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@myosinactncrazy.bsky.social
930 followers 80 following 290 posts
#1 molecular motor,
cytoskeletal motors, cytoskeletal filaments, filament dynamics, cell migration, mechanobiology, morphogenesis
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www.biorxiv.org/content/10.1...
Form and function of actin impacts actin health and aging.
The actin cytoskeleton is a fundamental and highly conserved structure that functions in diverse cellular processes, yet its direct contribution to organismal aging remains unclear. Here, we systemati...
www.biorxiv.org
November 23, 2025 at 3:28 PM
interesting work revealing differences between evolutionary distant actins!

"..... ADP-actin filaments depolymerize faster and are mechanically more flexible in Saccharomyces cerevisiae compared to Schizosaccharomyces pombe. "

www.biorxiv.org/content/10.1...
Rapid aging and disassembly of actin filaments from two evolutionary distant yeasts
Actin is an essential cytoskeletal protein that is extremely well conserved across the tree of life. Similarities and differences in the way actin from different species self-assembles into filaments ...
www.biorxiv.org
November 22, 2025 at 1:31 PM
www.biorxiv.org/content/10.1...
Enhanced Processivity and Collective Force Production of Kinesin-1 at Low Radial Forces
Kinesin-1 is a robust motor that carries intracellular cargos towards the plus ends of microtubules. However, optical trapping studies reported that kinesin-1 is a slippery motor that quickly detaches...
www.biorxiv.org
November 22, 2025 at 1:25 PM
Reposted
ryotaiino.bsky.social
Active fluctuations of cytoplasmic actomyosin networks facilitate dynein-driven transport: iScience www.cell.com/iscience/ful...
Active fluctuations of cytoplasmic actomyosin networks facilitate dynein-driven transport
Inside cells, molecular motors transport cargo through a highly crowded cytoplasmic environment. While such an environment is assumed to hinder transport, its precise effect remains unclear. Here, we ...
www.cell.com
November 22, 2025 at 1:39 AM
www.pnas.org/doi/10.1073/...
ATP-dependent actin barbed-end fluctuations at steady state | PNAS
Actin networks in cells are dynamic and constantly turning over as actin subunits exchange between monomer and polymer pools. Understanding these d...
www.pnas.org
November 21, 2025 at 12:12 PM
elifesciences.org/reviewed-pre...
Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch
elifesciences.org
November 21, 2025 at 3:16 AM
Filament transport supports contractile steady states of actin
networks.

www.biorxiv.org/content/10.1...
www.biorxiv.org
November 21, 2025 at 1:22 AM
rupress.org/jcb/article/...
Inwardly rectifying potassium channels promote directional sensing during neutrophil chemotaxis | Journal of Cell Biology | Rockefeller University Press
Wang et al. demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during n
rupress.org
November 20, 2025 at 12:41 PM
Reposted
chembiobryan.bsky.social
Check out our newest work! This is a story on how to get selectivity in binders - both isoform and site selectivity. Read the paper or enjoy this brief Skytorial of what we did!

www.biorxiv.org/content/10.1...

1/n
PANCS-spec-Binders: A system for rapidly discovering isoform- or epitope-specific binders
Proteins that bind to a target protein of interest, termed "binders," are essential components of biological research reagents and therapeutics. Target proteins present multiple binding surfaces with ...
www.biorxiv.org
November 19, 2025 at 6:10 PM
Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis

rupress.org/jcb/article-...
Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis
Joly and Pintard uncover how the enzyme Katanin avoids wasting energy during microtubule remodeling. Their findings reveal how Katanin couples activation t
rupress.org
November 20, 2025 at 4:57 AM
awesome postdoc opportunity alert!
guijacquemet.bsky.social Guillaume Jacquemet @guijacquemet.bsky.social · Jul 1
- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
guijacquemet.bsky.social Guillaume Jacquemet @guijacquemet.bsky.social · Jun 23
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
November 19, 2025 at 5:06 AM
www.biorxiv.org/content/10.1...
Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end
Vimentin intermediate filaments play essential roles in maintaining cell integrity and regulating numerous cellular functions. In particular, vimentin cooperates with the actin cytoskeleton in key cel...
www.biorxiv.org
November 18, 2025 at 12:15 PM
Reposted
sarahmoeba.bsky.social
Our work on Naegleria Myosin 2 is out!

Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.

Read more: www.cell.com/current-biol...
Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage
Myosin 2-dependent actin contractility—the force that powers cell division and migration in animals, fungi, and other Amorphea—had been previously unknown outside this single eukaryotic group. Guest e...
www.cell.com
November 17, 2025 at 5:19 PM
Reposted
christoseland.bsky.social
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...

We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
November 14, 2025 at 9:33 AM
Class-I myosin responds to change in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells

www.biorxiv.org/content/10.1...
www.biorxiv.org
November 13, 2025 at 1:02 PM
Myosin-19 and Miro Regulate Mitochondria–Endoplasmic Reticulum Contacts and Mitochondria Inner Membrane Architecture

www.mdpi.com/2073-4409/14...
www.mdpi.com
November 13, 2025 at 12:22 PM
elifesciences.org/articles/895...
Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in mouse pancreatic β cells
Sub-membrane microtubule array, known to prevent excessive glucose-stimulated insulin secretion, depends on kinesin-1 KIF5B, which moves microtubules to both generate and remodel this array, potential...
elifesciences.org
November 12, 2025 at 1:13 PM
journals.asm.org/doi/10.1128/...
Phospho-activated non-muscle myosin IIA heavy chain supports different mechanisms of virus uptake | Journal of Virology
Viral infections represent a major threat to global public health and pose a huge social and economic cost; thus, a better understanding of how cell-intrinsic factors modulate the outcome of infection...
journals.asm.org
November 11, 2025 at 7:41 PM
www.biorxiv.org/content/10.1...
Optical tweezers combined with FRET tension sensor reveal force-dependent vinculin dynamics
Methods to visualize and quantify the molecular responses of cells to local forces exerted at adhesions are crucial to elucidate how physical forces control cellular behavior. Of the many proteins inv...
www.biorxiv.org
November 11, 2025 at 12:16 PM
www.biorxiv.org/content/10.1...
Plasmodium falciparum Myosin F with a Rab-like tail domain localises to perinuclear membranes and associates with trafficking proteins
Members of the myosin superfamily are found in all eukaryotes, including Plasmodium falciparum, the parasite that causes malaria. Plasmodium falciparum expresses six myosins, but apart from PfMyoA, th...
www.biorxiv.org
November 11, 2025 at 12:14 PM
www.cell.com/cell-reports...
The kinesin Kip2 promotes microtubule growth using a bipartite polymerase module to deliver tubulin to microtubule plus ends
Microtubules act as highways in cells, with kinesins transporting cargo and maintaining their length for cell survival. Nadalis et al. show that the yeast kinesin Kip2 promotes microtubule growth by d...
www.cell.com
November 11, 2025 at 12:03 PM
Reposted
athertonlabkcl.bsky.social
Post-doc position alert!

We will use #cryo-EM to decipher how a set of actin-binding proteins organises the #cytoskeleton, including during #cancer and #viral pathogenic processes.

#KCL has access to;
Krios + K3
cryoARM200 + K3
FIB-SEM
Cryo-CLEM

www.timeshighereducation.com/unijobs/list...
November 7, 2025 at 5:31 PM
www.biorxiv.org/content/10.1...
Non-uniform filament turnover and mechanically-driven contractility and bundle formation in disordered actomyosin networks
Bundles of actin filaments with similar positions and orientations commonly occur in cytoskeletal networks. We use mathematical modelling and simulation to investigate how filament turnover and mechan...
www.biorxiv.org
November 8, 2025 at 1:18 PM
www.biorxiv.org/content/10.1...
An actomyosin-mediated mechanical mechanism for brain neural tube elevation
Embryos fold their tissues into increasingly complicated shapes during development. Cells produce and coordinate the forces needed to fold tissues through networks of F-actin and Myosin II (actomyosin...
www.biorxiv.org
November 8, 2025 at 1:17 PM
www.cell.com/cell-reports...
The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility
Zhao et al. identify the molecular machinery for lipid droplet motility, consisting of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor Ldo16. They uncover a molecular l...
www.cell.com
November 8, 2025 at 1:15 PM