Moritz Treeck
@moritztreeck.bsky.social
Cell Biology of Host-Pathogen interaction @work (www.gimm.pt) in Oeiras/Lisbon ; enjoying sun and sea in Portugal when not @work
www.treecklab.org
https://gimm.pt/lab/moritz-treeck-lab/
www.treecklab.org
https://gimm.pt/lab/moritz-treeck-lab/
Pinned
Moritz Treeck
@moritztreeck.bsky.social
· Jun 23
www.biorxiv.org
What happens when the parasite that causes malaria in humans experiences fever-induced heat stress in its host red blood cell?
Check out David Jones' PhD work now on BioRxiv
www.biorxiv.org/content/10.1...
Check out David Jones' PhD work now on BioRxiv
www.biorxiv.org/content/10.1...
David Jones PhD manuscript on how mild heat stress (experienced during fever episodes in most malaria infections)changes the cytoadhesion behavior of parasite infected red blood cells is now online and reviewed in eLife.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell
elifesciences.org
August 30, 2025 at 7:50 AM
David Jones PhD manuscript on how mild heat stress (experienced during fever episodes in most malaria infections)changes the cytoadhesion behavior of parasite infected red blood cells is now online and reviewed in eLife.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by Moritz Treeck
Better late than never, but I am thrilled to share our newest research from the Treeck lab!!! www.nature.com/articles/s41...
The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound - Nature Microbiology
FIKK effector kinases underwent rapid evolutionary expansion and are a druggable target in Plasmodium falciparum.
www.nature.com
June 23, 2025 at 1:28 PM
Better late than never, but I am thrilled to share our newest research from the Treeck lab!!! www.nature.com/articles/s41...
What happens when the parasite that causes malaria in humans experiences fever-induced heat stress in its host red blood cell?
Check out David Jones' PhD work now on BioRxiv
www.biorxiv.org/content/10.1...
Check out David Jones' PhD work now on BioRxiv
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 23, 2025 at 8:58 AM
What happens when the parasite that causes malaria in humans experiences fever-induced heat stress in its host red blood cell?
Check out David Jones' PhD work now on BioRxiv
www.biorxiv.org/content/10.1...
Check out David Jones' PhD work now on BioRxiv
www.biorxiv.org/content/10.1...
Reposted by Moritz Treeck
Excellent and thought-provoking. A highly recommended read
After the latest round of grading papers, I wrote about AI, ChatGPT, the death of the student essay, and what it means for the future of human cognition.
The Death of the Student Essay—and the Future of Cognition
One professor's reflections on the end of an era, as AI tools such as ChatGPT have murdered the student essay (RIP). Here's why that threatens the future of human cognition—and how to save ourselves.
www.forkingpaths.co
June 20, 2025 at 8:49 AM
Excellent and thought-provoking. A highly recommended read
Really cool work! Congrats all!
Extremely happy to share the first paper of my postdoc work with @parasitematt.
It is the product of a great collaboration with Akihito Sakoguchi, Hisashi Arase and Shiroh Iwanaga at Osaka University as well as Marcus Widdess and Mike Dustin here in Oxford.
rdcu.be/eqx2J
🧵 1/6
It is the product of a great collaboration with Akihito Sakoguchi, Hisashi Arase and Shiroh Iwanaga at Osaka University as well as Marcus Widdess and Mike Dustin here in Oxford.
rdcu.be/eqx2J
🧵 1/6
June 16, 2025 at 11:12 AM
Really cool work! Congrats all!
This is SO important!
Make open access to tools and data part of your annual giving by making a tax deductible donation to @veupathdb.org. 💙This resource simplifies and supercharges global infectious disease research.
Need more reasons to support VEuPathDB? Here's a short list: veupathdb.org/veupathdb/ap...
Need more reasons to support VEuPathDB? Here's a short list: veupathdb.org/veupathdb/ap...
June 2, 2025 at 7:33 PM
This is SO important!
Huge congratulations to @hbelda.bsky.social and David Bradley for their publication on the extraordinarily interesting FIKK kinase family (I am biased) of the malaria causing parasite Plasmodium falciparum. 1/n
May 19, 2025 at 9:20 PM
Huge congratulations to @hbelda.bsky.social and David Bradley for their publication on the extraordinarily interesting FIKK kinase family (I am biased) of the malaria causing parasite Plasmodium falciparum. 1/n
A common virulence factor that protects Toxoplasma (and probably related parasites) from clearance in genetically diverse murine hosts. A heroic CRISPR screening effort from @fratorelli.bsky.social with some help from colleagues. Thanks to anonymous reviewers for some good suggestions.
