can't readily be explained by reward anticipation in mice performing timing and Pavlovian tasks.
We show that corticostriatal ramping activity can't readily be explained by movements using motion tracking, and that ramping can't readily be explained by reward anticipation in mice performing timing and Pavlovian tasks.
Timing, movement, and reward contributions to prefrontal and striatal ramping activity
Across species, prefrontal and striatal neurons exhibit time-dependent ramping activity, defined as a consistent monotonic change in firing rate across temporal intervals. However, it is unclear if ra...
www.biorxiv.org
July 4, 2025 at 1:50 PM
Our latest work: www.biorxiv.org/content/10.1...
We show that corticostriatal ramping activity can't readily be explained by movements using motion tracking, and that ramping can't readily be explained by reward anticipation in mice performing timing and Pavlovian tasks.
We show that corticostriatal ramping activity can't readily be explained by movements using motion tracking, and that ramping can't readily be explained by reward anticipation in mice performing timing and Pavlovian tasks.
write-up of our amphetamine paper: www.psypost.org/amphetamine-...
Amphetamine scrambles the brain's sense of time by degrading prefrontal neuron coordination
Researchers have found that amphetamine alters how the brain processes time, increasing variability in the activity of neurons that encode temporal information. The study provides insight into how the...
www.psypost.org
May 19, 2025 at 11:22 AM
write-up of our amphetamine paper: www.psypost.org/amphetamine-...
another new preprint from our group on predicting cognitive changes in PD from resting state fMRI: medrxiv.org/content/10.1...
| medRxiv
medRxiv - The Preprint Server for Health Sciences
https://medrxiv.org/content/10.1101/2025.05.13.25327462v1…
May 15, 2025 at 7:30 PM
another new preprint from our group on predicting cognitive changes in PD from resting state fMRI: medrxiv.org/content/10.1...
Our latest preprint on projection-specific tracing of prefrontal activity: www.biorxiv.org/cgi/content/...
Diverse activity in prefrontal projections promotes temporal control of action
Prefrontal neurons can have diverse activity during cognitive functions like working memory, attention, and timing; however, the importance of this heterogeneity is unclear. Our goal was to better und...
www.biorxiv.org
May 14, 2025 at 9:48 PM
Our latest preprint on projection-specific tracing of prefrontal activity: www.biorxiv.org/cgi/content/...
Our work showing that amphetamine affects behavior by degrading prefrontal temporal variability is now out at Neuropharmacology: doi.org/10.1016/j.ne...
Work by Matthew Weber and colleagues:
As always, data and code at: narayanan.lab.uiowa.edu/datasets
Work by Matthew Weber and colleagues:
As always, data and code at: narayanan.lab.uiowa.edu/datasets
May 14, 2025 at 1:48 AM
Our work showing that amphetamine affects behavior by degrading prefrontal temporal variability is now out at Neuropharmacology: doi.org/10.1016/j.ne...
Work by Matthew Weber and colleagues:
As always, data and code at: narayanan.lab.uiowa.edu/datasets
Work by Matthew Weber and colleagues:
As always, data and code at: narayanan.lab.uiowa.edu/datasets
New preprint from our group showing that drugs that enhance glycolysis slow neurodegeneration in Alzheimer's disease - data from yeast to humans:
www.biorxiv.org/content/10.1...
data: bit.ly/GlycolysisANDAD
Data and code : narayanan.lab.uiowa.edu/home/data
www.biorxiv.org/content/10.1...
data: bit.ly/GlycolysisANDAD
Data and code : narayanan.lab.uiowa.edu/home/data
April 3, 2025 at 9:09 PM
New preprint from our group showing that drugs that enhance glycolysis slow neurodegeneration in Alzheimer's disease - data from yeast to humans:
www.biorxiv.org/content/10.1...
data: bit.ly/GlycolysisANDAD
Data and code : narayanan.lab.uiowa.edu/home/data
www.biorxiv.org/content/10.1...
data: bit.ly/GlycolysisANDAD
Data and code : narayanan.lab.uiowa.edu/home/data
What a great looking lab! Best of luck to Mackenzie Rysted at the University of Indiana...
