Ashutosh Kumar
@mudgal17.bsky.social
PhD student at UniFr Switzerland | Phase separation | Computational Bio-physics/chemistry
Reposted by Ashutosh Kumar
Altogether, we think that the mechanism of membrane fusion described in the context of NPC assembly here is different from what known for other fusion machineries (e.g. SNAREs, dynamin-like GTPases,…). More details in the manuscript—let us know your thoughts! (13/13)
July 23, 2025 at 11:55 AM
Altogether, we think that the mechanism of membrane fusion described in the context of NPC assembly here is different from what known for other fusion machineries (e.g. SNAREs, dynamin-like GTPases,…). More details in the manuscript—let us know your thoughts! (13/13)
Reposted by Ashutosh Kumar
When observed closely, lipid mixing looks like classic hemifusion-like intermediates with exposed lipid-tails (but stabilized within protein rings here). (10/13)
July 23, 2025 at 11:51 AM
When observed closely, lipid mixing looks like classic hemifusion-like intermediates with exposed lipid-tails (but stabilized within protein rings here). (10/13)
Reposted by Ashutosh Kumar
While, in a nice collaboration with the Carvalho lab and @joanavferreira.bsky.social, PhD student Yara Ahmed used MD simulations to characterize the binding mechanism of the Dysferlin domain of Pex30 to phosphatidic acid. Anyone interested in a novel PA-sensor? (2/2)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Pex30-dependent membrane contacts sites maintain ER lipid homeostasis
In eukaryotic cells, communication between organelles and the coordination of their activities depend on membrane contact sites (MCS). How MCS are regulated under the dynamic cellular environment rema...
www.biorxiv.org
March 19, 2025 at 3:34 PM
While, in a nice collaboration with the Carvalho lab and @joanavferreira.bsky.social, PhD student Yara Ahmed used MD simulations to characterize the binding mechanism of the Dysferlin domain of Pex30 to phosphatidic acid. Anyone interested in a novel PA-sensor? (2/2)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Would like to be added here✋. Thanks :)
November 22, 2024 at 10:36 AM
Would like to be added here✋. Thanks :)