Maximilian Schaefer
@mmschaefer.bsky.social
PhD student at Merad lab @Mount Sinai | prev MSc at Sallusto lab, Becher lab @ETH Zürich & Apotheker @FU Berlin
Thrilled our Perspective in @nataging.nature.com is out! With Matthew D Park et al., we spotlight how aging reshapes RTMs and skews myelopoiesis–with consequences for healthy aging and cancer @miriammerad.bsky.social www.nature.com/articles/s43...
Restoring resident tissue macrophages to combat aging and cancer - Nature Aging
Park and colleagues propose a conceptual framework in which dysregulation of resident tissue macrophages is both a central contributor to how an aging immune system causes diseases, including cancer, ...
www.nature.com
August 14, 2025 at 11:05 PM
Thrilled our Perspective in @nataging.nature.com is out! With Matthew D Park et al., we spotlight how aging reshapes RTMs and skews myelopoiesis–with consequences for healthy aging and cancer @miriammerad.bsky.social www.nature.com/articles/s43...
New preprint out! 🚀Spearheaded by @chiarafalcomata.bsky.social we could show how pancreatic cancer cells evade the immune system by modulating their TME with the extracellular factors Serpine1 (PAI-1) and Serpinb2 (PAI-2)! #PertrubMap #PDAC
🚨 Our new #preprint is out!
doi.org/10.1101/2025...
We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
doi.org/10.1101/2025...
We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
doi.org
June 20, 2025 at 12:46 AM
New preprint out! 🚀Spearheaded by @chiarafalcomata.bsky.social we could show how pancreatic cancer cells evade the immune system by modulating their TME with the extracellular factors Serpine1 (PAI-1) and Serpinb2 (PAI-2)! #PertrubMap #PDAC
Reposted by Maximilian Schaefer
First lab Bluesky post! Happy to share new papers:
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
Ovarian cancer-derived IL-4 promotes immunotherapy resistance
Cancer-derived paracrine factors create distinct “neighborhoods” in the tumor microenvironment,
promoting clonal selection and tumor heterogeneity. In ovarian cancer, IL-4 originating
from a minority ...
www.cell.com
January 15, 2025 at 5:34 PM
First lab Bluesky post! Happy to share new papers:
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
Reposted by Maximilian Schaefer
Very honored to be inducted at the Belgian Royal Academy of Medicine this weekend alongside incredible colleagues. Thank you again to the Academy for honoring my laboratory. It was also refreshing to spend time with like-minded peers amidst all the chaos,
January 27, 2025 at 7:39 PM
Very honored to be inducted at the Belgian Royal Academy of Medicine this weekend alongside incredible colleagues. Thank you again to the Academy for honoring my laboratory. It was also refreshing to spend time with like-minded peers amidst all the chaos,
Reposted by Maximilian Schaefer
Here is link to Shixin's new paper: www.science.org/doi/epdf/10....
Nutrient-driven histone code determines exhausted CD8+ T cell fates
ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...
www.science.org
December 14, 2024 at 3:53 PM
Here is link to Shixin's new paper: www.science.org/doi/epdf/10....
Reposted by Maximilian Schaefer
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 5:58 PM
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...