1/2
1/2
🎉 Finally online 🎉 GRA12, the first identified common virulence factor across Toxoplasma strains and murine subspecies! Check this improved manuscript after reviewers’ helpful suggestions www.nature.com/articles/s41...
GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspecies - Nature Communications
CRISPR screens reveal Toxoplasma’s GRA12 as a strain- and mouse species-transcendent virulence factor. GRA12 protects parasites from IFNγ-activated macrophage clearance and parasitophorous vacuole col...
www.nature.com
April 17, 2025 at 6:00 PM
A common virulence factor that protects Toxoplasma (and probably related parasites) from clearance in genetically diverse murine hosts. A heroic CRISPR screening effort from @fratorelli.bsky.social with some help from colleagues. Thanks to anonymous reviewers for some good suggestions.
1/2
1/2
Open call for 3 Group Leader Positions at the newly formed GIMM in Lisbon! Strong core facilites, Science across many disciplines + Sunshine, Beaches and the Atlantic.
Link to call here
gimm.pt/jobs/open-ca...
Link to call here
gimm.pt/jobs/open-ca...
April 10, 2025 at 1:18 PM
Open call for 3 Group Leader Positions at the newly formed GIMM in Lisbon! Strong core facilites, Science across many disciplines + Sunshine, Beaches and the Atlantic.
Link to call here
gimm.pt/jobs/open-ca...
Link to call here
gimm.pt/jobs/open-ca...
Reposted by Moritz Treeck
Symbnet PhD Summer School on Host-Microbe Symbioses - Oeiras Portugal. Students from all over the world are eligible, we sponsor selected students. Please Repost!
gimm.idloom.events/phd-summer-s...
gimm.idloom.events/phd-summer-s...
PhD Summer School on Host-Microbe Symbioses 2025
Symbnet PhD Summer School on Host-Microbe Symbioses Gulbenkian Institute for Molecular Medicine (GIMM) & Católica Biomedical Research Centre (CBR) July 06...
gimm.idloom.events
March 16, 2025 at 12:26 PM
Symbnet PhD Summer School on Host-Microbe Symbioses - Oeiras Portugal. Students from all over the world are eligible, we sponsor selected students. Please Repost!
gimm.idloom.events/phd-summer-s...
gimm.idloom.events/phd-summer-s...
Reposted by Moritz Treeck
I am beyond excited to share that you can now apply to observe a @wellcometrust.bsky.social #DiscoveryResearch shortlisting Committee! If you plan to apply to us in the next 2 years, apply to be an Observer now to better understand what happens once you click submit! wellcome.org/grant-fundin...
Apply to observe a Wellcome funding advisory committee | Prepare to Apply | Wellcome
Find out how to observe a Wellcome funding advisory committee. Researchers who are considering applying for Wellcome funding in the next two years can apply to observe a shortlisting committee.
wellcome.org
February 21, 2025 at 12:00 PM
I am beyond excited to share that you can now apply to observe a @wellcometrust.bsky.social #DiscoveryResearch shortlisting Committee! If you plan to apply to us in the next 2 years, apply to be an Observer now to better understand what happens once you click submit! wellcome.org/grant-fundin...
Reposted by Moritz Treeck
Host-Microbe Symbioses- Our favorite summer school is back! Help us spread the word!
Save the date 📅: The PhD Summer School on Host-microbe Symbioses is taking place from 6-19 of July in Oeiras, Portugal.
Registration is opening soon!
Learn more 👉 gimm.idloom.events/phd-summer-s...
@gimmfoundation.bsky.social @moorefound.bsky.social
@crc1182.bsky.social #CIFAR #CBR
Registration is opening soon!
Learn more 👉 gimm.idloom.events/phd-summer-s...
@gimmfoundation.bsky.social @moorefound.bsky.social
@crc1182.bsky.social #CIFAR #CBR
February 11, 2025 at 8:44 AM
Host-Microbe Symbioses- Our favorite summer school is back! Help us spread the word!
