Narayanan Lab
@narayananlab.bsky.social
Systems neuroscientist & Parkinson's neurologist. We map brain circuits of higher-order thought.
@UIowaNeuro
@IowaNeurology
@UIowaNeuro
@IowaNeurology
Our lab's posters at SFN:
November 12, 2025 at 9:26 PM
Our lab's posters at SFN:
Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
With Rachel Cole and Jim Cavanagh
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
With Rachel Cole and Jim Cavanagh
May 21, 2025 at 3:53 PM
Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
With Rachel Cole and Jim Cavanagh
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
With Rachel Cole and Jim Cavanagh
Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
May 21, 2025 at 3:50 PM
Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
We find that 4 Hz STN stimulation in *humans* changes decision thresholds:
Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
Lots more details in the paper. This paper challenged our fundamental view of what we think amphetamine does…
May 14, 2025 at 1:49 AM
Lots more details in the paper. This paper challenged our fundamental view of what we think amphetamine does…
Amphetamine has been thought to reliably affect timing accuracy. We find in a meta-analysis and in our data that it actually more reliably affects precision:
May 14, 2025 at 1:48 AM
Amphetamine has been thought to reliably affect timing accuracy. We find in a meta-analysis and in our data that it actually more reliably affects precision:
Our work showing that amphetamine affects behavior by degrading prefrontal temporal variability is now out at Neuropharmacology: doi.org/10.1016/j.ne...
Work by Matthew Weber and colleagues:
As always, data and code at: narayanan.lab.uiowa.edu/datasets
Work by Matthew Weber and colleagues:
As always, data and code at: narayanan.lab.uiowa.edu/datasets
May 14, 2025 at 1:48 AM
Our work showing that amphetamine affects behavior by degrading prefrontal temporal variability is now out at Neuropharmacology: doi.org/10.1016/j.ne...
Work by Matthew Weber and colleagues:
As always, data and code at: narayanan.lab.uiowa.edu/datasets
Work by Matthew Weber and colleagues:
As always, data and code at: narayanan.lab.uiowa.edu/datasets
New preprint from our group showing that drugs that enhance glycolysis slow neurodegeneration in Alzheimer's disease - data from yeast to humans:
www.biorxiv.org/content/10.1...
data: bit.ly/GlycolysisANDAD
Data and code : narayanan.lab.uiowa.edu/home/data
www.biorxiv.org/content/10.1...
data: bit.ly/GlycolysisANDAD
Data and code : narayanan.lab.uiowa.edu/home/data
April 3, 2025 at 9:09 PM
New preprint from our group showing that drugs that enhance glycolysis slow neurodegeneration in Alzheimer's disease - data from yeast to humans:
www.biorxiv.org/content/10.1...
data: bit.ly/GlycolysisANDAD
Data and code : narayanan.lab.uiowa.edu/home/data
www.biorxiv.org/content/10.1...
data: bit.ly/GlycolysisANDAD
Data and code : narayanan.lab.uiowa.edu/home/data
What a great looking lab! Best of luck to Mackenzie Rysted at the University of Indiana...
March 12, 2025 at 6:51 PM
What a great looking lab! Best of luck to Mackenzie Rysted at the University of Indiana...
How do we explain these results? We collaborated Rodica Curtu in math who implemented classic drift diffusion models. These DDMs suggest that D1 and D2 neurons provide temporal evidence. Disrupting them decreases the accumulation of temporal evidence – and predicts slowed timing.
5/5
5/5
January 16, 2025 at 3:13 PM
How do we explain these results? We collaborated Rodica Curtu in math who implemented classic drift diffusion models. These DDMs suggest that D1 and D2 neurons provide temporal evidence. Disrupting them decreases the accumulation of temporal evidence – and predicts slowed timing.
5/5
5/5
We’ve previously reported that striatal neuron encode time by linear changes over a temporal interval – and we found that these linear changes in the striatum. However – to our complete surprise – D1 and D2 neurons had *opposite patterns* of ramping!
4/5
4/5
January 16, 2025 at 3:12 PM
We’ve previously reported that striatal neuron encode time by linear changes over a temporal interval – and we found that these linear changes in the striatum. However – to our complete surprise – D1 and D2 neurons had *opposite patterns* of ramping!
4/5
4/5
In line with our pharmacology data, we found that optogenetically inactivating either D2 or D1 MSNs slowed temporal control of action:
3/5
3/5
January 16, 2025 at 3:12 PM
In line with our pharmacology data, we found that optogenetically inactivating either D2 or D1 MSNs slowed temporal control of action:
3/5
3/5
This works starts pharmacology showing that dopamine controls the timing of movement. Our work with blocking dopamine receptors systemically – and where they are most abundantly expressed – in the striatum -shows that blocking either D1 or D2 dopamine receptors slows temporal control of action:
January 16, 2025 at 3:11 PM
This works starts pharmacology showing that dopamine controls the timing of movement. Our work with blocking dopamine receptors systemically – and where they are most abundantly expressed – in the striatum -shows that blocking either D1 or D2 dopamine receptors slows temporal control of action:
Our latest work is up as a version of record on eLife.
elifesciences.org/articles/96287
This story a long road – but is a major advance on understanding temporal control of action.