March 12, 2025 at 6:51 PM
What a great looking lab! Best of luck to Mackenzie Rysted at the University of Indiana...
Our latest work is up as a version of record on eLife.
elifesciences.org/articles/96287
This story a long road – but is a major advance on understanding temporal control of action.
As always, data and code are available at narayanan.lab.uiowa.edu/data
1/5
elifesciences.org/articles/96287
This story a long road – but is a major advance on understanding temporal control of action.
As always, data and code are available at narayanan.lab.uiowa.edu/data
1/5
January 16, 2025 at 3:10 PM
Our latest work is up as a version of record on eLife.
elifesciences.org/articles/96287
This story a long road – but is a major advance on understanding temporal control of action.
As always, data and code are available at narayanan.lab.uiowa.edu/data
1/5
elifesciences.org/articles/96287
This story a long road – but is a major advance on understanding temporal control of action.
As always, data and code are available at narayanan.lab.uiowa.edu/data
1/5
Very happy that our paper describing a new D1 FLP mouse is up: pubmed.ncbi.nlm.nih.gov/39701542/
Youngcho Kim's first paper as corresponding author!
Some brief backstory (1/5)
Youngcho Kim's first paper as corresponding author!
Some brief backstory (1/5)
Generation and validation of a D1 dopamine receptor Flpo knock-in mouse - PubMed
We demonstrated brain-wide GFP expression driven by Drd1-Flpo, suggesting that this mouse line may be useful for comprehensive anatomical and functional studies in many brain regions. The Drd1-Flpo mo...
pubmed.ncbi.nlm.nih.gov
December 20, 2024 at 9:59 PM
Very happy that our paper describing a new D1 FLP mouse is up: pubmed.ncbi.nlm.nih.gov/39701542/
Youngcho Kim's first paper as corresponding author!
Some brief backstory (1/5)
Youngcho Kim's first paper as corresponding author!
Some brief backstory (1/5)
Very proud what our nascent Center for Neurodegeneration has done here in Iowa:
December 17, 2024 at 12:17 AM
Very proud what our nascent Center for Neurodegeneration has done here in Iowa:
All this pressure from all these new followers!
Luckily, we have a new preprint:
pubmed.ncbi.nlm.nih.gov/39569181/
Luckily, we have a new preprint:
pubmed.ncbi.nlm.nih.gov/39569181/
Prefrontal projections to the bed nuclei of the stria terminalis modulate the specificity of aversive memories - PubMed
Generalizing aversive memories helps organisms avoid danger, whereas discriminating between dissimilar situations promotes opportunistic behaviors. We identified a novel pathway that controls the cont...
pubmed.ncbi.nlm.nih.gov
November 28, 2024 at 12:10 AM
All this pressure from all these new followers!
Luckily, we have a new preprint:
pubmed.ncbi.nlm.nih.gov/39569181/
Luckily, we have a new preprint:
pubmed.ncbi.nlm.nih.gov/39569181/
Wild - the term 'prefrontal' I think first appeared in 1878 in the journal Brain relating Phineas Gage and other lesions. For the human chauvinists out there - I think the term originates from fish skull anatomy, and in the first description - animal references abound:
November 15, 2024 at 2:15 AM
Wild - the term 'prefrontal' I think first appeared in 1878 in the journal Brain relating Phineas Gage and other lesions. For the human chauvinists out there - I think the term originates from fish skull anatomy, and in the first description - animal references abound:
My re-engagement with BlueSky: Join us at the University of Iowa in the Center for Neurodegeneration:
jobs.uiowa.edu/faculty/view...
medicine.uiowa.edu/neurodegener...
jobs.uiowa.edu/faculty/view...
medicine.uiowa.edu/neurodegener...
Faculty Requisition Details - Jobs@UIOWA: Search and Apply for Jobs at The University of IowaUniversity of IowaUniversity of Iowa
Jobs@UIOWA: The official place to search and apply for jobs at The University of Iowa.
jobs.uiowa.edu
November 11, 2024 at 11:16 PM
My re-engagement with BlueSky: Join us at the University of Iowa in the Center for Neurodegeneration:
jobs.uiowa.edu/faculty/view...
medicine.uiowa.edu/neurodegener...
jobs.uiowa.edu/faculty/view...
medicine.uiowa.edu/neurodegener...
