Michael O’Dea
@mrodea.bsky.social
neuroscience phd student in the Liddelow lab at NYU GSoM | 🏳️🌈
Reposted by Michael O’Dea
📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠
tinyurl.com/3wvmm8v3
tinyurl.com/3wvmm8v3
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …
tinyurl.com
November 12, 2025 at 10:41 PM
📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠
tinyurl.com/3wvmm8v3
tinyurl.com/3wvmm8v3
Reposted by Michael O’Dea
Looking forward to presenting our work on oligodendrocyte dysfunction in a rare neurodegenerative movement disorder X-linked Dystonia Parkinsonism. Come say hi if you're around on Tuesday, Nov 18 between 1-5 pm! @sfn.org #SfN2025 #SfN25
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 10, 2025 at 11:09 PM
Reposted by Michael O’Dea
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 10, 2025 at 4:43 PM
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Reposted by Michael O’Dea
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
October 24, 2025 at 4:32 PM
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Reposted by Michael O’Dea
Astrocytes are connected by gap junctions in large, plastic networks that link brain regions not connected by neurons, a new preprint shows.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
Astrocyte networks span large swaths of brain
The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.
www.thetransmitter.org
September 3, 2025 at 1:57 PM
Astrocytes are connected by gap junctions in large, plastic networks that link brain regions not connected by neurons, a new preprint shows.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
Reposted by Michael O’Dea
A big thank you to The Transmitter and @callimcflurry.bsky.social for the spotlight on our preprint!
You can check out her article below, or the preprint here: doi.org/10.1101/2025...
You can check out her article below, or the preprint here: doi.org/10.1101/2025...
Astrocytes are connected by gap junctions in large, plastic networks that link brain regions not connected by neurons, a new preprint shows.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
Astrocyte networks span large swaths of brain
The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.
www.thetransmitter.org
September 3, 2025 at 4:05 PM
A big thank you to The Transmitter and @callimcflurry.bsky.social for the spotlight on our preprint!
You can check out her article below, or the preprint here: doi.org/10.1101/2025...
You can check out her article below, or the preprint here: doi.org/10.1101/2025...
Reposted by Michael O’Dea
Now on bioRxiv! Astrocytes in one brain region (cyan) communicate in expansive networks (magenta). Through tool development, tissue clearing, and many hours on our @zeiss-microscopy.bsky.social Z1, we now know these networks are repeatable across mice, plastic, and specific.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
July 22, 2025 at 8:54 PM
Now on bioRxiv! Astrocytes in one brain region (cyan) communicate in expansive networks (magenta). Through tool development, tissue clearing, and many hours on our @zeiss-microscopy.bsky.social Z1, we now know these networks are repeatable across mice, plastic, and specific.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Michael O’Dea
Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1
July 22, 2025 at 7:15 PM
Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1
Reposted by Michael O’Dea
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains
is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets
and lose their phagocytic cap...
www.cell.com
May 19, 2025 at 6:14 PM
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Reposted by Michael O’Dea
Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com
gleichmanlab.com
The Gleichman lab
gleichmanlab.com
May 1, 2025 at 8:24 PM
Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com
gleichmanlab.com
Reposted by Michael O’Dea
Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.
Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.
dlvr.it
April 30, 2025 at 9:20 PM
Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.
Reposted by Michael O’Dea
Amped to share this masterclass of a paper spearheaded by @waisenberg.bsky.social, out today in Immunity. Will et al. provide a deeply detailed look into microglia dysfunction in Krabbe disease & show that microglia replacement therapeutically improves disease outcomes!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell
leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular
signature of disease-associated ...
www.cell.com
April 30, 2025 at 4:32 PM
Amped to share this masterclass of a paper spearheaded by @waisenberg.bsky.social, out today in Immunity. Will et al. provide a deeply detailed look into microglia dysfunction in Krabbe disease & show that microglia replacement therapeutically improves disease outcomes!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
New preprint evaluating the recent claim of epigenetically regulated immune memory in astrocytes.
We believe this finding was likely artifactual, resulting from immune cell contamination & cell type mis-annotation across multiple transcriptomics experiments:
We believe this finding was likely artifactual, resulting from immune cell contamination & cell type mis-annotation across multiple transcriptomics experiments:
Epigenetic memory astrocytes are likely an artifact of immune cell contamination https://www.biorxiv.org/content/10.1101/2025.04.04.647246v1
April 8, 2025 at 4:26 PM
New preprint evaluating the recent claim of epigenetically regulated immune memory in astrocytes.
We believe this finding was likely artifactual, resulting from immune cell contamination & cell type mis-annotation across multiple transcriptomics experiments:
We believe this finding was likely artifactual, resulting from immune cell contamination & cell type mis-annotation across multiple transcriptomics experiments:
Reposted by Michael O’Dea
Fresh off the press! We found that degeneration in one retina causes astrocytes to respond retinotopically across *both* hemispheres of the brain. Perhaps astrocytes across the CNS are able to coordinate their responses more than we anticipated... www.pnas.org/doi/10.1073/...
March 10, 2025 at 9:13 PM
Fresh off the press! We found that degeneration in one retina causes astrocytes to respond retinotopically across *both* hemispheres of the brain. Perhaps astrocytes across the CNS are able to coordinate their responses more than we anticipated... www.pnas.org/doi/10.1073/...
