Mohamed Kehili
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Mohamed Kehili
@mohamedke.bsky.social
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Master student in Genetics - Paris
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Reposted by Mohamed Kehili
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The Energy Resistance Principle (ERP) is a quantitative framework that bridges physics and biology, revealing metabolism as the energetic circuitry through which electrons flow, from food to oxygen, to fuel our lives

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authors.elsevier.com/a/1luVK5WXUl...
November 2, 2025 at 3:20 PM
Reposted by Mohamed Kehili
natmetabolism.nature.com
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology
Nature Metabolism, Published online: 04 November 2025; doi:10.1038/s42255-025-01390-yBarnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory responses.
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November 4, 2025 at 5:09 PM
Reposted by Mohamed Kehili
natmetabolism.nature.com
Mitochondrial ROS sources steer neuroinflammation
Nature Metabolism, Published online: 04 November 2025; doi:10.1038/s42255-025-01391-xBy parsing stimulus-responsive sources of astrocytic reactive oxygen species (ROS), Barnett et al. reveal how mitochondrial complex III-derived signals uniquely shape inflammatory responses and astrocyte–neuron crosstalk, linking mitochondrial redox cues to dementia-related neurodegeneration.
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November 4, 2025 at 5:09 PM