Marco Sciacovelli
@msciacovellilab.bsky.social
Tenure Track Fellow (Group Leader) at @livuni-ismib.bsky.social, University of Liverpool.
Studying cancer metabolism, mitochondria, metabolite signalling. Views are my own.
Studying cancer metabolism, mitochondria, metabolite signalling. Views are my own.
Reposted by Marco Sciacovelli
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!
!
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
www.sciencedirect.com
October 28, 2025 at 4:25 PM
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!
!
very nice review about how metabolic changes in the tumour microenvironment affect macrophage function: www.sciencedirect.com/science/arti...
Metabolites in the extracellular tumor microenvironment and the shaping of macrophage function
It has been a century since it was discovered that cancer cells have a distorted metabolism compared to healthy cells and tissues. It is now universal…
www.sciencedirect.com
October 22, 2025 at 1:00 PM
very nice review about how metabolic changes in the tumour microenvironment affect macrophage function: www.sciencedirect.com/science/arti...
Reposted by Marco Sciacovelli
nteresting paper showing how HDAC6 interacts and regulates fumarate hydratase (FH) affecting mitochondrial structure www.nature.com/articles/s41...
Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure - Nature Communications
Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy...
www.nature.com
September 2, 2025 at 12:33 PM
nteresting paper showing how HDAC6 interacts and regulates fumarate hydratase (FH) affecting mitochondrial structure www.nature.com/articles/s41...
Reposted by Marco Sciacovelli
Succinate preserves CD8+ T cell fitness to augment antitumor immunity: Immunity www.cell.com/immunity/ful...
Succinate preserves CD8+ T cell fitness to augment antitumor immunity
How various tumoral metabolites impact antitumor T cell immunity is an area of active
research. Ma et al. demonstrate that succinate enhances mitochondrial fitness and
induces epigenetic reprogramming...
www.cell.com
August 15, 2025 at 8:59 AM
Succinate preserves CD8+ T cell fitness to augment antitumor immunity: Immunity www.cell.com/immunity/ful...
Reposted by Marco Sciacovelli
Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...
Silencing mitochondrial gene expression in living cells
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central mechanis...
www.science.org
July 31, 2025 at 6:14 PM
Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...
Reposted by Marco Sciacovelli
Good Sunday all! A great selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you! Loads of cool science!! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"You are the sky. Everything else—it’s just the weather."
Pema Chödrön
"You are the sky. Everything else—it’s just the weather."
Pema Chödrön
a young boy is writing on a piece of paper with the words so many papers written on it
ALT: a young boy is writing on a piece of paper with the words so many papers written on it
media.tenor.com
July 20, 2025 at 4:52 AM
Good Sunday all! A great selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you! Loads of cool science!! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"You are the sky. Everything else—it’s just the weather."
Pema Chödrön
"You are the sky. Everything else—it’s just the weather."
Pema Chödrön
Reposted by Marco Sciacovelli
Good morning all! There are some wonderful papers in #cancermetabolism and #mitochondrialbiology in this curated issue! Don't miss it, find it here: biomed.news/bims-camemi/... @biomednews.bsky.social
#keepreading
"When you argue with reality, you lose, but only 100% of the time." -Byron Katie
#keepreading
"When you argue with reality, you lose, but only 100% of the time." -Byron Katie
a cartoon of a woman reading a book next to a cat and a cup
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media.tenor.com
July 6, 2025 at 5:15 AM
Good morning all! There are some wonderful papers in #cancermetabolism and #mitochondrialbiology in this curated issue! Don't miss it, find it here: biomed.news/bims-camemi/... @biomednews.bsky.social
#keepreading
"When you argue with reality, you lose, but only 100% of the time." -Byron Katie
#keepreading
"When you argue with reality, you lose, but only 100% of the time." -Byron Katie
Reposted by Marco Sciacovelli
Good Sunday, all! There are huge discoveries in this curated summary of papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"The quieter you become, the more you can hear."-Ram Dass
"The quieter you become, the more you can hear."-Ram Dass
two young men are reading a book together in a room
ALT: two young men are reading a book together in a room
media.tenor.com
June 29, 2025 at 5:13 AM
Good Sunday, all! There are huge discoveries in this curated summary of papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"The quieter you become, the more you can hear."-Ram Dass
"The quieter you become, the more you can hear."-Ram Dass
Reposted by Marco Sciacovelli
This week you can join our seminar online @livuni-ismib.bsky.social please check emails for Zoom link Friday
20th June 2025, 11am – 12pm.
Guest Speaker – Max Mazzone
Title – “Harnessing tumor metabolism to overcome immunosuppression”
Host – @mcschmid.bsky.social
Location – Zoom
20th June 2025, 11am – 12pm.