As always, data and code are available at narayanan.lab.uiowa.edu/data
1/5
elifesciences.org/articles/96287
This story a long road – but is a major advance on understanding temporal control of action.
As always, data and code are available at narayanan.lab.uiowa.edu/data
1/5
January 16, 2025 at 3:10 PM
Our latest work is up as a version of record on eLife.
elifesciences.org/articles/96287
This story a long road – but is a major advance on understanding temporal control of action.
As always, data and code are available at narayanan.lab.uiowa.edu/data
1/5
elifesciences.org/articles/96287
This story a long road – but is a major advance on understanding temporal control of action.
As always, data and code are available at narayanan.lab.uiowa.edu/data
1/5
Long story short - we get great expression, and about what we might get from Cre mice. This will be a powerful tool for studying these circuits.
They will be up at Jackson (039507) soon.
They will be up at Jackson (039507) soon.
December 20, 2024 at 10:20 PM
Long story short - we get great expression, and about what we might get from Cre mice. This will be a powerful tool for studying these circuits.
They will be up at Jackson (039507) soon.
They will be up at Jackson (039507) soon.
Youngcho integrated FlpO - another conditional expression construct - into the D1 gene. This is distinct from the D1 Cre mice, which uses BAC transgenics:
December 20, 2024 at 10:14 PM
Youngcho integrated FlpO - another conditional expression construct - into the D1 gene. This is distinct from the D1 Cre mice, which uses BAC transgenics:
Very proud what our nascent Center for Neurodegeneration has done here in Iowa:
December 17, 2024 at 12:17 AM
Very proud what our nascent Center for Neurodegeneration has done here in Iowa:
Wild - the term 'prefrontal' I think first appeared in 1878 in the journal Brain relating Phineas Gage and other lesions. For the human chauvinists out there - I think the term originates from fish skull anatomy, and in the first description - animal references abound:
November 15, 2024 at 2:15 AM
Wild - the term 'prefrontal' I think first appeared in 1878 in the journal Brain relating Phineas Gage and other lesions. For the human chauvinists out there - I think the term originates from fish skull anatomy, and in the first description - animal references abound:
February 5, 2024 at 5:48 PM
Congrats to our Computational Properties of Prefrontal Cortex 2024 Travel Awardees!
Kenji Lee-BU @kenjilee.bsky.social
Rachel Dick-Univ of Minnesota
Evan Hart-NIDA
Habiba Azab-Baylor
Justin Shin-Brandeis
See you in May 15-17th @ NIH: narayanan.lab.uiowa.edu/cppc2024
Kenji Lee-BU @kenjilee.bsky.social
Rachel Dick-Univ of Minnesota
Evan Hart-NIDA
Habiba Azab-Baylor
Justin Shin-Brandeis
See you in May 15-17th @ NIH: narayanan.lab.uiowa.edu/cppc2024
February 5, 2024 at 5:46 PM
Congrats to our Computational Properties of Prefrontal Cortex 2024 Travel Awardees!
Kenji Lee-BU @kenjilee.bsky.social
Rachel Dick-Univ of Minnesota
Evan Hart-NIDA
Habiba Azab-Baylor
Justin Shin-Brandeis
See you in May 15-17th @ NIH: narayanan.lab.uiowa.edu/cppc2024
Kenji Lee-BU @kenjilee.bsky.social
Rachel Dick-Univ of Minnesota
Evan Hart-NIDA
Habiba Azab-Baylor
Justin Shin-Brandeis
See you in May 15-17th @ NIH: narayanan.lab.uiowa.edu/cppc2024
Out in NPJ Parkinson's disease pubmed.ncbi.nlm.nih.gov/38172519/ engineering.uiowa.edu/news-all/202... Resting-state EEG *strongly* predicts cognition in Parkinson’s disease.
January 24, 2024 at 8:22 PM
Out in NPJ Parkinson's disease pubmed.ncbi.nlm.nih.gov/38172519/ engineering.uiowa.edu/news-all/202... Resting-state EEG *strongly* predicts cognition in Parkinson’s disease.
And here is an awesome graphic made by: @brookeeyeager.bsky.social
November 9, 2023 at 7:29 PM
And here is an awesome graphic made by: @brookeeyeager.bsky.social
Congrats to Xin Ding for winning a fellowship from Iowa's graduate college!
October 10, 2023 at 7:12 PM
Congrats to Xin Ding for winning a fellowship from Iowa's graduate college!
Very happy with my word cloud
September 26, 2023 at 1:01 AM
Very happy with my word cloud
September 25, 2023 at 12:19 PM