Congrats to our Computational Properties of Prefrontal Cortex 2024 Travel Awardees!
Kenji Lee-BU @kenjilee.bsky.social
Rachel Dick-Univ of Minnesota
Evan Hart-NIDA
Habiba Azab-Baylor
Justin Shin-Brandeis
See you in May 15-17th @ NIH: narayanan.lab.uiowa.edu/cppc2024
Kenji Lee-BU @kenjilee.bsky.social
Rachel Dick-Univ of Minnesota
Evan Hart-NIDA
Habiba Azab-Baylor
Justin Shin-Brandeis
See you in May 15-17th @ NIH: narayanan.lab.uiowa.edu/cppc2024
February 5, 2024 at 5:46 PM
Congrats to our Computational Properties of Prefrontal Cortex 2024 Travel Awardees!
Kenji Lee-BU @kenjilee.bsky.social
Rachel Dick-Univ of Minnesota
Evan Hart-NIDA
Habiba Azab-Baylor
Justin Shin-Brandeis
See you in May 15-17th @ NIH: narayanan.lab.uiowa.edu/cppc2024
Kenji Lee-BU @kenjilee.bsky.social
Rachel Dick-Univ of Minnesota
Evan Hart-NIDA
Habiba Azab-Baylor
Justin Shin-Brandeis
See you in May 15-17th @ NIH: narayanan.lab.uiowa.edu/cppc2024
Out in NPJ Parkinson's disease pubmed.ncbi.nlm.nih.gov/38172519/ engineering.uiowa.edu/news-all/202... Resting-state EEG *strongly* predicts cognition in Parkinson’s disease.
January 24, 2024 at 8:22 PM
Out in NPJ Parkinson's disease pubmed.ncbi.nlm.nih.gov/38172519/ engineering.uiowa.edu/news-all/202... Resting-state EEG *strongly* predicts cognition in Parkinson’s disease.
December 1st is the deadline for trainee awards for CPPC 2024: narayanan.lab.uiowa.edu/cppc2024
Send your CV and poster abstract to james.hyman@unlv.edu
Send your CV and poster abstract to james.hyman@unlv.edu
November 27, 2023 at 3:29 PM
December 1st is the deadline for trainee awards for CPPC 2024: narayanan.lab.uiowa.edu/cppc2024
Send your CV and poster abstract to james.hyman@unlv.edu
Send your CV and poster abstract to james.hyman@unlv.edu
Jacob Simmering's latest preprint that rural ALS is diagnosed differently:
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
October 19, 2023 at 5:26 PM
Jacob Simmering's latest preprint that rural ALS is diagnosed differently:
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Our latest paper is up on medRxiv: www.medrxiv.org/content/10.1...
Congrats to @brookeeyeager.bsky.social for pushing this forward, and to Hunter Twedt on his first paper!
Data and code here: bit.ly/PDCogNetworks or at narayanan.lab.uiowa.edu/article/data...
Congrats to @brookeeyeager.bsky.social for pushing this forward, and to Hunter Twedt on his first paper!
Data and code here: bit.ly/PDCogNetworks or at narayanan.lab.uiowa.edu/article/data...
Salience network and cognitive impairment in Parkinson's disease
medRxiv - The Preprint Server for Health Sciences
www.medrxiv.org
October 16, 2023 at 6:28 PM
Our latest paper is up on medRxiv: www.medrxiv.org/content/10.1...
Congrats to @brookeeyeager.bsky.social for pushing this forward, and to Hunter Twedt on his first paper!
Data and code here: bit.ly/PDCogNetworks or at narayanan.lab.uiowa.edu/article/data...
Congrats to @brookeeyeager.bsky.social for pushing this forward, and to Hunter Twedt on his first paper!
Data and code here: bit.ly/PDCogNetworks or at narayanan.lab.uiowa.edu/article/data...
Congrats to Xin Ding for winning a fellowship from Iowa's graduate college!
October 10, 2023 at 7:12 PM
Congrats to Xin Ding for winning a fellowship from Iowa's graduate college!
Very happy with my word cloud
September 26, 2023 at 1:01 AM
Very happy with my word cloud