Guest Speaker – Max Mazzone
Title – “Harnessing tumor metabolism to overcome immunosuppression”
Host – @mcschmid.bsky.social
Location – Zoom
June 18, 2025 at 7:27 PM
This week you can join our seminar online @livuni-ismib.bsky.social please check emails for Zoom link Friday
20th June 2025, 11am – 12pm.
Guest Speaker – Max Mazzone
Title – “Harnessing tumor metabolism to overcome immunosuppression”
Host – @mcschmid.bsky.social
Location – Zoom
20th June 2025, 11am – 12pm.
Guest Speaker – Max Mazzone
Title – “Harnessing tumor metabolism to overcome immunosuppression”
Host – @mcschmid.bsky.social
Location – Zoom
Reposted by Marco Sciacovelli
Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming: Cell Metabolism www.cell.com/cell-metabol...
Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming
Zhao et al. uncovered a nuclear-restricted acetyl-CoA regulatory mechanism where nucleus-localized
pyruvate dehydrogenase complex (nPDC) is constitutively bound and repressed by nuclear
protein ELMSAN...
www.cell.com
June 12, 2025 at 2:59 PM
Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming: Cell Metabolism www.cell.com/cell-metabol...
Reposted by Marco Sciacovelli
Good morning, all. Science keeps making excellent progress. Check the curated summary of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
The boundary to what we can accept is the boundary to our freedom.
Tara Brach
The boundary to what we can accept is the boundary to our freedom.
Tara Brach
a penguin is reading a newspaper while another penguin looks on
ALT: a penguin is reading a newspaper while another penguin looks on
media.tenor.com
June 15, 2025 at 6:30 AM
Good morning, all. Science keeps making excellent progress. Check the curated summary of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
The boundary to what we can accept is the boundary to our freedom.
Tara Brach
The boundary to what we can accept is the boundary to our freedom.
Tara Brach
Reposted by Marco Sciacovelli
Very interesting work about how DLAT suppresses leucine catabolism via acetylation of AUH, ultimately favouring activation of mTOR and hepatic cancer
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
Pyruvate and branched-chain amino acid (BCAA) metabolism are pivotal pathways in tumor progression, yet the intricate interplay between them and its i…
www.sciencedirect.com
June 4, 2025 at 12:09 PM
Very interesting work about how DLAT suppresses leucine catabolism via acetylation of AUH, ultimately favouring activation of mTOR and hepatic cancer
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Marco Sciacovelli
Interested in the interplay between histone supply, epigenetics and cancer biology? This research intensive Masters (MRes) course at the University of Liverpool could be for you! Apply by 29th August 2025. www.liverpool.ac.uk/courses/biol...
June 3, 2025 at 8:52 AM
Interested in the interplay between histone supply, epigenetics and cancer biology? This research intensive Masters (MRes) course at the University of Liverpool could be for you! Apply by 29th August 2025. www.liverpool.ac.uk/courses/biol...
Reposted by Marco Sciacovelli
Cross-organ metabolite production and consumption in healthy and atherogenic conditions: Cell www.cell.com/cell/fulltex...
Cross-organ metabolite production and consumption in healthy and atherogenic conditions
An atlas mapping organ-specific metabolite production and consumption across various
pathophysiological states in pigs shows impaired metabolic activity across organs
by a Western diet or hypercholest...
www.cell.com
May 29, 2025 at 2:20 PM
Cross-organ metabolite production and consumption in healthy and atherogenic conditions: Cell www.cell.com/cell/fulltex...
Reposted by Marco Sciacovelli
Ever wondered which method to use to infer kinase activities from phosphoproteomics data? 💻💭Our revised comprehensive evaluation of kinase activity inference tools, done in collaboration with the Zhang lab @bcmhouston.bsky.social, is now out @natcomms.nature.com 🔬 tinyurl.com/4twuc6z4
May 23, 2025 at 7:38 AM
Ever wondered which method to use to infer kinase activities from phosphoproteomics data? 💻💭Our revised comprehensive evaluation of kinase activity inference tools, done in collaboration with the Zhang lab @bcmhouston.bsky.social, is now out @natcomms.nature.com 🔬 tinyurl.com/4twuc6z4
Reposted by Marco Sciacovelli
Good Sunday all. Science keeps on delivering beautiful discoveries despite all. Check the curated summary of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
The time you enjoy wasting is not wasted time.
Bertrand Russell
The time you enjoy wasting is not wasted time.
Bertrand Russell
a man holding a book titled zero and the art of managing the law exam
ALT: a man holding a book titled zero and the art of managing the law exam
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May 18, 2025 at 5:30 AM
Good Sunday all. Science keeps on delivering beautiful discoveries despite all. Check the curated summary of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
The time you enjoy wasting is not wasted time.
Bertrand Russell
The time you enjoy wasting is not wasted time.
Bertrand Russell
Reposted by Marco Sciacovelli
Good morning all! Another week has passed, multiple groundbreaking discoveries were made. Don't miss them, find them here: biomed.news/bims-camemi/...