Reposted by Michael O’Dea
At @standupforscience.bsky.social and the signs are statistically significantly excellent
March 7, 2025 at 6:51 PM
At @standupforscience.bsky.social and the signs are statistically significantly excellent
Reposted by Michael O’Dea
Our paper on the superficial glia limitans is now published - huge thank you to all co-authors that helped getting this work across the finish line! www.cell.com/cell-reports...
Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates
Hasel et al. show that molecularly and morphologically specialized astrocytes make
up the brain and spinal cord surface, thereby creating the glia limitans superficialis.
These astrocytes selectively ...
www.cell.com
February 24, 2025 at 10:44 AM
Our paper on the superficial glia limitans is now published - huge thank you to all co-authors that helped getting this work across the finish line! www.cell.com/cell-reports...
Reposted by Michael O’Dea
If you can, do something, speak up and act up. www.science.org/doi/10.1126/...
Scientists as political advocates
Science, both teaching and doing, is under attack. The recent US presidential election of a person and platform with anti-science bias exemplifies this. The study of climate processes and patterns and...
www.science.org
February 2, 2025 at 12:56 PM
If you can, do something, speak up and act up. www.science.org/doi/10.1126/...
Reposted by Michael O’Dea
#GliaPapers #GliaSpecial2025 REVIEW
@mrodea.bsky.social, @philiphasel.bsky.social
Are we there yet? Exploring astrocyte heterogeneity one cell at a time
onlinelibrary.wiley.com/doi/10.1002/...
@mrodea.bsky.social, @philiphasel.bsky.social
Are we there yet? Exploring astrocyte heterogeneity one cell at a time
onlinelibrary.wiley.com/doi/10.1002/...
January 31, 2025 at 5:35 PM
#GliaPapers #GliaSpecial2025 REVIEW
@mrodea.bsky.social, @philiphasel.bsky.social
Are we there yet? Exploring astrocyte heterogeneity one cell at a time
onlinelibrary.wiley.com/doi/10.1002/...
@mrodea.bsky.social, @philiphasel.bsky.social
Are we there yet? Exploring astrocyte heterogeneity one cell at a time
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Michael O’Dea
#GliaPapers #GliaSpecialIssue
SPECIAL COVER
SPECIAL ISSUE: Glial omics: unraveling mechanisms in health and disease
onlinelibrary.wiley.com/toc/10981136...
Editorial Unboxing “Omics” in Glial Biology to Understand Neurological Disease here - onlinelibrary.wiley.com/doi/10.1002/...
SPECIAL COVER
SPECIAL ISSUE: Glial omics: unraveling mechanisms in health and disease
onlinelibrary.wiley.com/toc/10981136...
Editorial Unboxing “Omics” in Glial Biology to Understand Neurological Disease here - onlinelibrary.wiley.com/doi/10.1002/...
Special Issue: Glial omics: Unraveling mechanisms in health and disease: Glia: Vol 73, No 3
Glia is the top neurobiology journal for research into glial cells (also called gliocytes or neuroglia). Articles cover all aspects of glial cell biology in health and disease.
onlinelibrary.wiley.com
January 31, 2025 at 5:35 PM
#GliaPapers #GliaSpecialIssue
SPECIAL COVER
SPECIAL ISSUE: Glial omics: unraveling mechanisms in health and disease
onlinelibrary.wiley.com/toc/10981136...
Editorial Unboxing “Omics” in Glial Biology to Understand Neurological Disease here - onlinelibrary.wiley.com/doi/10.1002/...
SPECIAL COVER
SPECIAL ISSUE: Glial omics: unraveling mechanisms in health and disease
onlinelibrary.wiley.com/toc/10981136...
Editorial Unboxing “Omics” in Glial Biology to Understand Neurological Disease here - onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Michael O’Dea
Scientific advancements aside, this is economically irresponsible
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
January 22, 2025 at 11:04 PM
Scientific advancements aside, this is economically irresponsible
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Reposted by Michael O’Dea
We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 15, 2025 at 8:32 PM
We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Michael O’Dea
First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A 🧵
Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma
Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...
rdcu.be
January 8, 2025 at 5:13 PM
First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A 🧵
Reposted by Michael O’Dea
3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience.
A MUST READ if you're doing transcriptomics.
3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year!
(mini thread)
A MUST READ if you're doing transcriptomics.
3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year!
(mini thread)
December 11, 2024 at 5:04 PM
3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience.
A MUST READ if you're doing transcriptomics.
3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year!
(mini thread)
A MUST READ if you're doing transcriptomics.
3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year!
(mini thread)
Reposted by Michael O’Dea
Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n
December 3, 2024 at 5:22 PM
Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n
Reposted by Michael O’Dea
PhD opportunity: If you're interested in how astrocytes and the meninges talk to each other and how this is affected in dementia come do your PhD with us in Edinburgh (cc: Karen Horsburgh and Ingo Schiessl)!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
(VIDA DTC) Exploring the role of the astrocyte-leptomeningeal vessel interface in dementia at University of Edinburgh on FindAPhD.com
PhD Project - (VIDA DTC) Exploring the role of the astrocyte-leptomeningeal vessel interface in dementia at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
November 25, 2024 at 10:21 AM
PhD opportunity: If you're interested in how astrocytes and the meninges talk to each other and how this is affected in dementia come do your PhD with us in Edinburgh (cc: Karen Horsburgh and Ingo Schiessl)!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...