Meredith Frazier, PhD
@mnfrazier5.bsky.social
Structural biologist, biochemist, big baseball nerd. Assistant Professor at College of Charleston. Elon University and Vanderbilt alum (⚓️⬇️). Opinions are my own.
Reposted by Meredith Frazier, PhD
My guy wrote an op-ed and it's really good.
Send it to your advancement officer, your dean, your grandmother, your neighbor.
www.chicagotribune.com/2025/09/02/o...
Send it to your advancement officer, your dean, your grandmother, your neighbor.
www.chicagotribune.com/2025/09/02/o...
September 2, 2025 at 4:00 PM
My guy wrote an op-ed and it's really good.
Send it to your advancement officer, your dean, your grandmother, your neighbor.
www.chicagotribune.com/2025/09/02/o...
Send it to your advancement officer, your dean, your grandmother, your neighbor.
www.chicagotribune.com/2025/09/02/o...
Whirlwind few days at #NCCAT with my students freezing and screening grids—they picked up everything quickly! Everyone at the center was so knowledgeable and friendly. Back to the heat and humidity we go now….
August 27, 2025 at 8:55 PM
Whirlwind few days at #NCCAT with my students freezing and screening grids—they picked up everything quickly! Everyone at the center was so knowledgeable and friendly. Back to the heat and humidity we go now….
Reposted by Meredith Frazier, PhD
“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ
June 4, 2025 at 2:30 PM
“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ
Reposted by Meredith Frazier, PhD
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:18 AM
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
Reposted by Meredith Frazier, PhD
Naturally ornate RNA-only complexes revealed by cryo-EM https://www.biorxiv.org/content/10.1101/2024.12.08.627333v1
December 9, 2024 at 2:48 PM
Naturally ornate RNA-only complexes revealed by cryo-EM https://www.biorxiv.org/content/10.1101/2024.12.08.627333v1
Reposted by Meredith Frazier, PhD
University of New Hampshire is among these rural universities that is shedding majors — and this is especially bad since we are the state’s flagship.
When states gut public higher ed funding it’s especially a “fuck you” to rural folks #giftlink
wapo.st/3ZyU5ap
When states gut public higher ed funding it’s especially a “fuck you” to rural folks #giftlink
wapo.st/3ZyU5ap
Rural students’ options shrink as colleges slash majors
As enrollments fall, rural-serving universities are shedding degree programs ranging from music to chemistry.
wapo.st
November 26, 2024 at 12:50 PM
University of New Hampshire is among these rural universities that is shedding majors — and this is especially bad since we are the state’s flagship.
When states gut public higher ed funding it’s especially a “fuck you” to rural folks #giftlink
wapo.st/3ZyU5ap
When states gut public higher ed funding it’s especially a “fuck you” to rural folks #giftlink
wapo.st/3ZyU5ap
Reposted by Meredith Frazier, PhD
New nonfiction science book releases for November, 2024!
What books did I miss? Which of these books are on your tbr?
I am hoping to read THE SERVICEBERRY this month. I have heard it is a more distilled version of Wall Kimmerer's masterpiece BRAIDING SWEETGRASS.
What books did I miss? Which of these books are on your tbr?
I am hoping to read THE SERVICEBERRY this month. I have heard it is a more distilled version of Wall Kimmerer's masterpiece BRAIDING SWEETGRASS.
November 19, 2024 at 10:53 PM
New nonfiction science book releases for November, 2024!
What books did I miss? Which of these books are on your tbr?
I am hoping to read THE SERVICEBERRY this month. I have heard it is a more distilled version of Wall Kimmerer's masterpiece BRAIDING SWEETGRASS.
What books did I miss? Which of these books are on your tbr?
I am hoping to read THE SERVICEBERRY this month. I have heard it is a more distilled version of Wall Kimmerer's masterpiece BRAIDING SWEETGRASS.