Very happy for bluesky-less David Anaguano from the lab for being offered a Marie-Sklodowska-Curie fellowship! Well done!
February 10, 2025 at 10:51 AM
Very happy for bluesky-less David Anaguano from the lab for being offered a Marie-Sklodowska-Curie fellowship! Well done!
Reposted by Moritz Treeck
🎺 PhD studentship available at @lshtm.bsky.social and RVC! @influenzal.bsky.social and I are advertising for a project to investigate the unexpected phenomenon that mutagenic antiviral drugs can give rise to viruses with hundreds of mutations which are still viable. 🧵
www.lshtm.ac.uk/study/fees-a...
www.lshtm.ac.uk/study/fees-a...
2025-26 Bloomsbury Colleges PhD Studentships | LSHTM
The Bloomsbury Colleges group was set up in 2004 and consists of five institutions: Birkbeck, London School of Hygiene & Tropical Medicine (LSHTM), the Royal Veterinary College (RVC), the School of Or...
www.lshtm.ac.uk
January 22, 2025 at 12:04 PM
🎺 PhD studentship available at @lshtm.bsky.social and RVC! @influenzal.bsky.social and I are advertising for a project to investigate the unexpected phenomenon that mutagenic antiviral drugs can give rise to viruses with hundreds of mutations which are still viable. 🧵
www.lshtm.ac.uk/study/fees-a...
www.lshtm.ac.uk/study/fees-a...
Reposted by Moritz Treeck
Have you finished your #PhD and are interested in exploring how #parasites cross the vasculature to colonize tissues? Do you fancy catching some #waves in the Atlantic? Or eating grilled fish by the beach?
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
January 13, 2025 at 8:28 PM
Have you finished your #PhD and are interested in exploring how #parasites cross the vasculature to colonize tissues? Do you fancy catching some #waves in the Atlantic? Or eating grilled fish by the beach?
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
Reposted by Moritz Treeck
🦟🌍 Join us for the 21st edition of #EMBLMalaria as we strengthen partnerships, share insights, and drive innovations to combat malaria's toll and advance global health.
📅 20 – 22 May 2025
📍 EMBL Heidelberg and Virtual
📝 Submit abstract by 25 Feb
👉🏻 s.embl.org/bmp25-01-bl
#malaria #epidemiology
📅 20 – 22 May 2025
📍 EMBL Heidelberg and Virtual
📝 Submit abstract by 25 Feb
👉🏻 s.embl.org/bmp25-01-bl
#malaria #epidemiology
December 16, 2024 at 1:14 PM
🦟🌍 Join us for the 21st edition of #EMBLMalaria as we strengthen partnerships, share insights, and drive innovations to combat malaria's toll and advance global health.
📅 20 – 22 May 2025
📍 EMBL Heidelberg and Virtual
📝 Submit abstract by 25 Feb
👉🏻 s.embl.org/bmp25-01-bl
#malaria #epidemiology
📅 20 – 22 May 2025
📍 EMBL Heidelberg and Virtual
📝 Submit abstract by 25 Feb
👉🏻 s.embl.org/bmp25-01-bl
#malaria #epidemiology
Credit goes to the fabolous current and past lab members @fratorelli.bsky.social, Diogo da Fonseca, @simon-butterworth.bsky.social and @youngtoxolab.bsky.social
The hypothesis for this work was formed when we expectedly observed some Toxoplasma mutants with known fitness defects not showing defects in in vivo CRISPR screens. The results indicate that CRISPR screens can miss important virulence factors through paracine effects that function in the host.
In Toxoplasma gondii, a parasite infamous for manipulating the behaviour of its hosts that infects an estimated ⅓ of humans, genetic defects are rescued if co-infected with normal parasites, thanks to supportive secreted proteins.
https://buff.ly/3BtpD86
https://buff.ly/3BtpD86
December 16, 2024 at 11:51 AM
Credit goes to the fabolous current and past lab members @fratorelli.bsky.social, Diogo da Fonseca, @simon-butterworth.bsky.social and @youngtoxolab.bsky.social
The hypothesis for this work was formed when we expectedly observed some Toxoplasma mutants with known fitness defects not showing defects in in vivo CRISPR screens. The results indicate that CRISPR screens can miss important virulence factors through paracine effects that function in the host.
