Mario van der Stelt
@mvdstelt.bsky.social
Professor of Molecular Physiology at Leiden University.
Chemical Neurobiology & Medicinal Chemistry. Wildlife photography
Chemical Neurobiology & Medicinal Chemistry. Wildlife photography
Reposted by Mario van der Stelt
It also highlights work by the group of @mvdstelt.bsky.social of the @led3hub.bsky.social on profiling the targets of BIA 10-2474 (www.science.org/doi/10.1126/...) as well as the work that @mads-chem.bsky.social performed in Ben Cravatt's lab on JAK1 inhibitors (www.nature.com/articles/s41...) (4/5)
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
A drug that was unexpectedly neurotoxic in a clinical trial has off-target activities in chemical proteomic assays.
www.science.org
July 2, 2025 at 8:36 AM
It also highlights work by the group of @mvdstelt.bsky.social of the @led3hub.bsky.social on profiling the targets of BIA 10-2474 (www.science.org/doi/10.1126/...) as well as the work that @mads-chem.bsky.social performed in Ben Cravatt's lab on JAK1 inhibitors (www.nature.com/articles/s41...) (4/5)
Congratulations and a big thank you to @verenas.bsky.social and the labs of Istvan Katona, Yulong Li, Nephi Stella, and Laura Heitman, Coen van Hasselt at @led3hub.bsky.social and @unileiden.bsky.social for a fantastic collaboration. 4/4
February 21, 2025 at 2:34 PM
Congratulations and a big thank you to @verenas.bsky.social and the labs of Istvan Katona, Yulong Li, Nephi Stella, and Laura Heitman, Coen van Hasselt at @led3hub.bsky.social and @unileiden.bsky.social for a fantastic collaboration. 4/4
Mathematical modelling provided a comprehensive understanding of endocannabinoid signaling. The model addresses key questions in the field and suggests that microvesicles carrying signaling lipids in their membrane regulate neuronal functions in parallel to synaptic vesicles. n/3
February 21, 2025 at 2:34 PM
Mathematical modelling provided a comprehensive understanding of endocannabinoid signaling. The model addresses key questions in the field and suggests that microvesicles carrying signaling lipids in their membrane regulate neuronal functions in parallel to synaptic vesicles. n/3
Our findings led us to propose an “on demand release” model, where microvesicle formation governs endocannabinoid release. This model reconciliates three previously proposed hypotheses for endocannabinoid trafficking. n/2
February 21, 2025 at 2:34 PM
Our findings led us to propose an “on demand release” model, where microvesicle formation governs endocannabinoid release. This model reconciliates three previously proposed hypotheses for endocannabinoid trafficking. n/2