Reposted by Meredith Frazier, PhD
Date Announcement #MECC-2025
2025 - Enzyme Mechanisms Chemistry Conference (MECC)
September 27th, 2025.
Univ. of Wisconsin-Milwaukee.
Please put the date on your calendar for MECC. This is a one-day event and registration is free for all participants.
More details to come in the Spring.
2025 - Enzyme Mechanisms Chemistry Conference (MECC)
September 27th, 2025.
Univ. of Wisconsin-Milwaukee.
Please put the date on your calendar for MECC. This is a one-day event and registration is free for all participants.
More details to come in the Spring.
November 18, 2024 at 8:38 PM
Date Announcement #MECC-2025
2025 - Enzyme Mechanisms Chemistry Conference (MECC)
September 27th, 2025.
Univ. of Wisconsin-Milwaukee.
Please put the date on your calendar for MECC. This is a one-day event and registration is free for all participants.
More details to come in the Spring.
2025 - Enzyme Mechanisms Chemistry Conference (MECC)
September 27th, 2025.
Univ. of Wisconsin-Milwaukee.
Please put the date on your calendar for MECC. This is a one-day event and registration is free for all participants.
More details to come in the Spring.
Reposted by Meredith Frazier, PhD
This white cosmos #flower grown in my garden is overlaid with p-coumaric acid molecules, a major constituent in pollen and an essential component in the diet of #bees. It is found in several types of #plants, fruits, and vegetables.
🧪🥽 #gardening #science #chemistry #education #iteachchem #chemed
🧪🥽 #gardening #science #chemistry #education #iteachchem #chemed
November 13, 2024 at 2:43 AM
This white cosmos #flower grown in my garden is overlaid with p-coumaric acid molecules, a major constituent in pollen and an essential component in the diet of #bees. It is found in several types of #plants, fruits, and vegetables.
🧪🥽 #gardening #science #chemistry #education #iteachchem #chemed
🧪🥽 #gardening #science #chemistry #education #iteachchem #chemed
So make the (lab) friendship bracelets, take the moment and taste it…congrats to our graduates Jaci and Andrew!
May 9, 2024 at 8:39 PM
So make the (lab) friendship bracelets, take the moment and taste it…congrats to our graduates Jaci and Andrew!
Why is it impossible for me to make a normal amount of soup? One thing turns into another and I’ve got 3x the number of ingredients and 5L cooking on the stove.
February 4, 2024 at 10:35 PM
Why is it impossible for me to make a normal amount of soup? One thing turns into another and I’ve got 3x the number of ingredients and 5L cooking on the stove.
Reposted by Meredith Frazier, PhD
"To fully harness the potential of basic science in laying the groundwork for curing diseases, it must receive robust funding...it is equally vital to balance [NIH funding to address healthcare needs] with a commitment to maximizing the chance for basic science discovery" 🧪
Basic science is not just a foundation - Nature Cell Biology
Intellectual freedom for scientists, unconstrained by commercial interests and direct application, fuels unexpected discoveries. Curiosity-driven, basic science has yielded a deeper understanding of h...
www.nature.com
January 17, 2024 at 5:41 PM
"To fully harness the potential of basic science in laying the groundwork for curing diseases, it must receive robust funding...it is equally vital to balance [NIH funding to address healthcare needs] with a commitment to maximizing the chance for basic science discovery" 🧪
Reposted by Meredith Frazier, PhD
Counterfeit and compounded semaglutide? It's a mess out there (link fixed this time):
www.science.org/content/blog...
www.science.org/content/blog...
January 2, 2024 at 8:24 PM
Counterfeit and compounded semaglutide? It's a mess out there (link fixed this time):
www.science.org/content/blog...
www.science.org/content/blog...