In Toxoplasma gondii, a parasite infamous for manipulating the behaviour of its hosts that infects an estimated ⅓ of humans, genetic defects are rescued if co-infected with normal parasites, thanks to supportive secreted proteins.
https://buff.ly/3BtpD86
https://buff.ly/3BtpD86
December 16, 2024 at 10:47 AM
The hypothesis for this work was formed when we expectedly observed some Toxoplasma mutants with known fitness defects not showing defects in in vivo CRISPR screens. The results indicate that CRISPR screens can miss important virulence factors through paracine effects that function in the host.
Congrats to Catarina Rosa in the lab for securing an EMBO fellowship! Perfect timing for the xmas party with my amazing, creative team! We are looking forward to a new year full of exciting host-pathogen biology discoveries (whilst enjoying life)!
December 14, 2024 at 5:02 PM
Congrats to Catarina Rosa in the lab for securing an EMBO fellowship! Perfect timing for the xmas party with my amazing, creative team! We are looking forward to a new year full of exciting host-pathogen biology discoveries (whilst enjoying life)!
See you next year, and don't forget your mug folks!
Twice means it’s a tradition! Glühwein before Christmas organized by great @moritztreeck.bsky.social and with participation of @nordenlab.bsky.social. We Germans need to get the Portuguese into the spirit. It was even almost cold enough 😉
December 14, 2024 at 5:01 PM
See you next year, and don't forget your mug folks!
Congrats Bishara and team @saterialelab.bsky.social to this wonderful piece of work!
Essential read for all those that have not heard about it yet and are interested in host-pathogen interaction.
Essential read for all those that have not heard about it yet and are interested in host-pathogen interaction.
Have you ever wondered how knocking out every single gene in the human genome, one by one, might affect your intracellular pathogen of interest? We did, & boy was it a wild ride! Happy to share our preprint discovering the essential host genome for Cryptosporidium -
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 6, 2024 at 2:45 PM
Congrats Bishara and team @saterialelab.bsky.social to this wonderful piece of work!
Essential read for all those that have not heard about it yet and are interested in host-pathogen interaction.
Essential read for all those that have not heard about it yet and are interested in host-pathogen interaction.
Reposted by Moritz Treeck
Are you looking for fungi funding? 🍄
We’re offering up to £3 million per award to research how fungi adapt to their environment.
Understanding this could have powerful benefits for human life and health.
Apply by 28 January ⤵️
wellcome.org/grant-fundin...
We’re offering up to £3 million per award to research how fungi adapt to their environment.
Understanding this could have powerful benefits for human life and health.
Apply by 28 January ⤵️
wellcome.org/grant-fundin...
Fungal adaptation | Grant Funding | Wellcome
This award will fund research on the mechanisms and triggers for fungal adaptation. Find out eligibility, what's in scope and how to apply.
wellcome.org
December 6, 2024 at 11:45 AM
Are you looking for fungi funding? 🍄
We’re offering up to £3 million per award to research how fungi adapt to their environment.
Understanding this could have powerful benefits for human life and health.
Apply by 28 January ⤵️
wellcome.org/grant-fundin...
We’re offering up to £3 million per award to research how fungi adapt to their environment.
Understanding this could have powerful benefits for human life and health.
Apply by 28 January ⤵️
wellcome.org/grant-fundin...
Join us!
I'm looking for a research technician! If you're interested in studying how malaria gametocytes remodel their host cell come join us on a @wellcometrust.bsky.social funded project at GIMM by applying here: gimm.pt/jobs/laborat...
Deadline 20th December. Please share!
Deadline 20th December. Please share!
Laboratory Technician – GIMMLaboratory Technician – GIMM
GIMM is recruiting a Laboratory Technician under an Employment Contract – Reference GIMM/CT/35-2024
gimm.pt
December 3, 2024 at 1:33 PM
Join us!
Reposted by Moritz Treeck
Cryptosporidium is an important public health threat, and it deserves better genetic tools to study it! Here we’ve developed a targeted in vivo CRISPR genetic screen to identify parasite genes required for survival and virulence…
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 23, 2024 at 1:29 PM
Cryptosporidium is an important public health threat, and it deserves better genetic tools to study it! Here we’ve developed a targeted in vivo CRISPR genetic screen to identify parasite genes required for survival and virulence…
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...