Mario van der Stelt
@mvdstelt.bsky.social
Professor of Molecular Physiology at Leiden University.
Chemical Neurobiology & Medicinal Chemistry. Wildlife photography
Chemical Neurobiology & Medicinal Chemistry. Wildlife photography
Heading home after a fantastic cannabinoid GRC meeting organised by @drjkhokhar.bsky.social and Cecilia Hillard. Hope to see you all in Dijon ICRS-meeting June 28th -July 2nd, 2026 @icrsonbluesky.bsky.social
August 22, 2025 at 6:37 PM
Heading home after a fantastic cannabinoid GRC meeting organised by @drjkhokhar.bsky.social and Cecilia Hillard. Hope to see you all in Dijon ICRS-meeting June 28th -July 2nd, 2026 @icrsonbluesky.bsky.social
Reposted by Mario van der Stelt
It also highlights work by the group of @mvdstelt.bsky.social of the @led3hub.bsky.social on profiling the targets of BIA 10-2474 (www.science.org/doi/10.1126/...) as well as the work that @mads-chem.bsky.social performed in Ben Cravatt's lab on JAK1 inhibitors (www.nature.com/articles/s41...) (4/5)
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
A drug that was unexpectedly neurotoxic in a clinical trial has off-target activities in chemical proteomic assays.
www.science.org
July 2, 2025 at 8:36 AM
It also highlights work by the group of @mvdstelt.bsky.social of the @led3hub.bsky.social on profiling the targets of BIA 10-2474 (www.science.org/doi/10.1126/...) as well as the work that @mads-chem.bsky.social performed in Ben Cravatt's lab on JAK1 inhibitors (www.nature.com/articles/s41...) (4/5)
Reposted by Mario van der Stelt
A new exciting article in @natbiotech.nature.com highlights the power of chemical proteomics to find druggable pockets on difficult high-value targets. Great insights into applications in covalent and non-covalent drug discovery including clinical development. (1/5) www.nature.com/articles/s41...
Probing the proteome - Nature Biotechnology
Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets?
www.nature.com
July 2, 2025 at 8:36 AM
A new exciting article in @natbiotech.nature.com highlights the power of chemical proteomics to find druggable pockets on difficult high-value targets. Great insights into applications in covalent and non-covalent drug discovery including clinical development. (1/5) www.nature.com/articles/s41...
Reposted by Mario van der Stelt
A great talk by Joel Rüegger of the group of @mvdstelt.bsky.social at #FocusOnCovalentDrugs. He talked about his amazing work in the @led3hub.bsky.social on the CellEKT platform for profiling target engagement of kinase inhibitors in living cells. (1/5) www.mcponline.org/article/S153...
April 10, 2025 at 7:53 AM
A great talk by Joel Rüegger of the group of @mvdstelt.bsky.social at #FocusOnCovalentDrugs. He talked about his amazing work in the @led3hub.bsky.social on the CellEKT platform for profiling target engagement of kinase inhibitors in living cells. (1/5) www.mcponline.org/article/S153...
Reposted by Mario van der Stelt
Lipidation of proteins has diverse essential roles in biology.
In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5)
#chemsky #ChemBio
In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5)
#chemsky #ChemBio
March 25, 2025 at 11:58 AM
Lipidation of proteins has diverse essential roles in biology.
In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5)
#chemsky #ChemBio
In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5)
#chemsky #ChemBio
Reposted by Mario van der Stelt
Another “Continuing Crisis” post, this one covering some larger principles and explaining why I’m doing these in general:
The Continuing Crisis, Part VII: An Overview
www.science.org
March 5, 2025 at 6:08 PM
Another “Continuing Crisis” post, this one covering some larger principles and explaining why I’m doing these in general:
Happy to announce on my first bsky post that today our manuscript “The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles” has been published in its final form in PNAS n/1
www.pnas.org
February 21, 2025 at 2:34 PM
Happy to announce on my first bsky post that today our manuscript “The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles” has been published in its final form in PNAS n/1