@Bims_BiomedNews #readingtime
And what importance do I have in the courtroom of oblivion?
Pablo Neruda
@Bims_BiomedNews #readingtime
And what importance do I have in the courtroom of oblivion?
Pablo Neruda
a man is sitting in a chair reading a sunday newspaper
ALT: a man is sitting in a chair reading a sunday newspaper
media.tenor.com
May 11, 2025 at 5:40 AM
Good morning all! Another week has passed, multiple groundbreaking discoveries were made. Don't miss them, find them here: biomed.news/bims-camemi/...
@Bims_BiomedNews #readingtime
And what importance do I have in the courtroom of oblivion?
Pablo Neruda
@Bims_BiomedNews #readingtime
And what importance do I have in the courtroom of oblivion?
Pablo Neruda
Very nice review about the role of TCA cycle-linked metabolites in regulating the functionality of macrophages
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation
The Krebs cycle intermediates itaconate, succinate, and fumarate act as immunometabolites
to regulate macrophage immune responses. This review highlights how these metabolites
influence cytokine produ...
www.cell.com
May 12, 2025 at 9:36 AM
Very nice review about the role of TCA cycle-linked metabolites in regulating the functionality of macrophages
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Reposted by Marco Sciacovelli
Pint of Science featuring some of staff members:
"Keeping a Close Eye on Cancer"
Keep a look out for tickets (currently sold out!!)
@paulatherton.bsky.social
pintofscience.co.uk/event/keepin...
"Keeping a Close Eye on Cancer"
Keep a look out for tickets (currently sold out!!)
@paulatherton.bsky.social
pintofscience.co.uk/event/keepin...
Keeping a Close Eye on Cancer
To understand most stories you should start from the beginning. We’ll explore how some cancers form, whether the gut microbiome could revolutionise the way…
pintofscience.co.uk
May 6, 2025 at 11:30 AM
Pint of Science featuring some of staff members:
"Keeping a Close Eye on Cancer"
Keep a look out for tickets (currently sold out!!)
@paulatherton.bsky.social
pintofscience.co.uk/event/keepin...
"Keeping a Close Eye on Cancer"
Keep a look out for tickets (currently sold out!!)
@paulatherton.bsky.social
pintofscience.co.uk/event/keepin...
Reposted by Marco Sciacovelli
We have an exciting 2 year postdoc position available in our department in the lab of Marisa Merino - please see advert attached!
Please contact Marisa for more details!
Repost and share as you wish!
Please contact Marisa for more details!
Repost and share as you wish!
May 2, 2025 at 9:49 AM
We have an exciting 2 year postdoc position available in our department in the lab of Marisa Merino - please see advert attached!
Please contact Marisa for more details!
Repost and share as you wish!
Please contact Marisa for more details!
Repost and share as you wish!
Very cool work about the role of the branched-chain amino acids in regulating transcription in pancreatic cancer via histone propionylation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer
Branched-chain amino acid (BCAA) catabolism contributes prominently to the TCA cycle in the healthy pancreas but is suppressed in pancreatic ductal adenocarcinoma (PDA). The impact of this metabolic r...
www.biorxiv.org
April 30, 2025 at 2:28 PM
Very cool work about the role of the branched-chain amino acids in regulating transcription in pancreatic cancer via histone propionylation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Marco Sciacovelli
A belated weekly issue of papers in #cancermetabolism and #mitochondriabiology is ready for you! Check it out here: biomed.news/bims-camemi/... @biomednews.bsky.social
"You have to do nothing to be who you are. Nothing at all."
-H. W. L. Poonja
"You have to do nothing to be who you are. Nothing at all."
-H. W. L. Poonja
an illustration of a bird holding a stack of books with reading time written above it
ALT: an illustration of a bird holding a stack of books with reading time written above it
media.tenor.com
April 27, 2025 at 11:41 AM
A belated weekly issue of papers in #cancermetabolism and #mitochondriabiology is ready for you! Check it out here: biomed.news/bims-camemi/... @biomednews.bsky.social
"You have to do nothing to be who you are. Nothing at all."
-H. W. L. Poonja
"You have to do nothing to be who you are. Nothing at all."
-H. W. L. Poonja
Reposted by Marco Sciacovelli
Good Sunday, all! Another week, another set of massive discoveries in #cancermatabolism and #mitochondrialbiology! Find them here:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
Be kind, for everyone is fighting a hard battle.
John Watson
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
Be kind, for everyone is fighting a hard battle.
John Watson
a painting of a woman sitting on a porch with a dog and the words blingee at the bottom
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media.tenor.com
April 13, 2025 at 5:45 AM
Good Sunday, all! Another week, another set of massive discoveries in #cancermatabolism and #mitochondrialbiology! Find them here:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
Be kind, for everyone is fighting a hard battle.
John Watson
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
Be kind, for everyone is fighting a hard battle.
John Watson