Reposted by Meredith Frazier, PhD
Yay, the all-new MRC-LMB 2023 #cryoEM course lectures are now online! Happy learning. 🥳
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
December 7, 2023 at 7:17 PM
Yay, the all-new MRC-LMB 2023 #cryoEM course lectures are now online! Happy learning. 🥳
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
Reposted by Meredith Frazier, PhD
Thanks for the awesome spotlight #RNASociety, written by Jennifer!
www.rnasociety.org/prof--cassan...
www.rnasociety.org/prof--cassan...
Prof. Cassandra Hayne
www.rnasociety.org
November 28, 2023 at 1:19 AM
Thanks for the awesome spotlight #RNASociety, written by Jennifer!
www.rnasociety.org/prof--cassan...
www.rnasociety.org/prof--cassan...
Happy Halloween! #catabolism #sciencepuns
October 31, 2023 at 11:23 PM
Happy Halloween! #catabolism #sciencepuns
Happy Halloween!! #catabolism #sciencepuns
October 31, 2023 at 10:54 PM
Happy Halloween!! #catabolism #sciencepuns
Reposted by Meredith Frazier, PhD
Scientists- please read this.
Recently I had a reviewer question why we even solved the crystal structure if Alphafold could predict it.
This editorial summarizes a lot of what I said in response and needs to be talked about more!
#structuralbiology
journals.iucr.org/d/issues/202...
Recently I had a reviewer question why we even solved the crystal structure if Alphafold could predict it.
This editorial summarizes a lot of what I said in response and needs to be talked about more!
#structuralbiology
journals.iucr.org/d/issues/202...
AlphaFold and the future of structural biology
AlphaFold and the future of structural biology
journals.iucr.org
October 7, 2023 at 11:36 AM
Scientists- please read this.
Recently I had a reviewer question why we even solved the crystal structure if Alphafold could predict it.
This editorial summarizes a lot of what I said in response and needs to be talked about more!
#structuralbiology
journals.iucr.org/d/issues/202...
Recently I had a reviewer question why we even solved the crystal structure if Alphafold could predict it.
This editorial summarizes a lot of what I said in response and needs to be talked about more!
#structuralbiology
journals.iucr.org/d/issues/202...
Reposted by Meredith Frazier, PhD
Unusual repetitive DNA sequence in the E. coli genome --> CRISPR ---> genome editing
Ψ Pseudouridine ---> mRNA immunogenicity and potency ---> mRNA COVID vaccine
#basicresearch
Dear funders, dear governments
please increase the basic research budget !
Ψ Pseudouridine ---> mRNA immunogenicity and potency ---> mRNA COVID vaccine
#basicresearch
Dear funders, dear governments
please increase the basic research budget !
October 2, 2023 at 1:52 PM
Unusual repetitive DNA sequence in the E. coli genome --> CRISPR ---> genome editing
Ψ Pseudouridine ---> mRNA immunogenicity and potency ---> mRNA COVID vaccine
#basicresearch
Dear funders, dear governments
please increase the basic research budget !
Ψ Pseudouridine ---> mRNA immunogenicity and potency ---> mRNA COVID vaccine
#basicresearch
Dear funders, dear governments
please increase the basic research budget !
Reposted by Meredith Frazier, PhD
Congratulations to the winners of the Nobel prize! I hope their stories, particularly KK's, force us to confront the misogyny, bias and assumptions about "impact" and "excellence" that very likely limit the recognition of similar innovations that could improve our world.
October 2, 2023 at 3:00 PM
Congratulations to the winners of the Nobel prize! I hope their stories, particularly KK's, force us to confront the misogyny, bias and assumptions about "impact" and "excellence" that very likely limit the recognition of similar innovations that could improve our world.
New archenemy: 0.6 mL epi tubes. Note to self: make companies send a sample to test for easy open close BEFORE making 200 aliquots #chemsky 👩🏻🔬
September 28, 2023 at 7:57 PM
New archenemy: 0.6 mL epi tubes. Note to self: make companies send a sample to test for easy open close BEFORE making 200 aliquots #chemsky 👩🏻🔬